High diversity of hepatitis B virus genotypes in Panamanian blood donors: a molecular analysis of new variants.

Hepatitis B Virus (HBV) is an infectious agent that causes more than half of the cases of liver disease and cancer in the world. Globally there are around 250 million people chronically infected with this virus. Despite 16% of the cases of liver disease in Central America are caused by HBV, the info...

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Autores principales:	Alexander A Martínez, Yamitzel Y Zaldivar, CSS-NAT Group, Zoila De Castillo, Alma Y Ortiz, Yaxelis Mendoza, Juan Cristina, Juan M Pascale
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1cd77394f9314715ba4bdfd609c320fb
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spelling	oai:doaj.org-article:1cd77394f9314715ba4bdfd609c320fb2021-11-25T06:05:57ZHigh diversity of hepatitis B virus genotypes in Panamanian blood donors: a molecular analysis of new variants.1932-620310.1371/journal.pone.0103545https://doaj.org/article/1cd77394f9314715ba4bdfd609c320fb2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25093674/?tool=EBIhttps://doaj.org/toc/1932-6203Hepatitis B Virus (HBV) is an infectious agent that causes more than half of the cases of liver disease and cancer in the world. Globally there are around 250 million people chronically infected with this virus. Despite 16% of the cases of liver disease in Central America are caused by HBV, the information regarding its genetic diversity, genotypes and circulation is scarce. The purpose of this study was to evaluate the genetic variability of the HBV genotypes from HBV-DNA positive samples obtained from screening blood donors at the Social Security System of Panama and to estimate its possible origin. From 59,696 blood donors tested for HBV infection during 2010-2012, there were 74 HBV-DNA positive subjects. Analysis of the partial PreS2-S region of 27 sequences shows that 21% of the infections were caused by genotype A, 3% by genotype D and 76% by genotype F. In addition, we were able to confirm circulation of six sub-genotypes A1, A2, A3, D4, F3, F1 and a proposed new sub-genotype denominated F5pan. We found a confinement of sub-genotypes F1 and F5pan to the western area of Panama. The tMRCA analysis suggests a simultaneous circulation of previously described sub-genotypes rather than recent introductions of the Panamanian sub-genotypes in the country. Moreover, these results highlight the need of more intensive research of the HBV strains circulating in the region at the molecular level. In conclusion, Panama has a high HBV genotype diversity that includes a new proposed sub-genotype, an elevated number of PreCore-Core mutations, and confinement of these variants in a specific geographical location.Alexander A MartínezYamitzel Y ZaldivarCSS-NAT GroupZoila De CastilloAlma Y OrtizYaxelis MendozaJuan CristinaJuan M PascalePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e103545 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexander A Martínez Yamitzel Y Zaldivar CSS-NAT Group Zoila De Castillo Alma Y Ortiz Yaxelis Mendoza Juan Cristina Juan M Pascale High diversity of hepatitis B virus genotypes in Panamanian blood donors: a molecular analysis of new variants.
description	Hepatitis B Virus (HBV) is an infectious agent that causes more than half of the cases of liver disease and cancer in the world. Globally there are around 250 million people chronically infected with this virus. Despite 16% of the cases of liver disease in Central America are caused by HBV, the information regarding its genetic diversity, genotypes and circulation is scarce. The purpose of this study was to evaluate the genetic variability of the HBV genotypes from HBV-DNA positive samples obtained from screening blood donors at the Social Security System of Panama and to estimate its possible origin. From 59,696 blood donors tested for HBV infection during 2010-2012, there were 74 HBV-DNA positive subjects. Analysis of the partial PreS2-S region of 27 sequences shows that 21% of the infections were caused by genotype A, 3% by genotype D and 76% by genotype F. In addition, we were able to confirm circulation of six sub-genotypes A1, A2, A3, D4, F3, F1 and a proposed new sub-genotype denominated F5pan. We found a confinement of sub-genotypes F1 and F5pan to the western area of Panama. The tMRCA analysis suggests a simultaneous circulation of previously described sub-genotypes rather than recent introductions of the Panamanian sub-genotypes in the country. Moreover, these results highlight the need of more intensive research of the HBV strains circulating in the region at the molecular level. In conclusion, Panama has a high HBV genotype diversity that includes a new proposed sub-genotype, an elevated number of PreCore-Core mutations, and confinement of these variants in a specific geographical location.
format	article
author	Alexander A Martínez Yamitzel Y Zaldivar CSS-NAT Group Zoila De Castillo Alma Y Ortiz Yaxelis Mendoza Juan Cristina Juan M Pascale
author_facet	Alexander A Martínez Yamitzel Y Zaldivar CSS-NAT Group Zoila De Castillo Alma Y Ortiz Yaxelis Mendoza Juan Cristina Juan M Pascale
author_sort	Alexander A Martínez
title	High diversity of hepatitis B virus genotypes in Panamanian blood donors: a molecular analysis of new variants.
title_short	High diversity of hepatitis B virus genotypes in Panamanian blood donors: a molecular analysis of new variants.
title_full	High diversity of hepatitis B virus genotypes in Panamanian blood donors: a molecular analysis of new variants.
title_fullStr	High diversity of hepatitis B virus genotypes in Panamanian blood donors: a molecular analysis of new variants.
title_full_unstemmed	High diversity of hepatitis B virus genotypes in Panamanian blood donors: a molecular analysis of new variants.
title_sort	high diversity of hepatitis b virus genotypes in panamanian blood donors: a molecular analysis of new variants.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/1cd77394f9314715ba4bdfd609c320fb
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High diversity of hepatitis B virus genotypes in Panamanian blood donors: a molecular analysis of new variants.

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