Low body mass is associated with reduced left ventricular mass in Chinese elderly with severe COPD

Abstract There is limited information on the association of body mass index (BMI) with left ventricular (LV) remodeling corresponding to severity of reduced lung function in patients with chronic obstructive pulmonary disease (COPD). Therefore, we investigated whether BMI is associated with cardiac...

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Autores principales:	Jing Zhang, Gang Li, Jari A. Laukkanen, Cheng Liu, Xing Song, Yuqi Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1cc3b5770e07406082000a16d5e30d67
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spelling	oai:doaj.org-article:1cc3b5770e07406082000a16d5e30d672021-12-02T18:02:54ZLow body mass is associated with reduced left ventricular mass in Chinese elderly with severe COPD10.1038/s41598-021-92212-02045-2322https://doaj.org/article/1cc3b5770e07406082000a16d5e30d672021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92212-0https://doaj.org/toc/2045-2322Abstract There is limited information on the association of body mass index (BMI) with left ventricular (LV) remodeling corresponding to severity of reduced lung function in patients with chronic obstructive pulmonary disease (COPD). Therefore, we investigated whether BMI is associated with cardiac atrial and ventricular dimensions according to severity of lung functional impairment in Chinese COPD elderly. A total of 563 hospitalized COPD patients with lung function impairment and 184 patients with non-COPD (aged 65–92 years) were collected retrospectively in a cross-sectional study in a university affiliated tertiary hospital in China. BMI and cardiac echocardiographic parameters were compared according to severity of lung functional impairment in COPD patients. BMI was 22.9 ± 3.9 kg/m2 in COPD patients, 24.0 ± 4.1 kg/m2 in non-COPD patients respectively. Reduced BMI, LV mass index, LV wall thickness and left atrial diameter, and dilated right ventricle (RV) existed in COPD patients with severe lung dysfunction as compared the COPD patients with mild to moderate lung functional reduction and non-COPD patients (P < 0.05), while there were no differences in BMI and echocardiographic parameters between the COPD patients with mild to moderate lung functional decline and non-COPD patients (P > 0.05). Logistic regression analysis showed that low BMI (BMI < 18.5 kg/m2) was correlated with reduced LV mass and wall thickness, dilated RV and reduced lung function in the COPD patients with severe lung dysfunction. In conclusion, this study demonstrates that lower BMI is associated not only with dilated RV and impaired pulmonary function, but also it is related to reduced LV mass in Asian COPD elderly with severe lung dysfunction.Jing ZhangGang LiJari A. LaukkanenCheng LiuXing SongYuqi ZhuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jing Zhang Gang Li Jari A. Laukkanen Cheng Liu Xing Song Yuqi Zhu Low body mass is associated with reduced left ventricular mass in Chinese elderly with severe COPD
description	Abstract There is limited information on the association of body mass index (BMI) with left ventricular (LV) remodeling corresponding to severity of reduced lung function in patients with chronic obstructive pulmonary disease (COPD). Therefore, we investigated whether BMI is associated with cardiac atrial and ventricular dimensions according to severity of lung functional impairment in Chinese COPD elderly. A total of 563 hospitalized COPD patients with lung function impairment and 184 patients with non-COPD (aged 65–92 years) were collected retrospectively in a cross-sectional study in a university affiliated tertiary hospital in China. BMI and cardiac echocardiographic parameters were compared according to severity of lung functional impairment in COPD patients. BMI was 22.9 ± 3.9 kg/m2 in COPD patients, 24.0 ± 4.1 kg/m2 in non-COPD patients respectively. Reduced BMI, LV mass index, LV wall thickness and left atrial diameter, and dilated right ventricle (RV) existed in COPD patients with severe lung dysfunction as compared the COPD patients with mild to moderate lung functional reduction and non-COPD patients (P < 0.05), while there were no differences in BMI and echocardiographic parameters between the COPD patients with mild to moderate lung functional decline and non-COPD patients (P > 0.05). Logistic regression analysis showed that low BMI (BMI < 18.5 kg/m2) was correlated with reduced LV mass and wall thickness, dilated RV and reduced lung function in the COPD patients with severe lung dysfunction. In conclusion, this study demonstrates that lower BMI is associated not only with dilated RV and impaired pulmonary function, but also it is related to reduced LV mass in Asian COPD elderly with severe lung dysfunction.
format	article
author	Jing Zhang Gang Li Jari A. Laukkanen Cheng Liu Xing Song Yuqi Zhu
author_facet	Jing Zhang Gang Li Jari A. Laukkanen Cheng Liu Xing Song Yuqi Zhu
author_sort	Jing Zhang
title	Low body mass is associated with reduced left ventricular mass in Chinese elderly with severe COPD
title_short	Low body mass is associated with reduced left ventricular mass in Chinese elderly with severe COPD
title_full	Low body mass is associated with reduced left ventricular mass in Chinese elderly with severe COPD
title_fullStr	Low body mass is associated with reduced left ventricular mass in Chinese elderly with severe COPD
title_full_unstemmed	Low body mass is associated with reduced left ventricular mass in Chinese elderly with severe COPD
title_sort	low body mass is associated with reduced left ventricular mass in chinese elderly with severe copd
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1cc3b5770e07406082000a16d5e30d67
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Low body mass is associated with reduced left ventricular mass in Chinese elderly with severe COPD

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