Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears

Abstract Experimental studies suggest involvement of trimethylamine N-oxide (TMAO) in the aetiology of cardiometabolic diseases and chronic kidney disease (CKD), in part via metabolism of ingested food. Using a comparative biomimetic approach, we have investigated circulating levels of the gut metab...

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Autores principales:	Thomas Ebert, Johanna Painer, Peter Bergman, Abdul Rashid Qureshi, Sylvain Giroud, Gabrielle Stalder, Karolina Kublickiene, Frank Göritz, Sebastian Vetter, Claudia Bieber, Ole Fröbert, Jon M. Arnemo, Andreas Zedrosser, Irene Redtenbacher, Paul G. Shiels, Richard J. Johnson, Peter Stenvinkel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ccf685f5a4d46ca94fdc9cd039dc816
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spelling	oai:doaj.org-article:1ccf685f5a4d46ca94fdc9cd039dc8162021-12-02T12:34:17ZInsights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears10.1038/s41598-020-76346-12045-2322https://doaj.org/article/1ccf685f5a4d46ca94fdc9cd039dc8162020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-76346-1https://doaj.org/toc/2045-2322Abstract Experimental studies suggest involvement of trimethylamine N-oxide (TMAO) in the aetiology of cardiometabolic diseases and chronic kidney disease (CKD), in part via metabolism of ingested food. Using a comparative biomimetic approach, we have investigated circulating levels of the gut metabolites betaine, choline, and TMAO in human CKD, across animal species as well as during hibernation in two animal species. Betaine, choline, and TMAO levels were associated with renal function in humans and differed significantly across animal species. Free-ranging brown bears showed a distinct regulation pattern with an increase in betaine (422%) and choline (18%) levels during hibernation, but exhibited undetectable levels of TMAO. Free-ranging brown bears had higher betaine, lower choline, and undetectable TMAO levels compared to captive brown bears. Endogenously produced betaine may protect bears and garden dormice during the vulnerable hibernating period. Carnivorous eating habits are linked to TMAO levels in the animal kingdom. Captivity may alter the microbiota and cause a subsequent increase of TMAO production. Since free-ranging bears seems to turn on a metabolic switch that shunts choline to generate betaine instead of TMAO, characterisation and understanding of such an adaptive switch could hold clues for novel treatment options in burden of lifestyle diseases, such as CKD.Thomas EbertJohanna PainerPeter BergmanAbdul Rashid QureshiSylvain GiroudGabrielle StalderKarolina KublickieneFrank GöritzSebastian VetterClaudia BieberOle FröbertJon M. ArnemoAndreas ZedrosserIrene RedtenbacherPaul G. ShielsRichard J. JohnsonPeter StenvinkelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thomas Ebert Johanna Painer Peter Bergman Abdul Rashid Qureshi Sylvain Giroud Gabrielle Stalder Karolina Kublickiene Frank Göritz Sebastian Vetter Claudia Bieber Ole Fröbert Jon M. Arnemo Andreas Zedrosser Irene Redtenbacher Paul G. Shiels Richard J. Johnson Peter Stenvinkel Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears
description	Abstract Experimental studies suggest involvement of trimethylamine N-oxide (TMAO) in the aetiology of cardiometabolic diseases and chronic kidney disease (CKD), in part via metabolism of ingested food. Using a comparative biomimetic approach, we have investigated circulating levels of the gut metabolites betaine, choline, and TMAO in human CKD, across animal species as well as during hibernation in two animal species. Betaine, choline, and TMAO levels were associated with renal function in humans and differed significantly across animal species. Free-ranging brown bears showed a distinct regulation pattern with an increase in betaine (422%) and choline (18%) levels during hibernation, but exhibited undetectable levels of TMAO. Free-ranging brown bears had higher betaine, lower choline, and undetectable TMAO levels compared to captive brown bears. Endogenously produced betaine may protect bears and garden dormice during the vulnerable hibernating period. Carnivorous eating habits are linked to TMAO levels in the animal kingdom. Captivity may alter the microbiota and cause a subsequent increase of TMAO production. Since free-ranging bears seems to turn on a metabolic switch that shunts choline to generate betaine instead of TMAO, characterisation and understanding of such an adaptive switch could hold clues for novel treatment options in burden of lifestyle diseases, such as CKD.
format	article
author	Thomas Ebert Johanna Painer Peter Bergman Abdul Rashid Qureshi Sylvain Giroud Gabrielle Stalder Karolina Kublickiene Frank Göritz Sebastian Vetter Claudia Bieber Ole Fröbert Jon M. Arnemo Andreas Zedrosser Irene Redtenbacher Paul G. Shiels Richard J. Johnson Peter Stenvinkel
author_facet	Thomas Ebert Johanna Painer Peter Bergman Abdul Rashid Qureshi Sylvain Giroud Gabrielle Stalder Karolina Kublickiene Frank Göritz Sebastian Vetter Claudia Bieber Ole Fröbert Jon M. Arnemo Andreas Zedrosser Irene Redtenbacher Paul G. Shiels Richard J. Johnson Peter Stenvinkel
author_sort	Thomas Ebert
title	Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears
title_short	Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears
title_full	Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears
title_fullStr	Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears
title_full_unstemmed	Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears
title_sort	insights in the regulation of trimetylamine n-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1ccf685f5a4d46ca94fdc9cd039dc816
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Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears

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