Pallidal versus subthalamic deep-brain stimulation for meige syndrome: a retrospective study

Abstract Deep-brain stimulation (DBS) is an effective treatment for patients with Meige syndrome. The globus pallidus interna (GPi) and the subthalamic nucleus (STN) are accepted targets for this treatment. We compared 12-month outcomes for patients who had undergone bilateral stimulation of the GPi...

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Autores principales:	Jiayu Liu, Hu Ding, Ke Xu, Ruen Liu, Dongliang Wang, Jia Ouyang, Zhi Liu, Zeyu Miao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ccbaf2df7644bd09321d23dc3363e07
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spelling	oai:doaj.org-article:1ccbaf2df7644bd09321d23dc3363e072021-12-02T17:32:58ZPallidal versus subthalamic deep-brain stimulation for meige syndrome: a retrospective study10.1038/s41598-021-88384-42045-2322https://doaj.org/article/1ccbaf2df7644bd09321d23dc3363e072021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88384-4https://doaj.org/toc/2045-2322Abstract Deep-brain stimulation (DBS) is an effective treatment for patients with Meige syndrome. The globus pallidus interna (GPi) and the subthalamic nucleus (STN) are accepted targets for this treatment. We compared 12-month outcomes for patients who had undergone bilateral stimulation of the GPi or STN. Forty-two Asian patients with primary Meige syndrome who underwent GPi or STN neurostimulation were recruited between September 2017 and September 2019 at the Department of Neurosurgery, Peking University People’s Hospital. The primary outcome was the change in motor function, including the Burke–Fahn–Marsden Dystonia Rating Scale movement (BFMDRS-M) and disability subscale (BFMDRS-D) at 3 days before DBS (baseline) surgery and 1, 3, 6, and 12 months after surgery. Secondary outcomes included health-related quality of life, sleep quality status, depression severity, and anxiety severity at 3 days before and 12 months after DBS surgery. Adverse events during the 12 months were also recorded. Changes in BFMDRS-M and BFMDRS-D scores at 1, 3, 6, and 12 months with DBS and without medication did not significantly differ based on the stimulation target. There were also no significant differences in the changes in health-related quality of life (36-Item Short-Form General Health Survey) and sleep quality status (Pittsburgh Sleep Quality Index) at 12 months. However, there were larger improvements in the STN than the GPi group in mean score changes on the 17-item Hamilton depression rating scale (− 3.38 vs. − 0.33 points; P = 0.014) and 14-item Hamilton anxiety rating scale (− 3.43 vs. − 0.19 points; P < 0.001). There were no significant between-group differences in the frequency or type of serious adverse events. Patients with Meige syndrome had similar improvements in motor function, quality of life and sleep after either pallidal or subthalamic stimulation. Depression and anxiety factors may reasonably be included during the selection of DBS targets for Meige syndrome.Jiayu LiuHu DingKe XuRuen LiuDongliang WangJia OuyangZhi LiuZeyu MiaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiayu Liu Hu Ding Ke Xu Ruen Liu Dongliang Wang Jia Ouyang Zhi Liu Zeyu Miao Pallidal versus subthalamic deep-brain stimulation for meige syndrome: a retrospective study
description	Abstract Deep-brain stimulation (DBS) is an effective treatment for patients with Meige syndrome. The globus pallidus interna (GPi) and the subthalamic nucleus (STN) are accepted targets for this treatment. We compared 12-month outcomes for patients who had undergone bilateral stimulation of the GPi or STN. Forty-two Asian patients with primary Meige syndrome who underwent GPi or STN neurostimulation were recruited between September 2017 and September 2019 at the Department of Neurosurgery, Peking University People’s Hospital. The primary outcome was the change in motor function, including the Burke–Fahn–Marsden Dystonia Rating Scale movement (BFMDRS-M) and disability subscale (BFMDRS-D) at 3 days before DBS (baseline) surgery and 1, 3, 6, and 12 months after surgery. Secondary outcomes included health-related quality of life, sleep quality status, depression severity, and anxiety severity at 3 days before and 12 months after DBS surgery. Adverse events during the 12 months were also recorded. Changes in BFMDRS-M and BFMDRS-D scores at 1, 3, 6, and 12 months with DBS and without medication did not significantly differ based on the stimulation target. There were also no significant differences in the changes in health-related quality of life (36-Item Short-Form General Health Survey) and sleep quality status (Pittsburgh Sleep Quality Index) at 12 months. However, there were larger improvements in the STN than the GPi group in mean score changes on the 17-item Hamilton depression rating scale (− 3.38 vs. − 0.33 points; P = 0.014) and 14-item Hamilton anxiety rating scale (− 3.43 vs. − 0.19 points; P < 0.001). There were no significant between-group differences in the frequency or type of serious adverse events. Patients with Meige syndrome had similar improvements in motor function, quality of life and sleep after either pallidal or subthalamic stimulation. Depression and anxiety factors may reasonably be included during the selection of DBS targets for Meige syndrome.
format	article
author	Jiayu Liu Hu Ding Ke Xu Ruen Liu Dongliang Wang Jia Ouyang Zhi Liu Zeyu Miao
author_facet	Jiayu Liu Hu Ding Ke Xu Ruen Liu Dongliang Wang Jia Ouyang Zhi Liu Zeyu Miao
author_sort	Jiayu Liu
title	Pallidal versus subthalamic deep-brain stimulation for meige syndrome: a retrospective study
title_short	Pallidal versus subthalamic deep-brain stimulation for meige syndrome: a retrospective study
title_full	Pallidal versus subthalamic deep-brain stimulation for meige syndrome: a retrospective study
title_fullStr	Pallidal versus subthalamic deep-brain stimulation for meige syndrome: a retrospective study
title_full_unstemmed	Pallidal versus subthalamic deep-brain stimulation for meige syndrome: a retrospective study
title_sort	pallidal versus subthalamic deep-brain stimulation for meige syndrome: a retrospective study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1ccbaf2df7644bd09321d23dc3363e07
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Pallidal versus subthalamic deep-brain stimulation for meige syndrome: a retrospective study

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