Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen

Amir Hadanny,1,2 Amit Maliar,1 Gregory Fishlev,1 Yair Bechor,1 Jacob Bergan,1 Mony Friedman,1 Isaac Avni,2,3 Shai Efrati1,2,4,5 1Sagol Center for Hyperbaric Medicine and Research, Assaf Harofeh Medical Center, Zerifin, Israel; 2Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel; 3Opt...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hadanny A, Maliar A, Fishlev G, Bechor Y, Bergan J, Friedman M, Avni I, Efrati S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	HBOT Hyperbaric Oxygen Central Retinal Artery Occlusion Cherry red spot CRAO retinal ischemia Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/1ce0223062d54984a5735eaef9520bae
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1ce0223062d54984a5735eaef9520bae
record_format	dspace
spelling	oai:doaj.org-article:1ce0223062d54984a5735eaef9520bae2021-12-02T04:06:10ZReversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen1177-5483https://doaj.org/article/1ce0223062d54984a5735eaef9520bae2016-12-01T00:00:00Zhttps://www.dovepress.com/reversibility-of-retinal-ischemia-due-to-central-retinal-artery-occlus-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Amir Hadanny,1,2 Amit Maliar,1 Gregory Fishlev,1 Yair Bechor,1 Jacob Bergan,1 Mony Friedman,1 Isaac Avni,2,3 Shai Efrati1,2,4,5 1Sagol Center for Hyperbaric Medicine and Research, Assaf Harofeh Medical Center, Zerifin, Israel; 2Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel; 3Opthalmology Department, Assaf Harofeh Medical Center, Zeirifin, Israel; 4Research and Development Unit, Assaf Harofeh Medical Center, Zerifin, Israel; 5Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel Purpose: Ischemic retinal damage can be reversed by hyperbaric oxygen therapy (HBOT) as long as irreversible infarction damage has not developed. However, the time window till irreversible damage develops is still unknown. The study aim was to evaluate the effect of HBOT and determine possible markers for irreversible retinal damage.Materials and methods: Retrospective analysis of 225 patients treated with HBOT for central retinal artery occlusion (CRAO) in 1999–2015. One hundred and twenty-eight patients fulfilled inclusion/exclusion criteria: age >18 years, symptoms <20 hours, and best-corrected visual acuity (BCVA) <0.5 logMAR.Results: Time delay from symptoms to treatment was 7.8±3.8 hours. The BCVA was significantly improved after HBOT, from 2.14±0.50 to 1.61±0.78 (P<0.0001). The proportion of patients with clinically meaningful visual improvement was significantly higher in patients without cherry-red spot (CRS) compared to patients with CRS at presentation (86.0% vs 57.6%, P<0.0001). The percentage of patients with final BCVA better than 1.0 was also significantly higher in patients without CRS vs patients with CRS at presentation (61.0% vs 7.1%, P<0.0001). There was no correlation between CRS and the time from symptoms. HBOT was found to be safe, and only 5.5% of patients had minor, reversible, adverse events.Conclusion: HBOT is an effective treatment for non-arteritic CRAO as long as CRS has not formed. The fundus findings, rather than the time delay, should be used as a marker for irreversible damage. Keywords: HBOT, hyperbaric oxygen, central retinal artery occlusion, cherry-red spot, CRAO, retinal ischemiaHadanny AMaliar AFishlev GBechor YBergan JFriedman MAvni IEfrati SDove Medical PressarticleHBOTHyperbaric OxygenCentral Retinal Artery OcclusionCherry red spotCRAOretinal ischemiaOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 115-125 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	HBOT Hyperbaric Oxygen Central Retinal Artery Occlusion Cherry red spot CRAO retinal ischemia Ophthalmology RE1-994
spellingShingle	HBOT Hyperbaric Oxygen Central Retinal Artery Occlusion Cherry red spot CRAO retinal ischemia Ophthalmology RE1-994 Hadanny A Maliar A Fishlev G Bechor Y Bergan J Friedman M Avni I Efrati S Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen
description	Amir Hadanny,1,2 Amit Maliar,1 Gregory Fishlev,1 Yair Bechor,1 Jacob Bergan,1 Mony Friedman,1 Isaac Avni,2,3 Shai Efrati1,2,4,5 1Sagol Center for Hyperbaric Medicine and Research, Assaf Harofeh Medical Center, Zerifin, Israel; 2Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel; 3Opthalmology Department, Assaf Harofeh Medical Center, Zeirifin, Israel; 4Research and Development Unit, Assaf Harofeh Medical Center, Zerifin, Israel; 5Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel Purpose: Ischemic retinal damage can be reversed by hyperbaric oxygen therapy (HBOT) as long as irreversible infarction damage has not developed. However, the time window till irreversible damage develops is still unknown. The study aim was to evaluate the effect of HBOT and determine possible markers for irreversible retinal damage.Materials and methods: Retrospective analysis of 225 patients treated with HBOT for central retinal artery occlusion (CRAO) in 1999–2015. One hundred and twenty-eight patients fulfilled inclusion/exclusion criteria: age >18 years, symptoms <20 hours, and best-corrected visual acuity (BCVA) <0.5 logMAR.Results: Time delay from symptoms to treatment was 7.8±3.8 hours. The BCVA was significantly improved after HBOT, from 2.14±0.50 to 1.61±0.78 (P<0.0001). The proportion of patients with clinically meaningful visual improvement was significantly higher in patients without cherry-red spot (CRS) compared to patients with CRS at presentation (86.0% vs 57.6%, P<0.0001). The percentage of patients with final BCVA better than 1.0 was also significantly higher in patients without CRS vs patients with CRS at presentation (61.0% vs 7.1%, P<0.0001). There was no correlation between CRS and the time from symptoms. HBOT was found to be safe, and only 5.5% of patients had minor, reversible, adverse events.Conclusion: HBOT is an effective treatment for non-arteritic CRAO as long as CRS has not formed. The fundus findings, rather than the time delay, should be used as a marker for irreversible damage. Keywords: HBOT, hyperbaric oxygen, central retinal artery occlusion, cherry-red spot, CRAO, retinal ischemia
format	article
author	Hadanny A Maliar A Fishlev G Bechor Y Bergan J Friedman M Avni I Efrati S
author_facet	Hadanny A Maliar A Fishlev G Bechor Y Bergan J Friedman M Avni I Efrati S
author_sort	Hadanny A
title	Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen
title_short	Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen
title_full	Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen
title_fullStr	Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen
title_full_unstemmed	Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen
title_sort	reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/1ce0223062d54984a5735eaef9520bae
work_keys_str_mv	AT hadannya reversibilityofretinalischemiaduetocentralretinalarteryocclusionbyhyperbaricoxygen AT maliara reversibilityofretinalischemiaduetocentralretinalarteryocclusionbyhyperbaricoxygen AT fishlevg reversibilityofretinalischemiaduetocentralretinalarteryocclusionbyhyperbaricoxygen AT bechory reversibilityofretinalischemiaduetocentralretinalarteryocclusionbyhyperbaricoxygen AT berganj reversibilityofretinalischemiaduetocentralretinalarteryocclusionbyhyperbaricoxygen AT friedmanm reversibilityofretinalischemiaduetocentralretinalarteryocclusionbyhyperbaricoxygen AT avnii reversibilityofretinalischemiaduetocentralretinalarteryocclusionbyhyperbaricoxygen AT efratis reversibilityofretinalischemiaduetocentralretinalarteryocclusionbyhyperbaricoxygen
_version_	1718401416955953152

Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen

Ejemplares similares