Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo

Adult mammalian cardiomyocytes are predominantly binucleated and unable to divide. Using single nuclear RNA-sequencing of cardiomyocytes from mouse and human failing and non-failing adult hearts, See et al. show that some cardiomyocytes respond to stress by dedifferentiation and cell cycle re-entry...

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Autores principales:	Kelvin See, Wilson L. W. Tan, Eng How Lim, Zenia Tiang, Li Ting Lee, Peter Y. Q. Li, Tuan D. A. Luu, Matthew Ackers-Johnson, Roger S. Foo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1cd271ae581b47ee8f939fe35db91009
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spelling	oai:doaj.org-article:1cd271ae581b47ee8f939fe35db910092021-12-02T13:57:44ZSingle cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo10.1038/s41467-017-00319-82041-1723https://doaj.org/article/1cd271ae581b47ee8f939fe35db910092017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00319-8https://doaj.org/toc/2041-1723Adult mammalian cardiomyocytes are predominantly binucleated and unable to divide. Using single nuclear RNA-sequencing of cardiomyocytes from mouse and human failing and non-failing adult hearts, See et al. show that some cardiomyocytes respond to stress by dedifferentiation and cell cycle re-entry regulated by lncRNAs.Kelvin SeeWilson L. W. TanEng How LimZenia TiangLi Ting LeePeter Y. Q. LiTuan D. A. LuuMatthew Ackers-JohnsonRoger S. FooNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kelvin See Wilson L. W. Tan Eng How Lim Zenia Tiang Li Ting Lee Peter Y. Q. Li Tuan D. A. Luu Matthew Ackers-Johnson Roger S. Foo Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo
description	Adult mammalian cardiomyocytes are predominantly binucleated and unable to divide. Using single nuclear RNA-sequencing of cardiomyocytes from mouse and human failing and non-failing adult hearts, See et al. show that some cardiomyocytes respond to stress by dedifferentiation and cell cycle re-entry regulated by lncRNAs.
format	article
author	Kelvin See Wilson L. W. Tan Eng How Lim Zenia Tiang Li Ting Lee Peter Y. Q. Li Tuan D. A. Luu Matthew Ackers-Johnson Roger S. Foo
author_facet	Kelvin See Wilson L. W. Tan Eng How Lim Zenia Tiang Li Ting Lee Peter Y. Q. Li Tuan D. A. Luu Matthew Ackers-Johnson Roger S. Foo
author_sort	Kelvin See
title	Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo
title_short	Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo
title_full	Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo
title_fullStr	Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo
title_full_unstemmed	Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo
title_sort	single cardiomyocyte nuclear transcriptomes reveal a lincrna-regulated de-differentiation and cell cycle stress-response in vivo
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1cd271ae581b47ee8f939fe35db91009
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Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo

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