Role of Energy Metabolism in the Progression of Neuroblastoma

Neuroblastoma is a common childhood cancer possessing a significant risk of death. This solid tumor manifests variable clinical behaviors ranging from spontaneous regression to widespread metastatic disease. The lack of promising treatments calls for new research approaches which can enhance the und...

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Autores principales:	Monika Sakowicz-Burkiewicz, Tadeusz Pawełczyk, Marlena Zyśk
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	neuroblastoma glycolysis extracellular vesicles Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/1cbec4635d8c4a50ba8b66b16b06fb15
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spelling	oai:doaj.org-article:1cbec4635d8c4a50ba8b66b16b06fb152021-11-11T16:53:30ZRole of Energy Metabolism in the Progression of Neuroblastoma10.3390/ijms2221114211422-00671661-6596https://doaj.org/article/1cbec4635d8c4a50ba8b66b16b06fb152021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11421https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Neuroblastoma is a common childhood cancer possessing a significant risk of death. This solid tumor manifests variable clinical behaviors ranging from spontaneous regression to widespread metastatic disease. The lack of promising treatments calls for new research approaches which can enhance the understanding of the molecular background of neuroblastoma. The high proliferation of malignant neuroblastoma cells requires efficient energy metabolism. Thus, we focus our attention on energy pathways and their role in neuroblastoma tumorigenesis. Recent studies suggest that neuroblastoma-driven extracellular vesicles stimulate tumorigenesis inside the recipient cells. Furthermore, proteomic studies have demonstrated extracellular vesicles (EVs) to cargo metabolic enzymes needed to build up a fully operative energy metabolism network. The majority of EV-derived enzymes comes from glycolysis, while other metabolic enzymes have a fatty acid β-oxidation and tricarboxylic acid cycle origin. The previously mentioned glycolysis has been shown to play a primary role in neuroblastoma energy metabolism. Therefore, another way to modify the energy metabolism in neuroblastoma is linked with genetic alterations resulting in the decreased activity of some tricarboxylic acid cycle enzymes and enhanced glycolysis. This metabolic shift enables malignant cells to cope with increasing metabolic stress, nutrition breakdown and an upregulated proliferation ratio.Monika Sakowicz-BurkiewiczTadeusz PawełczykMarlena ZyśkMDPI AGarticleneuroblastomaglycolysisextracellular vesiclesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11421, p 11421 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuroblastoma glycolysis extracellular vesicles Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	neuroblastoma glycolysis extracellular vesicles Biology (General) QH301-705.5 Chemistry QD1-999 Monika Sakowicz-Burkiewicz Tadeusz Pawełczyk Marlena Zyśk Role of Energy Metabolism in the Progression of Neuroblastoma
description	Neuroblastoma is a common childhood cancer possessing a significant risk of death. This solid tumor manifests variable clinical behaviors ranging from spontaneous regression to widespread metastatic disease. The lack of promising treatments calls for new research approaches which can enhance the understanding of the molecular background of neuroblastoma. The high proliferation of malignant neuroblastoma cells requires efficient energy metabolism. Thus, we focus our attention on energy pathways and their role in neuroblastoma tumorigenesis. Recent studies suggest that neuroblastoma-driven extracellular vesicles stimulate tumorigenesis inside the recipient cells. Furthermore, proteomic studies have demonstrated extracellular vesicles (EVs) to cargo metabolic enzymes needed to build up a fully operative energy metabolism network. The majority of EV-derived enzymes comes from glycolysis, while other metabolic enzymes have a fatty acid β-oxidation and tricarboxylic acid cycle origin. The previously mentioned glycolysis has been shown to play a primary role in neuroblastoma energy metabolism. Therefore, another way to modify the energy metabolism in neuroblastoma is linked with genetic alterations resulting in the decreased activity of some tricarboxylic acid cycle enzymes and enhanced glycolysis. This metabolic shift enables malignant cells to cope with increasing metabolic stress, nutrition breakdown and an upregulated proliferation ratio.
format	article
author	Monika Sakowicz-Burkiewicz Tadeusz Pawełczyk Marlena Zyśk
author_facet	Monika Sakowicz-Burkiewicz Tadeusz Pawełczyk Marlena Zyśk
author_sort	Monika Sakowicz-Burkiewicz
title	Role of Energy Metabolism in the Progression of Neuroblastoma
title_short	Role of Energy Metabolism in the Progression of Neuroblastoma
title_full	Role of Energy Metabolism in the Progression of Neuroblastoma
title_fullStr	Role of Energy Metabolism in the Progression of Neuroblastoma
title_full_unstemmed	Role of Energy Metabolism in the Progression of Neuroblastoma
title_sort	role of energy metabolism in the progression of neuroblastoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1cbec4635d8c4a50ba8b66b16b06fb15
work_keys_str_mv	AT monikasakowiczburkiewicz roleofenergymetabolismintheprogressionofneuroblastoma AT tadeuszpawełczyk roleofenergymetabolismintheprogressionofneuroblastoma AT marlenazysk roleofenergymetabolismintheprogressionofneuroblastoma
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Role of Energy Metabolism in the Progression of Neuroblastoma

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