Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer

Parul Gupta,1 Manjri Singh,2 Rajiv Kumar,3 Jodi Belz,3 Rishi Shanker,4 Premendra D Dwivedi,1 Srinivas Sridhar,3 Surinder P Singh2 1CSIR-Indian Institute of Toxicological Research, Lucknow, 2CSIR-National Physical Laboratory, New Delhi, India; 3Nanomedicine Science and Technology Center, Northeaster...

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Autores principales:	Gupta P, Singh M, Kumar R, Belz J, Shanker R, Dwivedi PD, Sridhar S, Singh SP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Docetaxel PLGA nanoformulation Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1cce35d8c30f430c896b2d8bb155ef79
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spelling	oai:doaj.org-article:1cce35d8c30f430c896b2d8bb155ef792021-12-02T02:52:35ZSynthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer1178-2013https://doaj.org/article/1cce35d8c30f430c896b2d8bb155ef792018-03-01T00:00:00Zhttps://www.dovepress.com/synthesis-and-in-vitro-studies-of-plga-dtx-nanoconjugate-as-potential--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Parul Gupta,1 Manjri Singh,2 Rajiv Kumar,3 Jodi Belz,3 Rishi Shanker,4 Premendra D Dwivedi,1 Srinivas Sridhar,3 Surinder P Singh2 1CSIR-Indian Institute of Toxicological Research, Lucknow, 2CSIR-National Physical Laboratory, New Delhi, India; 3Nanomedicine Science and Technology Center, Northeastern University, Boston, MA, USA; 4Institute of Life Sciences, Ahmedabad University, Ahmedabad, India Abstract: Advances in nanotechnology have led to the design of multifunctional nanoparticles capable of cellular imaging, targeted drug delivery, and diagnostics for early cancer detection. We synthesized poly(lactic-co-glycolic acid) nanoparticles encapsulating a model radiosensitizing drug docetaxel accomplishing localized in situ delivery of the sensitizer to the tumor site. The synthesized nanoparticles have been characterized for their physicochemical properties. The in vitro cytotoxicity of drug-loaded nanoparticles has been studied on human tongue carcinoma cell line SCC-9 (ATCC-CRL-1629). Keywords: docetaxel, PLGA nanoformulationGupta PSingh MKumar RBelz JShanker RDwivedi PDSridhar SSingh SPDove Medical PressarticleDocetaxelPLGA nanoformulationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 67-69 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Docetaxel PLGA nanoformulation Medicine (General) R5-920
spellingShingle	Docetaxel PLGA nanoformulation Medicine (General) R5-920 Gupta P Singh M Kumar R Belz J Shanker R Dwivedi PD Sridhar S Singh SP Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer
description	Parul Gupta,1 Manjri Singh,2 Rajiv Kumar,3 Jodi Belz,3 Rishi Shanker,4 Premendra D Dwivedi,1 Srinivas Sridhar,3 Surinder P Singh2 1CSIR-Indian Institute of Toxicological Research, Lucknow, 2CSIR-National Physical Laboratory, New Delhi, India; 3Nanomedicine Science and Technology Center, Northeastern University, Boston, MA, USA; 4Institute of Life Sciences, Ahmedabad University, Ahmedabad, India Abstract: Advances in nanotechnology have led to the design of multifunctional nanoparticles capable of cellular imaging, targeted drug delivery, and diagnostics for early cancer detection. We synthesized poly(lactic-co-glycolic acid) nanoparticles encapsulating a model radiosensitizing drug docetaxel accomplishing localized in situ delivery of the sensitizer to the tumor site. The synthesized nanoparticles have been characterized for their physicochemical properties. The in vitro cytotoxicity of drug-loaded nanoparticles has been studied on human tongue carcinoma cell line SCC-9 (ATCC-CRL-1629). Keywords: docetaxel, PLGA nanoformulation
format	article
author	Gupta P Singh M Kumar R Belz J Shanker R Dwivedi PD Sridhar S Singh SP
author_facet	Gupta P Singh M Kumar R Belz J Shanker R Dwivedi PD Sridhar S Singh SP
author_sort	Gupta P
title	Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer
title_short	Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer
title_full	Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer
title_fullStr	Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer
title_full_unstemmed	Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer
title_sort	synthesis and in vitro studies of plga-dtx nanoconjugate as potential drug delivery vehicle for oral cancer
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/1cce35d8c30f430c896b2d8bb155ef79
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_version_	1718402088633892864

Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer

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