Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds

Human pluripotent stem cell derived neurons have the potential for cell replacement therapy for brain injury and disease but problems on transplantation need to be overcome. Here, the authors use a microtopographic scaffold to graft neurons into both hippocampal organoids and the mouse brain striatu...

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Autores principales:	Aaron L. Carlson, Neal K. Bennett, Nicola L. Francis, Apoorva Halikere, Stephen Clarke, Jennifer C. Moore, Ronald P. Hart, Kenneth Paradiso, Marius Wernig, Joachim Kohn, Zhiping P. Pang, Prabhas V. Moghe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1cdbd92bc9c24daca3285c1be2d05c12
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spelling	oai:doaj.org-article:1cdbd92bc9c24daca3285c1be2d05c122021-12-02T16:49:59ZGeneration and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds10.1038/ncomms108622041-1723https://doaj.org/article/1cdbd92bc9c24daca3285c1be2d05c122016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10862https://doaj.org/toc/2041-1723Human pluripotent stem cell derived neurons have the potential for cell replacement therapy for brain injury and disease but problems on transplantation need to be overcome. Here, the authors use a microtopographic scaffold to graft neurons into both hippocampal organoids and the mouse brain striatum.Aaron L. CarlsonNeal K. BennettNicola L. FrancisApoorva HalikereStephen ClarkeJennifer C. MooreRonald P. HartKenneth ParadisoMarius WernigJoachim KohnZhiping P. PangPrabhas V. MogheNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aaron L. Carlson Neal K. Bennett Nicola L. Francis Apoorva Halikere Stephen Clarke Jennifer C. Moore Ronald P. Hart Kenneth Paradiso Marius Wernig Joachim Kohn Zhiping P. Pang Prabhas V. Moghe Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds
description	Human pluripotent stem cell derived neurons have the potential for cell replacement therapy for brain injury and disease but problems on transplantation need to be overcome. Here, the authors use a microtopographic scaffold to graft neurons into both hippocampal organoids and the mouse brain striatum.
format	article
author	Aaron L. Carlson Neal K. Bennett Nicola L. Francis Apoorva Halikere Stephen Clarke Jennifer C. Moore Ronald P. Hart Kenneth Paradiso Marius Wernig Joachim Kohn Zhiping P. Pang Prabhas V. Moghe
author_facet	Aaron L. Carlson Neal K. Bennett Nicola L. Francis Apoorva Halikere Stephen Clarke Jennifer C. Moore Ronald P. Hart Kenneth Paradiso Marius Wernig Joachim Kohn Zhiping P. Pang Prabhas V. Moghe
author_sort	Aaron L. Carlson
title	Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds
title_short	Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds
title_full	Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds
title_fullStr	Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds
title_full_unstemmed	Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds
title_sort	generation and transplantation of reprogrammed human neurons in the brain using 3d microtopographic scaffolds
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1cdbd92bc9c24daca3285c1be2d05c12
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Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds

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