An institutional review of tumour biology of breast cancer in young Nepalese women

Introduction: Breast cancers in less than 40 years of age group usually present with aggressive biology and has poor prognosis. The aim of this study was to see clinic-pathological and hormone receptors of breast cancers in young women and compare with less than 40 year age group. Methods: Prospec...

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Autores principales:	Bikash Nepal, Yogendra Singh, Prakash Sayami, Gita Sayami
Formato:	article
Lenguaje:	EN
Publicado:	Society of Surgeons of Nepal 2017
Materias:	Breast cancer ER HER2 neu PR Surgery RD1-811
Acceso en línea:	https://doaj.org/article/1cd65fb7319446d1bb946f6651fa4bfb
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spelling	oai:doaj.org-article:1cd65fb7319446d1bb946f6651fa4bfb2021-12-05T19:16:08ZAn institutional review of tumour biology of breast cancer in young Nepalese women10.3126/jssn.v18i2.185691815-39842392-4772https://doaj.org/article/1cd65fb7319446d1bb946f6651fa4bfb2017-11-01T00:00:00Zhttps://www.nepjol.info/index.php/JSSN/article/view/18569https://doaj.org/toc/1815-3984https://doaj.org/toc/2392-4772 Introduction: Breast cancers in less than 40 years of age group usually present with aggressive biology and has poor prognosis. The aim of this study was to see clinic-pathological and hormone receptors of breast cancers in young women and compare with less than 40 year age group. Methods: Prospective analysis of 97 breast cancer in patients less than 40 years out of total 373 patients (26%) over a period of 8 years (2007 Jan to 2014 Dec) was carried out at the Department of Surgery, Tribhuvan University Teaching Hospital, Kathmandu, Nepal. Result: Among the young women diagnosed with breast cancer, the mean age was 34.5±6.2 years. Mean tumour size was larger in younger women (5±2.5 vs 4.5±2.4 cm). Locally advanced disease was higher in younger patients (55% vs 47%). Lymphatic and vascular invasions were higher (63% vs 35% and 40% vs 25%). Grade II and III tumours was higher (56% vs 25%). ER, PR and HER2 positivity was detected in 46.9%, 48.9% and 28.9% respectively. Significant lower ER or PR expression (34.5% vs 54%) was seen in younger women, p=.002.Triple negative tumours (ER -ve, PR -ve and HER2 -ve) was proportionately higher in younger patients (23% vs 13.7%, p=.043). Conclusion: Young Nepali women presents one quarter of all female breast cancers, more frequently locally advanced with aggressive tumour biology like ER/PR negative and triple negative breast cancers. Journal of Society of Surgeons of Nepal, 2015; 18 (2), page: 16-19 Bikash NepalYogendra SinghPrakash SayamiGita SayamiSociety of Surgeons of NepalarticleBreast cancerERHER2 neuPRSurgeryRD1-811ENJournal of Society of Surgeons of Nepal, Vol 18, Iss 2 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Breast cancer ER HER2 neu PR Surgery RD1-811
spellingShingle	Breast cancer ER HER2 neu PR Surgery RD1-811 Bikash Nepal Yogendra Singh Prakash Sayami Gita Sayami An institutional review of tumour biology of breast cancer in young Nepalese women
description	Introduction: Breast cancers in less than 40 years of age group usually present with aggressive biology and has poor prognosis. The aim of this study was to see clinic-pathological and hormone receptors of breast cancers in young women and compare with less than 40 year age group. Methods: Prospective analysis of 97 breast cancer in patients less than 40 years out of total 373 patients (26%) over a period of 8 years (2007 Jan to 2014 Dec) was carried out at the Department of Surgery, Tribhuvan University Teaching Hospital, Kathmandu, Nepal. Result: Among the young women diagnosed with breast cancer, the mean age was 34.5±6.2 years. Mean tumour size was larger in younger women (5±2.5 vs 4.5±2.4 cm). Locally advanced disease was higher in younger patients (55% vs 47%). Lymphatic and vascular invasions were higher (63% vs 35% and 40% vs 25%). Grade II and III tumours was higher (56% vs 25%). ER, PR and HER2 positivity was detected in 46.9%, 48.9% and 28.9% respectively. Significant lower ER or PR expression (34.5% vs 54%) was seen in younger women, p=.002.Triple negative tumours (ER -ve, PR -ve and HER2 -ve) was proportionately higher in younger patients (23% vs 13.7%, p=.043). Conclusion: Young Nepali women presents one quarter of all female breast cancers, more frequently locally advanced with aggressive tumour biology like ER/PR negative and triple negative breast cancers. Journal of Society of Surgeons of Nepal, 2015; 18 (2), page: 16-19
format	article
author	Bikash Nepal Yogendra Singh Prakash Sayami Gita Sayami
author_facet	Bikash Nepal Yogendra Singh Prakash Sayami Gita Sayami
author_sort	Bikash Nepal
title	An institutional review of tumour biology of breast cancer in young Nepalese women
title_short	An institutional review of tumour biology of breast cancer in young Nepalese women
title_full	An institutional review of tumour biology of breast cancer in young Nepalese women
title_fullStr	An institutional review of tumour biology of breast cancer in young Nepalese women
title_full_unstemmed	An institutional review of tumour biology of breast cancer in young Nepalese women
title_sort	institutional review of tumour biology of breast cancer in young nepalese women
publisher	Society of Surgeons of Nepal
publishDate	2017
url	https://doaj.org/article/1cd65fb7319446d1bb946f6651fa4bfb
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An institutional review of tumour biology of breast cancer in young Nepalese women

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