Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon

Polyamines produced by intestinal bacteria are thought to have beneficial effects on the host. Here the authors show that these polyamines increase regulatory macrophage abundance and are taken up by colonic epithelial cells to enhance colonic barrier function and immunity in mice.

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Autores principales:	Atsuo Nakamura, Shin Kurihara, Daisuke Takahashi, Wakana Ohashi, Yutaka Nakamura, Shunsuke Kimura, Masayoshi Onuki, Aiko Kume, Yukiko Sasazawa, Yukihiro Furusawa, Yuuki Obata, Shinji Fukuda, Shinji Saiki, Mitsuharu Matsumoto, Koji Hase
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1cb82238883f4fe38505d0a785204d7e
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spelling	oai:doaj.org-article:1cb82238883f4fe38505d0a785204d7e2021-12-02T14:26:56ZSymbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon10.1038/s41467-021-22212-12041-1723https://doaj.org/article/1cb82238883f4fe38505d0a785204d7e2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22212-1https://doaj.org/toc/2041-1723Polyamines produced by intestinal bacteria are thought to have beneficial effects on the host. Here the authors show that these polyamines increase regulatory macrophage abundance and are taken up by colonic epithelial cells to enhance colonic barrier function and immunity in mice.Atsuo NakamuraShin KuriharaDaisuke TakahashiWakana OhashiYutaka NakamuraShunsuke KimuraMasayoshi OnukiAiko KumeYukiko SasazawaYukihiro FurusawaYuuki ObataShinji FukudaShinji SaikiMitsuharu MatsumotoKoji HaseNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Atsuo Nakamura Shin Kurihara Daisuke Takahashi Wakana Ohashi Yutaka Nakamura Shunsuke Kimura Masayoshi Onuki Aiko Kume Yukiko Sasazawa Yukihiro Furusawa Yuuki Obata Shinji Fukuda Shinji Saiki Mitsuharu Matsumoto Koji Hase Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon
description	Polyamines produced by intestinal bacteria are thought to have beneficial effects on the host. Here the authors show that these polyamines increase regulatory macrophage abundance and are taken up by colonic epithelial cells to enhance colonic barrier function and immunity in mice.
format	article
author	Atsuo Nakamura Shin Kurihara Daisuke Takahashi Wakana Ohashi Yutaka Nakamura Shunsuke Kimura Masayoshi Onuki Aiko Kume Yukiko Sasazawa Yukihiro Furusawa Yuuki Obata Shinji Fukuda Shinji Saiki Mitsuharu Matsumoto Koji Hase
author_facet	Atsuo Nakamura Shin Kurihara Daisuke Takahashi Wakana Ohashi Yutaka Nakamura Shunsuke Kimura Masayoshi Onuki Aiko Kume Yukiko Sasazawa Yukihiro Furusawa Yuuki Obata Shinji Fukuda Shinji Saiki Mitsuharu Matsumoto Koji Hase
author_sort	Atsuo Nakamura
title	Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon
title_short	Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon
title_full	Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon
title_fullStr	Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon
title_full_unstemmed	Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon
title_sort	symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1cb82238883f4fe38505d0a785204d7e
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Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon

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