Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing

The functional significance of start site choice in promoter architectures is little understood. Here the authors identify in zebrafish development and mammalian cells a class of dual-initiation promoters, in which non-canonical YC dinucleotides reflecting 5’-TOP/TCT initiation are intertwined with...

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Autores principales:	Chirag Nepal, Yavor Hadzhiev, Piotr Balwierz, Estefanía Tarifeño-Saldivia, Ryan Cardenas, Joseph W. Wragg, Ana-Maria Suzuki, Piero Carninci, Bernard Peers, Boris Lenhard, Jesper B. Andersen, Ferenc Müller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1ccdccedb09b4f3faf2cec376a66c412
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spelling	oai:doaj.org-article:1ccdccedb09b4f3faf2cec376a66c4122021-12-02T14:41:14ZDual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing10.1038/s41467-019-13687-02041-1723https://doaj.org/article/1ccdccedb09b4f3faf2cec376a66c4122020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13687-0https://doaj.org/toc/2041-1723The functional significance of start site choice in promoter architectures is little understood. Here the authors identify in zebrafish development and mammalian cells a class of dual-initiation promoters, in which non-canonical YC dinucleotides reflecting 5’-TOP/TCT initiation are intertwined with canonical YR-initiation.Chirag NepalYavor HadzhievPiotr BalwierzEstefanía Tarifeño-SaldiviaRyan CardenasJoseph W. WraggAna-Maria SuzukiPiero CarninciBernard PeersBoris LenhardJesper B. AndersenFerenc MüllerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chirag Nepal Yavor Hadzhiev Piotr Balwierz Estefanía Tarifeño-Saldivia Ryan Cardenas Joseph W. Wragg Ana-Maria Suzuki Piero Carninci Bernard Peers Boris Lenhard Jesper B. Andersen Ferenc Müller Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing
description	The functional significance of start site choice in promoter architectures is little understood. Here the authors identify in zebrafish development and mammalian cells a class of dual-initiation promoters, in which non-canonical YC dinucleotides reflecting 5’-TOP/TCT initiation are intertwined with canonical YR-initiation.
format	article
author	Chirag Nepal Yavor Hadzhiev Piotr Balwierz Estefanía Tarifeño-Saldivia Ryan Cardenas Joseph W. Wragg Ana-Maria Suzuki Piero Carninci Bernard Peers Boris Lenhard Jesper B. Andersen Ferenc Müller
author_facet	Chirag Nepal Yavor Hadzhiev Piotr Balwierz Estefanía Tarifeño-Saldivia Ryan Cardenas Joseph W. Wragg Ana-Maria Suzuki Piero Carninci Bernard Peers Boris Lenhard Jesper B. Andersen Ferenc Müller
author_sort	Chirag Nepal
title	Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing
title_short	Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing
title_full	Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing
title_fullStr	Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing
title_full_unstemmed	Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing
title_sort	dual-initiation promoters with intertwined canonical and tct/top transcription start sites diversify transcript processing
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1ccdccedb09b4f3faf2cec376a66c412
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Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing

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