Pumping infusions with a syringe may cause contamination of the fluid in the syringe

Abstract Clinicians often perform pumping of infusions with a syringe (PIS) to quickly deliver fluid or blood transfusion to patients, especially during an emergency. Despite the efforts of the clinicians, critically ill patients are prone to acquire catheter-related bloodstream infections. Although...

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Autores principales:	Yutaka Kawakami, Takashi Tagami
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1cc0fed58893417e87ae4087d6b5a3df
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spelling	oai:doaj.org-article:1cc0fed58893417e87ae4087d6b5a3df2021-12-02T16:06:44ZPumping infusions with a syringe may cause contamination of the fluid in the syringe10.1038/s41598-021-94740-12045-2322https://doaj.org/article/1cc0fed58893417e87ae4087d6b5a3df2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94740-1https://doaj.org/toc/2045-2322Abstract Clinicians often perform pumping of infusions with a syringe (PIS) to quickly deliver fluid or blood transfusion to patients, especially during an emergency. Despite the efforts of the clinicians, critically ill patients are prone to acquire catheter-related bloodstream infections. Although clinicians have reported the possibility of PIS contamination, no group of researchers has studied nor confirmed this possibility. Here, we examined whether PIS can cause bacterial contamination of the fluid inside the syringes, using microbiological tests, including the analysis Escherichia coli DH-5 alpha growth by measuring the absorbance at OD600. We confirmed that contamination of fluid in the barrel was almost proportional to the applied volume of bacterial fluid. Aliquots of DH-5 alpha artificially applied on the surface of the gloved hand of an examiner, the plunger or the inner side of the barrel of a syringe could permeate inside the syringe. Furthermore, disinfection with ethanol before PIS almost successfully prevented bacterial multiplication. Our findings suggest that PIS can cause intraluminal contamination when performed with unsterilized hands, and that previous disinfection with ethanol can effectively prevent PIS-induced contamination. These results highlight the risk of PIS-induced contamination and the importance of disinfection in the daily clinical practice.Yutaka KawakamiTakashi TagamiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yutaka Kawakami Takashi Tagami Pumping infusions with a syringe may cause contamination of the fluid in the syringe
description	Abstract Clinicians often perform pumping of infusions with a syringe (PIS) to quickly deliver fluid or blood transfusion to patients, especially during an emergency. Despite the efforts of the clinicians, critically ill patients are prone to acquire catheter-related bloodstream infections. Although clinicians have reported the possibility of PIS contamination, no group of researchers has studied nor confirmed this possibility. Here, we examined whether PIS can cause bacterial contamination of the fluid inside the syringes, using microbiological tests, including the analysis Escherichia coli DH-5 alpha growth by measuring the absorbance at OD600. We confirmed that contamination of fluid in the barrel was almost proportional to the applied volume of bacterial fluid. Aliquots of DH-5 alpha artificially applied on the surface of the gloved hand of an examiner, the plunger or the inner side of the barrel of a syringe could permeate inside the syringe. Furthermore, disinfection with ethanol before PIS almost successfully prevented bacterial multiplication. Our findings suggest that PIS can cause intraluminal contamination when performed with unsterilized hands, and that previous disinfection with ethanol can effectively prevent PIS-induced contamination. These results highlight the risk of PIS-induced contamination and the importance of disinfection in the daily clinical practice.
format	article
author	Yutaka Kawakami Takashi Tagami
author_facet	Yutaka Kawakami Takashi Tagami
author_sort	Yutaka Kawakami
title	Pumping infusions with a syringe may cause contamination of the fluid in the syringe
title_short	Pumping infusions with a syringe may cause contamination of the fluid in the syringe
title_full	Pumping infusions with a syringe may cause contamination of the fluid in the syringe
title_fullStr	Pumping infusions with a syringe may cause contamination of the fluid in the syringe
title_full_unstemmed	Pumping infusions with a syringe may cause contamination of the fluid in the syringe
title_sort	pumping infusions with a syringe may cause contamination of the fluid in the syringe
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1cc0fed58893417e87ae4087d6b5a3df
work_keys_str_mv	AT yutakakawakami pumpinginfusionswithasyringemaycausecontaminationofthefluidinthesyringe AT takashitagami pumpinginfusionswithasyringemaycausecontaminationofthefluidinthesyringe
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Pumping infusions with a syringe may cause contamination of the fluid in the syringe

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