Clinical and diagnostic aspects of deep infiltrative endometriosis (diagnosis, treatment, recurrence)

Aim. To analyze the recurrence of endometriosis after surgical treatment of patients with deep endometriosis. Materials and methods. The case histories of 90 patients aged 19 to 45 years were retrospectively analyzed. The study group consisted of 70 endometriosis patients: 20 with peritoneal endo...

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Autores principales:	Shakhnoza K. Muftaidinova, Leonid Z. Faizullin, Vladimir D. Chuprynin, Nikolai S. Ruseikin, Tatiana I. Smolnova, Natalia A. Buralkina
Formato:	article
Lenguaje:	RU
Publicado:	IP Berlin A.V. 2021
Materias:	deep infiltrative endometriosis recurrence oncomarkers hormonal therapy Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/1ccb3a6992df4302a8cfffd10772a698
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spelling	oai:doaj.org-article:1ccb3a6992df4302a8cfffd10772a6982021-12-02T19:22:24ZClinical and diagnostic aspects of deep infiltrative endometriosis (diagnosis, treatment, recurrence)2079-56962079-583110.26442/20795696.2021.4.201040https://doaj.org/article/1ccb3a6992df4302a8cfffd10772a6982021-09-01T00:00:00Zhttps://gynecology.orscience.ru/2079-5831/article/viewFile/80228/60774https://doaj.org/toc/2079-5696https://doaj.org/toc/2079-5831Aim. To analyze the recurrence of endometriosis after surgical treatment of patients with deep endometriosis. Materials and methods. The case histories of 90 patients aged 19 to 45 years were retrospectively analyzed. The study group consisted of 70 endometriosis patients: 20 with peritoneal endometriosis and 50 with deep infiltrative endometriosis (DIЕ). The comparison group included 20 women without endometriosis. There was an in-depth study of anamnestic data in the cohort of patients under study. The results of preoperative laboratory tests, including serum levels of the CA-125 and CA 19-9 oncomarkers, were processed. Results. Analysis of the obtained data showed that about half of the DIE patients (54%) in the main group had a history of surgical interventions for endometriosis. The number of operations was significantly higher in patients compared to the peritoneal endometriosis group (68% vs 20%, respectively; р=0.0012). Two subgroups were formed from the group of women with DIE: patients who had no history of previous surgical treatment for endometriosis and those hospitalized for repeated surgical treatment of endometriosis (patients with recurrent endometriosis). Patients with recurrent endometriosis had a significantly higher incidence of heavy menstruation, pregnancy terminations (abortions), and a high proportion of gastrointestinal diseases. Analysis of the hormonal therapy received in patients with DIE showed that every second patient with relapses (18/53%) after surgical treatment and every third patient without a prior history of surgery (5/31%) received hormonal therapy. Examination of the preoperative serum levels of CA-125 and CA 19-9 serum markers in patients with DIE showed an increase in their serum levels and a correlation with the frequency of endometriosis recurrence and the size of DIE foci. Conclusion. Despite the conservative and surgical treatment of DIE patients, the recurrence rate is still high. At present, there is no satisfactory therapy for all endometriosis patients. Therefore, the development of therapy for the conservative treatment of the disease remains an urgent task.Shakhnoza K. MuftaidinovaLeonid Z. FaizullinVladimir D. ChupryninNikolai S. RuseikinTatiana I. SmolnovaNatalia A. BuralkinaIP Berlin A.V. articledeep infiltrative endometriosisrecurrenceoncomarkershormonal therapyGynecology and obstetricsRG1-991RUГинекология, Vol 23, Iss 4, Pp 307-313 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	deep infiltrative endometriosis recurrence oncomarkers hormonal therapy Gynecology and obstetrics RG1-991
spellingShingle	deep infiltrative endometriosis recurrence oncomarkers hormonal therapy Gynecology and obstetrics RG1-991 Shakhnoza K. Muftaidinova Leonid Z. Faizullin Vladimir D. Chuprynin Nikolai S. Ruseikin Tatiana I. Smolnova Natalia A. Buralkina Clinical and diagnostic aspects of deep infiltrative endometriosis (diagnosis, treatment, recurrence)
description	Aim. To analyze the recurrence of endometriosis after surgical treatment of patients with deep endometriosis. Materials and methods. The case histories of 90 patients aged 19 to 45 years were retrospectively analyzed. The study group consisted of 70 endometriosis patients: 20 with peritoneal endometriosis and 50 with deep infiltrative endometriosis (DIЕ). The comparison group included 20 women without endometriosis. There was an in-depth study of anamnestic data in the cohort of patients under study. The results of preoperative laboratory tests, including serum levels of the CA-125 and CA 19-9 oncomarkers, were processed. Results. Analysis of the obtained data showed that about half of the DIE patients (54%) in the main group had a history of surgical interventions for endometriosis. The number of operations was significantly higher in patients compared to the peritoneal endometriosis group (68% vs 20%, respectively; р=0.0012). Two subgroups were formed from the group of women with DIE: patients who had no history of previous surgical treatment for endometriosis and those hospitalized for repeated surgical treatment of endometriosis (patients with recurrent endometriosis). Patients with recurrent endometriosis had a significantly higher incidence of heavy menstruation, pregnancy terminations (abortions), and a high proportion of gastrointestinal diseases. Analysis of the hormonal therapy received in patients with DIE showed that every second patient with relapses (18/53%) after surgical treatment and every third patient without a prior history of surgery (5/31%) received hormonal therapy. Examination of the preoperative serum levels of CA-125 and CA 19-9 serum markers in patients with DIE showed an increase in their serum levels and a correlation with the frequency of endometriosis recurrence and the size of DIE foci. Conclusion. Despite the conservative and surgical treatment of DIE patients, the recurrence rate is still high. At present, there is no satisfactory therapy for all endometriosis patients. Therefore, the development of therapy for the conservative treatment of the disease remains an urgent task.
format	article
author	Shakhnoza K. Muftaidinova Leonid Z. Faizullin Vladimir D. Chuprynin Nikolai S. Ruseikin Tatiana I. Smolnova Natalia A. Buralkina
author_facet	Shakhnoza K. Muftaidinova Leonid Z. Faizullin Vladimir D. Chuprynin Nikolai S. Ruseikin Tatiana I. Smolnova Natalia A. Buralkina
author_sort	Shakhnoza K. Muftaidinova
title	Clinical and diagnostic aspects of deep infiltrative endometriosis (diagnosis, treatment, recurrence)
title_short	Clinical and diagnostic aspects of deep infiltrative endometriosis (diagnosis, treatment, recurrence)
title_full	Clinical and diagnostic aspects of deep infiltrative endometriosis (diagnosis, treatment, recurrence)
title_fullStr	Clinical and diagnostic aspects of deep infiltrative endometriosis (diagnosis, treatment, recurrence)
title_full_unstemmed	Clinical and diagnostic aspects of deep infiltrative endometriosis (diagnosis, treatment, recurrence)
title_sort	clinical and diagnostic aspects of deep infiltrative endometriosis (diagnosis, treatment, recurrence)
publisher	IP Berlin A.V.
publishDate	2021
url	https://doaj.org/article/1ccb3a6992df4302a8cfffd10772a698
work_keys_str_mv	AT shakhnozakmuftaidinova clinicalanddiagnosticaspectsofdeepinfiltrativeendometriosisdiagnosistreatmentrecurrence AT leonidzfaizullin clinicalanddiagnosticaspectsofdeepinfiltrativeendometriosisdiagnosistreatmentrecurrence AT vladimirdchuprynin clinicalanddiagnosticaspectsofdeepinfiltrativeendometriosisdiagnosistreatmentrecurrence AT nikolaisruseikin clinicalanddiagnosticaspectsofdeepinfiltrativeendometriosisdiagnosistreatmentrecurrence AT tatianaismolnova clinicalanddiagnosticaspectsofdeepinfiltrativeendometriosisdiagnosistreatmentrecurrence AT nataliaaburalkina clinicalanddiagnosticaspectsofdeepinfiltrativeendometriosisdiagnosistreatmentrecurrence
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Clinical and diagnostic aspects of deep infiltrative endometriosis (diagnosis, treatment, recurrence)

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