NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1

NEK2 is a serine-threonine kinase overexpressed in a variety of human cancers. Here the authors show that NEK2 controls the stability of PD-L1 by preventing its proteasome-mediated degradation and that NEK2 targeting restores anti-tumor immune responses in preclinical models of pancreatic cancer.

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Autores principales:	Xiaozhen Zhang, Xing Huang, Jian Xu, Enliang Li, Mengyi Lao, Tianyu Tang, Gang Zhang, Chengxiang Guo, Xiaoyu Zhang, Wen Chen, Dipesh Kumar Yadav, Xueli Bai, Tingbo Liang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1cd631eb781b4095bfc716c8f7c76317
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spelling	oai:doaj.org-article:1cd631eb781b4095bfc716c8f7c763172021-12-02T16:30:11ZNEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L110.1038/s41467-021-24769-32041-1723https://doaj.org/article/1cd631eb781b4095bfc716c8f7c763172021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24769-3https://doaj.org/toc/2041-1723NEK2 is a serine-threonine kinase overexpressed in a variety of human cancers. Here the authors show that NEK2 controls the stability of PD-L1 by preventing its proteasome-mediated degradation and that NEK2 targeting restores anti-tumor immune responses in preclinical models of pancreatic cancer.Xiaozhen ZhangXing HuangJian XuEnliang LiMengyi LaoTianyu TangGang ZhangChengxiang GuoXiaoyu ZhangWen ChenDipesh Kumar YadavXueli BaiTingbo LiangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaozhen Zhang Xing Huang Jian Xu Enliang Li Mengyi Lao Tianyu Tang Gang Zhang Chengxiang Guo Xiaoyu Zhang Wen Chen Dipesh Kumar Yadav Xueli Bai Tingbo Liang NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1
description	NEK2 is a serine-threonine kinase overexpressed in a variety of human cancers. Here the authors show that NEK2 controls the stability of PD-L1 by preventing its proteasome-mediated degradation and that NEK2 targeting restores anti-tumor immune responses in preclinical models of pancreatic cancer.
format	article
author	Xiaozhen Zhang Xing Huang Jian Xu Enliang Li Mengyi Lao Tianyu Tang Gang Zhang Chengxiang Guo Xiaoyu Zhang Wen Chen Dipesh Kumar Yadav Xueli Bai Tingbo Liang
author_facet	Xiaozhen Zhang Xing Huang Jian Xu Enliang Li Mengyi Lao Tianyu Tang Gang Zhang Chengxiang Guo Xiaoyu Zhang Wen Chen Dipesh Kumar Yadav Xueli Bai Tingbo Liang
author_sort	Xiaozhen Zhang
title	NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1
title_short	NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1
title_full	NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1
title_fullStr	NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1
title_full_unstemmed	NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1
title_sort	nek2 inhibition triggers anti-pancreatic cancer immunity by targeting pd-l1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1cd631eb781b4095bfc716c8f7c76317
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NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1

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