Measuring single cell divisions in human tissues from multi-region sequencing data
Quantifying somatic evolutionary processes in cancer and healthy tissue is a challenge. Here, the authors use single time point multi-region sampling of cancer and normal tissue, combined with evolutionary theory, to quantify in vivo mutation and cell survival rates per cell division.
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Autores principales: | Benjamin Werner, Jack Case, Marc J. Williams, Ketevan Chkhaidze, Daniel Temko, Javier Fernández-Mateos, George D. Cresswell, Daniel Nichol, William Cross, Inmaculada Spiteri, Weini Huang, Ian P. M. Tomlinson, Chris P. Barnes, Trevor A. Graham, Andrea Sottoriva |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
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Materias: | |
Acceso en línea: | https://doaj.org/article/1cc8e57a38b3428da9bd484790ebf103 |
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