Oxidative Stress and Cardiovascular Risk in Type 1 Diabetes Mellitus: Insights From the <styled-content style="fixed-case">DCCT</styled-content>/<styled-content style="fixed-case">EDIC</styled-content> Study

BackgroundHyperglycemia leading to increased oxidative stress is implicated in the increased risk for the development of macrovascular and microvascular complications in patients with type 1 diabetes mellitus. Methods and ResultsA random subcohort of 349 participants was selected from the DCCT/EDIC...

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Autores principales:	W.H. Wilson Tang, Paula McGee, John M. Lachin, Daniel Y. Li, Byron Hoogwerf, Stanley L. Hazen
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2018
Materias:	diabetes mellitus F2Isoprostane free radical paraoxonase Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/1ce84211d9aa463dbcae39d3029dfd2f
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spelling	oai:doaj.org-article:1ce84211d9aa463dbcae39d3029dfd2f2021-11-12T17:01:54ZOxidative Stress and Cardiovascular Risk in Type 1 Diabetes Mellitus: Insights From the <styled-content style="fixed-case">DCCT</styled-content>/<styled-content style="fixed-case">EDIC</styled-content> Study10.1161/JAHA.117.0083682047-9980https://doaj.org/article/1ce84211d9aa463dbcae39d3029dfd2f2018-05-01T00:00:00Zhttps://www.ahajournals.org/doi/10.1161/JAHA.117.008368https://doaj.org/toc/2047-9980BackgroundHyperglycemia leading to increased oxidative stress is implicated in the increased risk for the development of macrovascular and microvascular complications in patients with type 1 diabetes mellitus. Methods and ResultsA random subcohort of 349 participants was selected from the DCCT/EDIC (Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications) cohort. This included 320 controls and 29 cardiovascular disease cases that were augmented with 98 additional known cases to yield a case cohort of 447 participants (320 controls, 127 cases). Biosamples from DCCT baseline, year 1, and closeout of DCCT, and 1 to 2 years post‐DCCT (EDIC years 1 and 2) were measured for markers of oxidative stress, including plasma myeloperoxidase, paraoxonase activity, urinary F2α isoprostanes, and its metabolite, 2,3 dinor‐8 iso prostaglandin F2α. Following adjustment for glycated hemoblobin and weighting the observations inversely proportional to the sampling selection probabilities, higher paraoxonase activity, reflective of antioxidant activity, and 2,3 dinor‐8 iso prostaglandin F2α, an oxidative marker, were significantly associated with lower risk of cardiovascular disease (−4.5% risk for 10% higher paraoxonase, P<0.003; −5.3% risk for 10% higher 2,3 dinor‐8 iso prostaglandin F2α, P=0.0092). In contrast, the oxidative markers myeloperoxidase and F2α isoprostanes were not significantly associated with cardiovascular disease after adjustment for glycated hemoblobin. There were no significant differences between DCCT intensive and conventional treatment groups in the change in all biomarkers across time segments. ConclusionsHeightened antioxidant activity (rather than diminished oxidative stress markers) is associated with lower cardiovascular disease risk in type 1 diabetes mellitus, but these biomarkers did not change over time with intensification of glycemic control. Clinical Trial RegistrationURL: https://www.clinicaltrials.gov. Unique identifiers: NCT00360815 and NCT00360893.W.H. Wilson TangPaula McGeeJohn M. LachinDaniel Y. LiByron HoogwerfStanley L. HazenWileyarticlediabetes mellitusF2Isoprostanefree radicalparaoxonaseDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus F2Isoprostane free radical paraoxonase Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	diabetes mellitus F2Isoprostane free radical paraoxonase Diseases of the circulatory (Cardiovascular) system RC666-701 W.H. Wilson Tang Paula McGee John M. Lachin Daniel Y. Li Byron Hoogwerf Stanley L. Hazen Oxidative Stress and Cardiovascular Risk in Type 1 Diabetes Mellitus: Insights From the <styled-content style="fixed-case">DCCT</styled-content>/<styled-content style="fixed-case">EDIC</styled-content> Study
description	BackgroundHyperglycemia leading to increased oxidative stress is implicated in the increased risk for the development of macrovascular and microvascular complications in patients with type 1 diabetes mellitus. Methods and ResultsA random subcohort of 349 participants was selected from the DCCT/EDIC (Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications) cohort. This included 320 controls and 29 cardiovascular disease cases that were augmented with 98 additional known cases to yield a case cohort of 447 participants (320 controls, 127 cases). Biosamples from DCCT baseline, year 1, and closeout of DCCT, and 1 to 2 years post‐DCCT (EDIC years 1 and 2) were measured for markers of oxidative stress, including plasma myeloperoxidase, paraoxonase activity, urinary F2α isoprostanes, and its metabolite, 2,3 dinor‐8 iso prostaglandin F2α. Following adjustment for glycated hemoblobin and weighting the observations inversely proportional to the sampling selection probabilities, higher paraoxonase activity, reflective of antioxidant activity, and 2,3 dinor‐8 iso prostaglandin F2α, an oxidative marker, were significantly associated with lower risk of cardiovascular disease (−4.5% risk for 10% higher paraoxonase, P<0.003; −5.3% risk for 10% higher 2,3 dinor‐8 iso prostaglandin F2α, P=0.0092). In contrast, the oxidative markers myeloperoxidase and F2α isoprostanes were not significantly associated with cardiovascular disease after adjustment for glycated hemoblobin. There were no significant differences between DCCT intensive and conventional treatment groups in the change in all biomarkers across time segments. ConclusionsHeightened antioxidant activity (rather than diminished oxidative stress markers) is associated with lower cardiovascular disease risk in type 1 diabetes mellitus, but these biomarkers did not change over time with intensification of glycemic control. Clinical Trial RegistrationURL: https://www.clinicaltrials.gov. Unique identifiers: NCT00360815 and NCT00360893.
format	article
author	W.H. Wilson Tang Paula McGee John M. Lachin Daniel Y. Li Byron Hoogwerf Stanley L. Hazen
author_facet	W.H. Wilson Tang Paula McGee John M. Lachin Daniel Y. Li Byron Hoogwerf Stanley L. Hazen
author_sort	W.H. Wilson Tang
title	Oxidative Stress and Cardiovascular Risk in Type 1 Diabetes Mellitus: Insights From the <styled-content style="fixed-case">DCCT</styled-content>/<styled-content style="fixed-case">EDIC</styled-content> Study
title_short	Oxidative Stress and Cardiovascular Risk in Type 1 Diabetes Mellitus: Insights From the <styled-content style="fixed-case">DCCT</styled-content>/<styled-content style="fixed-case">EDIC</styled-content> Study
title_full	Oxidative Stress and Cardiovascular Risk in Type 1 Diabetes Mellitus: Insights From the <styled-content style="fixed-case">DCCT</styled-content>/<styled-content style="fixed-case">EDIC</styled-content> Study
title_fullStr	Oxidative Stress and Cardiovascular Risk in Type 1 Diabetes Mellitus: Insights From the <styled-content style="fixed-case">DCCT</styled-content>/<styled-content style="fixed-case">EDIC</styled-content> Study
title_full_unstemmed	Oxidative Stress and Cardiovascular Risk in Type 1 Diabetes Mellitus: Insights From the <styled-content style="fixed-case">DCCT</styled-content>/<styled-content style="fixed-case">EDIC</styled-content> Study
title_sort	oxidative stress and cardiovascular risk in type 1 diabetes mellitus: insights from the <styled-content style="fixed-case">dcct</styled-content>/<styled-content style="fixed-case">edic</styled-content> study
publisher	Wiley
publishDate	2018
url	https://doaj.org/article/1ce84211d9aa463dbcae39d3029dfd2f
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Oxidative Stress and Cardiovascular Risk in Type 1 Diabetes Mellitus: Insights From the <styled-content style="fixed-case">DCCT</styled-content>/<styled-content style="fixed-case">EDIC</styled-content> Study

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