Family History of Psychiatric Disorders and Clinical Factors Associated With a Schizophrenia Diagnosis

Background Schizophrenia (SCH) and bipolar disorder (BD) have both shared and unique genetic risk factors and clinical characteristics. The aim of the present study was to identify potential risk factors significantly associated with SCH, relative to a BD reference group. Methods Data were obtained...

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Autores principales:	Lina Díaz-Castro MD, PhD, Kurt Hoffman PhD, Héctor Cabello-Rangel MD, PhD, Armando Arredondo MD, PhD, Miguel Ángel Herrera-Estrella MD
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/1cc64a97169b4f41984acbb1ba086f45
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spelling	oai:doaj.org-article:1cc64a97169b4f41984acbb1ba086f452021-12-01T22:35:01ZFamily History of Psychiatric Disorders and Clinical Factors Associated With a Schizophrenia Diagnosis0046-95801945-724310.1177/00469580211060797https://doaj.org/article/1cc64a97169b4f41984acbb1ba086f452021-11-01T00:00:00Zhttps://doi.org/10.1177/00469580211060797https://doaj.org/toc/0046-9580https://doaj.org/toc/1945-7243Background Schizophrenia (SCH) and bipolar disorder (BD) have both shared and unique genetic risk factors and clinical characteristics. The aim of the present study was to identify potential risk factors significantly associated with SCH, relative to a BD reference group. Methods Data were obtained from medical records of patients that entered a major Mexico City hospital during 2009–2010 presenting psychotic symptoms (n = 1132; 830 cases of SCH, 302 cases of BD; 714 men and 418 women). SCH and BD diagnoses were compared with respect to a number of family and clinical characteristics. Logistic and linear regression analyses were used to respectively identify factors selectively associated with the SCH diagnosis relative to the BD diagnosis and explore the relationship between PANSS scores and parental age at time of birth to the age of SCH onset. Results Patients with SCH showed greater functional impairment than those with BD. Family history of mental illness, premorbid schizoid-like personality, and obstetric trauma were significantly associated with the SCH diagnosis. The association of obstetric trauma with SCH was greatest in male patients with a family history of mental illness. In women, increased paternal and decreased maternal age at time of the patient’s birth were associated with an earlier age of SCH onset. Conclusion Male gender, showing premorbid schizoid-like personality, familial SCH, and obstetric trauma are risk factors that distinguish SCH from BD. Additionally, our results suggest that risk for SCH relative to BD may be importantly influenced by interactions between familial risk, gender, and obstetric trauma.Lina Díaz-Castro MD, PhDKurt Hoffman PhDHéctor Cabello-Rangel MD, PhDArmando Arredondo MD, PhDMiguel Ángel Herrera-Estrella MDSAGE PublishingarticlePublic aspects of medicineRA1-1270ENInquiry: The Journal of Health Care Organization, Provision, and Financing, Vol 58 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Public aspects of medicine RA1-1270
spellingShingle	Public aspects of medicine RA1-1270 Lina Díaz-Castro MD, PhD Kurt Hoffman PhD Héctor Cabello-Rangel MD, PhD Armando Arredondo MD, PhD Miguel Ángel Herrera-Estrella MD Family History of Psychiatric Disorders and Clinical Factors Associated With a Schizophrenia Diagnosis
description	Background Schizophrenia (SCH) and bipolar disorder (BD) have both shared and unique genetic risk factors and clinical characteristics. The aim of the present study was to identify potential risk factors significantly associated with SCH, relative to a BD reference group. Methods Data were obtained from medical records of patients that entered a major Mexico City hospital during 2009–2010 presenting psychotic symptoms (n = 1132; 830 cases of SCH, 302 cases of BD; 714 men and 418 women). SCH and BD diagnoses were compared with respect to a number of family and clinical characteristics. Logistic and linear regression analyses were used to respectively identify factors selectively associated with the SCH diagnosis relative to the BD diagnosis and explore the relationship between PANSS scores and parental age at time of birth to the age of SCH onset. Results Patients with SCH showed greater functional impairment than those with BD. Family history of mental illness, premorbid schizoid-like personality, and obstetric trauma were significantly associated with the SCH diagnosis. The association of obstetric trauma with SCH was greatest in male patients with a family history of mental illness. In women, increased paternal and decreased maternal age at time of the patient’s birth were associated with an earlier age of SCH onset. Conclusion Male gender, showing premorbid schizoid-like personality, familial SCH, and obstetric trauma are risk factors that distinguish SCH from BD. Additionally, our results suggest that risk for SCH relative to BD may be importantly influenced by interactions between familial risk, gender, and obstetric trauma.
format	article
author	Lina Díaz-Castro MD, PhD Kurt Hoffman PhD Héctor Cabello-Rangel MD, PhD Armando Arredondo MD, PhD Miguel Ángel Herrera-Estrella MD
author_facet	Lina Díaz-Castro MD, PhD Kurt Hoffman PhD Héctor Cabello-Rangel MD, PhD Armando Arredondo MD, PhD Miguel Ángel Herrera-Estrella MD
author_sort	Lina Díaz-Castro MD, PhD
title	Family History of Psychiatric Disorders and Clinical Factors Associated With a Schizophrenia Diagnosis
title_short	Family History of Psychiatric Disorders and Clinical Factors Associated With a Schizophrenia Diagnosis
title_full	Family History of Psychiatric Disorders and Clinical Factors Associated With a Schizophrenia Diagnosis
title_fullStr	Family History of Psychiatric Disorders and Clinical Factors Associated With a Schizophrenia Diagnosis
title_full_unstemmed	Family History of Psychiatric Disorders and Clinical Factors Associated With a Schizophrenia Diagnosis
title_sort	family history of psychiatric disorders and clinical factors associated with a schizophrenia diagnosis
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/1cc64a97169b4f41984acbb1ba086f45
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Family History of Psychiatric Disorders and Clinical Factors Associated With a Schizophrenia Diagnosis

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