The modulation of neural insular activity by a brain computer interface differentially affects pain discrimination

Abstract The experience of pain is generated by activations throughout a complex pain network with the insular cortex as a central processing area. The state of ongoing oscillatory activity can influence subsequent processing throughout this network. In particular the ongoing theta-band power can be...

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Autores principales:	Philipp Taesler, Michael Rose
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1cea1d8e65934496a975d26d430fb090
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spelling	oai:doaj.org-article:1cea1d8e65934496a975d26d430fb0902021-12-02T14:49:34ZThe modulation of neural insular activity by a brain computer interface differentially affects pain discrimination10.1038/s41598-021-89206-32045-2322https://doaj.org/article/1cea1d8e65934496a975d26d430fb0902021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89206-3https://doaj.org/toc/2045-2322Abstract The experience of pain is generated by activations throughout a complex pain network with the insular cortex as a central processing area. The state of ongoing oscillatory activity can influence subsequent processing throughout this network. In particular the ongoing theta-band power can be relevant for later pain processing, however a direct functional relation to post-stimulus processing or behaviour is missing. Here, we used a non-invasive brain–computer interface to either increase or decrease ongoing theta-band power originating in the insular cortex. Our results show a differential modulation of oscillatory power and even more important a transfer to independently measured pain processing and sensation. Pain evoked neural power and subjective pain discrimination were differentially affected by the induced modulations of the oscillatory state. The results demonstrate a functional relevance of insular based theta-band oscillatory states for the processing and subjective discrimination of nociceptive stimuli and offer the perspective for clinical applications.Philipp TaeslerMichael RoseNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Philipp Taesler Michael Rose The modulation of neural insular activity by a brain computer interface differentially affects pain discrimination
description	Abstract The experience of pain is generated by activations throughout a complex pain network with the insular cortex as a central processing area. The state of ongoing oscillatory activity can influence subsequent processing throughout this network. In particular the ongoing theta-band power can be relevant for later pain processing, however a direct functional relation to post-stimulus processing or behaviour is missing. Here, we used a non-invasive brain–computer interface to either increase or decrease ongoing theta-band power originating in the insular cortex. Our results show a differential modulation of oscillatory power and even more important a transfer to independently measured pain processing and sensation. Pain evoked neural power and subjective pain discrimination were differentially affected by the induced modulations of the oscillatory state. The results demonstrate a functional relevance of insular based theta-band oscillatory states for the processing and subjective discrimination of nociceptive stimuli and offer the perspective for clinical applications.
format	article
author	Philipp Taesler Michael Rose
author_facet	Philipp Taesler Michael Rose
author_sort	Philipp Taesler
title	The modulation of neural insular activity by a brain computer interface differentially affects pain discrimination
title_short	The modulation of neural insular activity by a brain computer interface differentially affects pain discrimination
title_full	The modulation of neural insular activity by a brain computer interface differentially affects pain discrimination
title_fullStr	The modulation of neural insular activity by a brain computer interface differentially affects pain discrimination
title_full_unstemmed	The modulation of neural insular activity by a brain computer interface differentially affects pain discrimination
title_sort	modulation of neural insular activity by a brain computer interface differentially affects pain discrimination
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1cea1d8e65934496a975d26d430fb090
work_keys_str_mv	AT philipptaesler themodulationofneuralinsularactivitybyabraincomputerinterfacedifferentiallyaffectspaindiscrimination AT michaelrose themodulationofneuralinsularactivitybyabraincomputerinterfacedifferentiallyaffectspaindiscrimination AT philipptaesler modulationofneuralinsularactivitybyabraincomputerinterfacedifferentiallyaffectspaindiscrimination AT michaelrose modulationofneuralinsularactivitybyabraincomputerinterfacedifferentiallyaffectspaindiscrimination
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The modulation of neural insular activity by a brain computer interface differentially affects pain discrimination

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