Surfactant Replacement Therapy at NICU in Amirkola Children Hospital, Iran Experience for a Decade

BACKGROUND AND OBJECTIVE: Surfactant replacement therapy (SRT) recruited for neonatal pulmonary diseases other than respiratory distress syndrome (RDS). Different outcomes were obtained from SRT in neonatal lung diseases. This study was carried out to determine the clinical profile, underlying disea...

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Autores principales:	M Ahmadpour-Kacho, Y Zahedpasha, M Shirvani, T Jahangir
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2010
Materias:	neonate surfactant lung disease respiratory distress syndrome Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1cb67b5dcf4a4af6982a1658a818f66a
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spelling	oai:doaj.org-article:1cb67b5dcf4a4af6982a1658a818f66a2021-11-10T09:00:36ZSurfactant Replacement Therapy at NICU in Amirkola Children Hospital, Iran Experience for a Decade1561-41072251-7170https://doaj.org/article/1cb67b5dcf4a4af6982a1658a818f66a2010-10-01T00:00:00Zhttp://jbums.org/article-1-3668-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Surfactant replacement therapy (SRT) recruited for neonatal pulmonary diseases other than respiratory distress syndrome (RDS). Different outcomes were obtained from SRT in neonatal lung diseases. This study was carried out to determine the clinical profile, underlying diseases, complications and the outcomes of the neonates who received surfactant replacement therapy at NICU in Amirkola children hospital, a referral hospital in the north of Iran. METHODS: In this cross-sectional study, all neonates who received SRT were included during 2000-2009. The more common type of surfactant used was Survanta, but Curosurf and Newfactan were used because of unavailability of Survanta. Age of the neonate at the time of SRT, underlying pulmonary diseases, duration of mechanical ventilation (MV), any complications such as pneumothorax, nosocomial infection, pulmonary hemorrhage, patent ductus arteriosus (PDA) and also mortality rate were recorded.FINDINGS: Out of 213 SRT cases, the frequency of pulmonary lung diseases were as follows: 178(83.56%) RDS, 18(8.45%) pneumonia, 13(6.10%) MAS (Meconium aspiration syndrome) and 4 (1.87%) CHD (Congenital diaphragmatic hernia). The mean gestational age of neonates was 32.32±3.8 weeks and the mean birth weight was 1970 ±875 gr. The mean age of neonate at the time of SRT was 7.3±2.3 hours after birth. The mean duration of MV was 4.05±3.93 days. The prevalence of complications was pneumothorax (42.48%), secondary sepsis (6.05%), PDA (3.67%) and pulmonary hemorrhage (3.42%). Neonatal death occurred in 85 cases. The mortality rate decreased from 48.87% for the first 8 years of the study to 24.88% for the last two years (p=0.003). CONCLUSION: According to the results of this study, RDS was the most common pulmonary disease which required SRT and the survival rate of the surfactant treated neonates increased.M Ahmadpour-KachoY ZahedpashaM ShirvaniT JahangirBabol University of Medical Sciencesarticleneonatesurfactantlung diseaserespiratory distress syndromeMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 12, Iss 4, Pp 54-60 (2010)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	neonate surfactant lung disease respiratory distress syndrome Medicine R Medicine (General) R5-920
spellingShingle	neonate surfactant lung disease respiratory distress syndrome Medicine R Medicine (General) R5-920 M Ahmadpour-Kacho Y Zahedpasha M Shirvani T Jahangir Surfactant Replacement Therapy at NICU in Amirkola Children Hospital, Iran Experience for a Decade
description	BACKGROUND AND OBJECTIVE: Surfactant replacement therapy (SRT) recruited for neonatal pulmonary diseases other than respiratory distress syndrome (RDS). Different outcomes were obtained from SRT in neonatal lung diseases. This study was carried out to determine the clinical profile, underlying diseases, complications and the outcomes of the neonates who received surfactant replacement therapy at NICU in Amirkola children hospital, a referral hospital in the north of Iran. METHODS: In this cross-sectional study, all neonates who received SRT were included during 2000-2009. The more common type of surfactant used was Survanta, but Curosurf and Newfactan were used because of unavailability of Survanta. Age of the neonate at the time of SRT, underlying pulmonary diseases, duration of mechanical ventilation (MV), any complications such as pneumothorax, nosocomial infection, pulmonary hemorrhage, patent ductus arteriosus (PDA) and also mortality rate were recorded.FINDINGS: Out of 213 SRT cases, the frequency of pulmonary lung diseases were as follows: 178(83.56%) RDS, 18(8.45%) pneumonia, 13(6.10%) MAS (Meconium aspiration syndrome) and 4 (1.87%) CHD (Congenital diaphragmatic hernia). The mean gestational age of neonates was 32.32±3.8 weeks and the mean birth weight was 1970 ±875 gr. The mean age of neonate at the time of SRT was 7.3±2.3 hours after birth. The mean duration of MV was 4.05±3.93 days. The prevalence of complications was pneumothorax (42.48%), secondary sepsis (6.05%), PDA (3.67%) and pulmonary hemorrhage (3.42%). Neonatal death occurred in 85 cases. The mortality rate decreased from 48.87% for the first 8 years of the study to 24.88% for the last two years (p=0.003). CONCLUSION: According to the results of this study, RDS was the most common pulmonary disease which required SRT and the survival rate of the surfactant treated neonates increased.
format	article
author	M Ahmadpour-Kacho Y Zahedpasha M Shirvani T Jahangir
author_facet	M Ahmadpour-Kacho Y Zahedpasha M Shirvani T Jahangir
author_sort	M Ahmadpour-Kacho
title	Surfactant Replacement Therapy at NICU in Amirkola Children Hospital, Iran Experience for a Decade
title_short	Surfactant Replacement Therapy at NICU in Amirkola Children Hospital, Iran Experience for a Decade
title_full	Surfactant Replacement Therapy at NICU in Amirkola Children Hospital, Iran Experience for a Decade
title_fullStr	Surfactant Replacement Therapy at NICU in Amirkola Children Hospital, Iran Experience for a Decade
title_full_unstemmed	Surfactant Replacement Therapy at NICU in Amirkola Children Hospital, Iran Experience for a Decade
title_sort	surfactant replacement therapy at nicu in amirkola children hospital, iran experience for a decade
publisher	Babol University of Medical Sciences
publishDate	2010
url	https://doaj.org/article/1cb67b5dcf4a4af6982a1658a818f66a
work_keys_str_mv	AT mahmadpourkacho surfactantreplacementtherapyatnicuinamirkolachildrenhospitaliranexperienceforadecade AT yzahedpasha surfactantreplacementtherapyatnicuinamirkolachildrenhospitaliranexperienceforadecade AT mshirvani surfactantreplacementtherapyatnicuinamirkolachildrenhospitaliranexperienceforadecade AT tjahangir surfactantreplacementtherapyatnicuinamirkolachildrenhospitaliranexperienceforadecade
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Surfactant Replacement Therapy at NICU in Amirkola Children Hospital, Iran Experience for a Decade

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