The evolution of the DLK1-DIO3 imprinted domain in mammals.

A comprehensive, domain-wide comparative analysis of genomic imprinting between mammals that imprint and those that do not can provide valuable information about how and why imprinting evolved. The imprinting status, DNA methylation, and genomic landscape of the Dlk1-Dio3 cluster were determined in...

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Autores principales:	Carol A Edwards, Andrew J Mungall, Lucy Matthews, Edward Ryder, Dionne J Gray, Andrew J Pask, Geoffrey Shaw, Jennifer A M Graves, Jane Rogers, SAVOIR consortium, Ian Dunham, Marilyn B Renfree, Anne C Ferguson-Smith
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1cc56e428ef442bd9ec9265423ddbf3a
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spelling	oai:doaj.org-article:1cc56e428ef442bd9ec9265423ddbf3a2021-12-02T19:54:30ZThe evolution of the DLK1-DIO3 imprinted domain in mammals.1544-91731545-788510.1371/journal.pbio.0060135https://doaj.org/article/1cc56e428ef442bd9ec9265423ddbf3a2008-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18532878/pdf/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885A comprehensive, domain-wide comparative analysis of genomic imprinting between mammals that imprint and those that do not can provide valuable information about how and why imprinting evolved. The imprinting status, DNA methylation, and genomic landscape of the Dlk1-Dio3 cluster were determined in eutherian, metatherian, and prototherian mammals including tammar wallaby and platypus. Imprinting across the whole domain evolved after the divergence of eutherian from marsupial mammals and in eutherians is under strong purifying selection. The marsupial locus at 1.6 megabases, is double that of eutherians due to the accumulation of LINE repeats. Comparative sequence analysis of the domain in seven vertebrates determined evolutionary conserved regions common to particular sub-groups and to all vertebrates. The emergence of Dlk1-Dio3 imprinting in eutherians has occurred on the maternally inherited chromosome and is associated with region-specific resistance to expansion by repetitive elements and the local introduction of noncoding transcripts including microRNAs and C/D small nucleolar RNAs. A recent mammal-specific retrotransposition event led to the formation of a completely new gene only in the eutherian domain, which may have driven imprinting at the cluster.Carol A EdwardsAndrew J MungallLucy MatthewsEdward RyderDionne J GrayAndrew J PaskGeoffrey ShawJennifer A M GravesJane RogersSAVOIR consortiumIan DunhamMarilyn B RenfreeAnne C Ferguson-SmithPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 6, Iss 6, p e135 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Carol A Edwards Andrew J Mungall Lucy Matthews Edward Ryder Dionne J Gray Andrew J Pask Geoffrey Shaw Jennifer A M Graves Jane Rogers SAVOIR consortium Ian Dunham Marilyn B Renfree Anne C Ferguson-Smith The evolution of the DLK1-DIO3 imprinted domain in mammals.
description	A comprehensive, domain-wide comparative analysis of genomic imprinting between mammals that imprint and those that do not can provide valuable information about how and why imprinting evolved. The imprinting status, DNA methylation, and genomic landscape of the Dlk1-Dio3 cluster were determined in eutherian, metatherian, and prototherian mammals including tammar wallaby and platypus. Imprinting across the whole domain evolved after the divergence of eutherian from marsupial mammals and in eutherians is under strong purifying selection. The marsupial locus at 1.6 megabases, is double that of eutherians due to the accumulation of LINE repeats. Comparative sequence analysis of the domain in seven vertebrates determined evolutionary conserved regions common to particular sub-groups and to all vertebrates. The emergence of Dlk1-Dio3 imprinting in eutherians has occurred on the maternally inherited chromosome and is associated with region-specific resistance to expansion by repetitive elements and the local introduction of noncoding transcripts including microRNAs and C/D small nucleolar RNAs. A recent mammal-specific retrotransposition event led to the formation of a completely new gene only in the eutherian domain, which may have driven imprinting at the cluster.
format	article
author	Carol A Edwards Andrew J Mungall Lucy Matthews Edward Ryder Dionne J Gray Andrew J Pask Geoffrey Shaw Jennifer A M Graves Jane Rogers SAVOIR consortium Ian Dunham Marilyn B Renfree Anne C Ferguson-Smith
author_facet	Carol A Edwards Andrew J Mungall Lucy Matthews Edward Ryder Dionne J Gray Andrew J Pask Geoffrey Shaw Jennifer A M Graves Jane Rogers SAVOIR consortium Ian Dunham Marilyn B Renfree Anne C Ferguson-Smith
author_sort	Carol A Edwards
title	The evolution of the DLK1-DIO3 imprinted domain in mammals.
title_short	The evolution of the DLK1-DIO3 imprinted domain in mammals.
title_full	The evolution of the DLK1-DIO3 imprinted domain in mammals.
title_fullStr	The evolution of the DLK1-DIO3 imprinted domain in mammals.
title_full_unstemmed	The evolution of the DLK1-DIO3 imprinted domain in mammals.
title_sort	evolution of the dlk1-dio3 imprinted domain in mammals.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/1cc56e428ef442bd9ec9265423ddbf3a
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The evolution of the DLK1-DIO3 imprinted domain in mammals.

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