Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis

Spondyloarthritis is an inflammatory disease with Th17 cells implicated in the pathogenesis. Here the authors show that patients with spondyloarthritis have increased numbers of GM-CSF-secreting blood and synovial lymphocytes, Th17 or not, that carry a unique transcriptional profile including enhanc...

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Autores principales:	M. H. Al-Mossawi, L. Chen, H. Fang, A. Ridley, J. de Wit, N. Yager, A. Hammitzsch, I. Pulyakhina, B. P. Fairfax, D. Simone, Yao Yi, S. Bandyopadhyay, K. Doig, R Gundle, B. Kendrick, F. Powrie, J. C. Knight, P. Bowness
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1ce207c6c774466e8f0f97749494b098
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spelling	oai:doaj.org-article:1ce207c6c774466e8f0f97749494b0982021-12-02T14:40:57ZUnique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis10.1038/s41467-017-01771-22041-1723https://doaj.org/article/1ce207c6c774466e8f0f97749494b0982017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01771-2https://doaj.org/toc/2041-1723Spondyloarthritis is an inflammatory disease with Th17 cells implicated in the pathogenesis. Here the authors show that patients with spondyloarthritis have increased numbers of GM-CSF-secreting blood and synovial lymphocytes, Th17 or not, that carry a unique transcriptional profile including enhanced GPR65 expression.M. H. Al-MossawiL. ChenH. FangA. RidleyJ. de WitN. YagerA. HammitzschI. PulyakhinaB. P. FairfaxD. SimoneYao YiS. BandyopadhyayK. DoigR GundleB. KendrickF. PowrieJ. C. KnightP. BownessNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q M. H. Al-Mossawi L. Chen H. Fang A. Ridley J. de Wit N. Yager A. Hammitzsch I. Pulyakhina B. P. Fairfax D. Simone Yao Yi S. Bandyopadhyay K. Doig R Gundle B. Kendrick F. Powrie J. C. Knight P. Bowness Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis
description	Spondyloarthritis is an inflammatory disease with Th17 cells implicated in the pathogenesis. Here the authors show that patients with spondyloarthritis have increased numbers of GM-CSF-secreting blood and synovial lymphocytes, Th17 or not, that carry a unique transcriptional profile including enhanced GPR65 expression.
format	article
author	M. H. Al-Mossawi L. Chen H. Fang A. Ridley J. de Wit N. Yager A. Hammitzsch I. Pulyakhina B. P. Fairfax D. Simone Yao Yi S. Bandyopadhyay K. Doig R Gundle B. Kendrick F. Powrie J. C. Knight P. Bowness
author_facet	M. H. Al-Mossawi L. Chen H. Fang A. Ridley J. de Wit N. Yager A. Hammitzsch I. Pulyakhina B. P. Fairfax D. Simone Yao Yi S. Bandyopadhyay K. Doig R Gundle B. Kendrick F. Powrie J. C. Knight P. Bowness
author_sort	M. H. Al-Mossawi
title	Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis
title_short	Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis
title_full	Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis
title_fullStr	Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis
title_full_unstemmed	Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis
title_sort	unique transcriptome signatures and gm-csf expression in lymphocytes from patients with spondyloarthritis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1ce207c6c774466e8f0f97749494b098
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Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis

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