Histological study of the biodynamics of iron oxide nanoparticles with different diameters

Keiko Tsuchiya1, Norihisa Nitta1, Akinaga Sonoda1, Ayumi Nitta-Seko1, Shinichi Ohta1, Hideji Otani1, Masashi Takahashi1, Kiyoshi Murata1, Katsutoshi Murase2, Satoshi Nohara2, Kenichi Mukaisho31Department of Radiology, Shiga University of Medical Science, Otsu, Shiga, 2The Nagoya Research Laboratory,...

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Autores principales:	Tsuchiya K, Nitta N, Sonoda A, Nitta-Seko A, Ohta S, Otani H, Takahashi M, Murata K, Murase K, Nohara S, Mukaisho K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1ccc298cbb0945319597bbe2a38b9cb2
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spelling	oai:doaj.org-article:1ccc298cbb0945319597bbe2a38b9cb22021-12-02T00:43:05ZHistological study of the biodynamics of iron oxide nanoparticles with different diameters1176-91141178-2013https://doaj.org/article/1ccc298cbb0945319597bbe2a38b9cb22011-08-01T00:00:00Zhttp://www.dovepress.com/histological-study-of-the-biodynamics-of-iron-oxide-nanoparticles-with-a8003https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Keiko Tsuchiya1, Norihisa Nitta1, Akinaga Sonoda1, Ayumi Nitta-Seko1, Shinichi Ohta1, Hideji Otani1, Masashi Takahashi1, Kiyoshi Murata1, Katsutoshi Murase2, Satoshi Nohara2, Kenichi Mukaisho31Department of Radiology, Shiga University of Medical Science, Otsu, Shiga, 2The Nagoya Research Laboratory, Meito Sangyo Co, Ltd, Kiyosu, Aichi, 3Department of Pathology, Shiga University of Medical Science, Otsu, Shiga, JapanAbstract: The biodynamics of ultrasmall and small superparamagnetic iron oxide (USPIO and SPIO, respectively) particles that were injected intraperitoneally into 36 C57BL/6 mice were investigated chronologically. Their distribution was studied histologically at six time points by measuring iron-positive areas (&micro;m2) in organ sections stained with Prussian blue. The uptake of the differently sized particles was also compared by cultured murine macrophages (J774.1). Iron-positive areas in the liver were significantly larger in the mice injected with USPIO than those injected with SPIO at the first three time points (P &lt; 0.05). The amount of USPIO in the lung parenchyma around the airway was larger than that of SPIO at four time points (P &lt; 0.05); distribution to the lymph nodes was not significantly different. The amount of iron was significantly larger in SPIO- than USPIO-treated cultured cells (P &lt; 0.05). In conclusion, it is suggested that intra peritoneally injected USPIO particles could be used more quickly than SPIO to make Kupffer images of the liver and that both agents could help get lymph node images of similar quality.Keywords: USPIO, SPIO, contrast agent, biodistribution, histologyTsuchiya KNitta NSonoda ANitta-Seko AOhta SOtani HTakahashi MMurata KMurase KNohara SMukaisho KDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 1587-1594 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Tsuchiya K Nitta N Sonoda A Nitta-Seko A Ohta S Otani H Takahashi M Murata K Murase K Nohara S Mukaisho K Histological study of the biodynamics of iron oxide nanoparticles with different diameters
description	Keiko Tsuchiya1, Norihisa Nitta1, Akinaga Sonoda1, Ayumi Nitta-Seko1, Shinichi Ohta1, Hideji Otani1, Masashi Takahashi1, Kiyoshi Murata1, Katsutoshi Murase2, Satoshi Nohara2, Kenichi Mukaisho31Department of Radiology, Shiga University of Medical Science, Otsu, Shiga, 2The Nagoya Research Laboratory, Meito Sangyo Co, Ltd, Kiyosu, Aichi, 3Department of Pathology, Shiga University of Medical Science, Otsu, Shiga, JapanAbstract: The biodynamics of ultrasmall and small superparamagnetic iron oxide (USPIO and SPIO, respectively) particles that were injected intraperitoneally into 36 C57BL/6 mice were investigated chronologically. Their distribution was studied histologically at six time points by measuring iron-positive areas (&micro;m2) in organ sections stained with Prussian blue. The uptake of the differently sized particles was also compared by cultured murine macrophages (J774.1). Iron-positive areas in the liver were significantly larger in the mice injected with USPIO than those injected with SPIO at the first three time points (P &lt; 0.05). The amount of USPIO in the lung parenchyma around the airway was larger than that of SPIO at four time points (P &lt; 0.05); distribution to the lymph nodes was not significantly different. The amount of iron was significantly larger in SPIO- than USPIO-treated cultured cells (P &lt; 0.05). In conclusion, it is suggested that intra peritoneally injected USPIO particles could be used more quickly than SPIO to make Kupffer images of the liver and that both agents could help get lymph node images of similar quality.Keywords: USPIO, SPIO, contrast agent, biodistribution, histology
format	article
author	Tsuchiya K Nitta N Sonoda A Nitta-Seko A Ohta S Otani H Takahashi M Murata K Murase K Nohara S Mukaisho K
author_facet	Tsuchiya K Nitta N Sonoda A Nitta-Seko A Ohta S Otani H Takahashi M Murata K Murase K Nohara S Mukaisho K
author_sort	Tsuchiya K
title	Histological study of the biodynamics of iron oxide nanoparticles with different diameters
title_short	Histological study of the biodynamics of iron oxide nanoparticles with different diameters
title_full	Histological study of the biodynamics of iron oxide nanoparticles with different diameters
title_fullStr	Histological study of the biodynamics of iron oxide nanoparticles with different diameters
title_full_unstemmed	Histological study of the biodynamics of iron oxide nanoparticles with different diameters
title_sort	histological study of the biodynamics of iron oxide nanoparticles with different diameters
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/1ccc298cbb0945319597bbe2a38b9cb2
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Histological study of the biodynamics of iron oxide nanoparticles with different diameters

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