Analysis of SteraMist ionized hydrogen peroxide technology in the sterilization of N95 respirators and other PPE

Abstract The COVID-19 pandemic has led to widespread shortages of personal protective equipment (PPE) for healthcare workers, including of N95 masks (filtering facepiece respirators; FFRs). These masks are intended for single use but their sterilization and subsequent reuse has the potential to subs...

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Autores principales:	Avilash K. Cramer, Deborah Plana, Helen Yang, Mary M. Carmack, Enze Tian, Michael S. Sinha, David Krikorian, David Turner, Jinhan Mo, Ju Li, Rajiv Gupta, Heather Manning, Florence T. Bourgeois, Sherry H. Yu, Peter K. Sorger, Nicole R. LeBoeuf
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1cdeeeb3fc8c40629d0c845befb258d6
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spelling	oai:doaj.org-article:1cdeeeb3fc8c40629d0c845befb258d62021-12-02T10:49:16ZAnalysis of SteraMist ionized hydrogen peroxide technology in the sterilization of N95 respirators and other PPE10.1038/s41598-021-81365-72045-2322https://doaj.org/article/1cdeeeb3fc8c40629d0c845befb258d62021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81365-7https://doaj.org/toc/2045-2322Abstract The COVID-19 pandemic has led to widespread shortages of personal protective equipment (PPE) for healthcare workers, including of N95 masks (filtering facepiece respirators; FFRs). These masks are intended for single use but their sterilization and subsequent reuse has the potential to substantially mitigate shortages. Here we investigate PPE sterilization using ionized hydrogen peroxide (iHP), generated by SteraMist equipment (TOMI; Frederick, MD), in a sealed environment chamber. The efficacy of sterilization by iHP was assessed using bacterial spores in biological indicator assemblies. After one or more iHP treatments, five models of N95 masks from three manufacturers were assessed for retention of function based on their ability to form an airtight seal (measured using a quantitative fit test) and filter aerosolized particles. Filtration testing was performed at a university lab and at a National Institute for Occupational Safety and Health (NIOSH) pre-certification laboratory. The data demonstrate that N95 masks sterilized using SteraMist iHP technology retain filtration efficiency up to ten cycles, the maximum number tested to date. A typical iHP environment chamber with a volume of ~ 80 m3 can treat ~ 7000 masks and other items (e.g. other PPE, iPADs), making this an effective approach for a busy medical center.Avilash K. CramerDeborah PlanaHelen YangMary M. CarmackEnze TianMichael S. SinhaDavid KrikorianDavid TurnerJinhan MoJu LiRajiv GuptaHeather ManningFlorence T. BourgeoisSherry H. YuPeter K. SorgerNicole R. LeBoeufNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Avilash K. Cramer Deborah Plana Helen Yang Mary M. Carmack Enze Tian Michael S. Sinha David Krikorian David Turner Jinhan Mo Ju Li Rajiv Gupta Heather Manning Florence T. Bourgeois Sherry H. Yu Peter K. Sorger Nicole R. LeBoeuf Analysis of SteraMist ionized hydrogen peroxide technology in the sterilization of N95 respirators and other PPE
description	Abstract The COVID-19 pandemic has led to widespread shortages of personal protective equipment (PPE) for healthcare workers, including of N95 masks (filtering facepiece respirators; FFRs). These masks are intended for single use but their sterilization and subsequent reuse has the potential to substantially mitigate shortages. Here we investigate PPE sterilization using ionized hydrogen peroxide (iHP), generated by SteraMist equipment (TOMI; Frederick, MD), in a sealed environment chamber. The efficacy of sterilization by iHP was assessed using bacterial spores in biological indicator assemblies. After one or more iHP treatments, five models of N95 masks from three manufacturers were assessed for retention of function based on their ability to form an airtight seal (measured using a quantitative fit test) and filter aerosolized particles. Filtration testing was performed at a university lab and at a National Institute for Occupational Safety and Health (NIOSH) pre-certification laboratory. The data demonstrate that N95 masks sterilized using SteraMist iHP technology retain filtration efficiency up to ten cycles, the maximum number tested to date. A typical iHP environment chamber with a volume of ~ 80 m3 can treat ~ 7000 masks and other items (e.g. other PPE, iPADs), making this an effective approach for a busy medical center.
format	article
author	Avilash K. Cramer Deborah Plana Helen Yang Mary M. Carmack Enze Tian Michael S. Sinha David Krikorian David Turner Jinhan Mo Ju Li Rajiv Gupta Heather Manning Florence T. Bourgeois Sherry H. Yu Peter K. Sorger Nicole R. LeBoeuf
author_facet	Avilash K. Cramer Deborah Plana Helen Yang Mary M. Carmack Enze Tian Michael S. Sinha David Krikorian David Turner Jinhan Mo Ju Li Rajiv Gupta Heather Manning Florence T. Bourgeois Sherry H. Yu Peter K. Sorger Nicole R. LeBoeuf
author_sort	Avilash K. Cramer
title	Analysis of SteraMist ionized hydrogen peroxide technology in the sterilization of N95 respirators and other PPE
title_short	Analysis of SteraMist ionized hydrogen peroxide technology in the sterilization of N95 respirators and other PPE
title_full	Analysis of SteraMist ionized hydrogen peroxide technology in the sterilization of N95 respirators and other PPE
title_fullStr	Analysis of SteraMist ionized hydrogen peroxide technology in the sterilization of N95 respirators and other PPE
title_full_unstemmed	Analysis of SteraMist ionized hydrogen peroxide technology in the sterilization of N95 respirators and other PPE
title_sort	analysis of steramist ionized hydrogen peroxide technology in the sterilization of n95 respirators and other ppe
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1cdeeeb3fc8c40629d0c845befb258d6
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Analysis of SteraMist ionized hydrogen peroxide technology in the sterilization of N95 respirators and other PPE

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