The potential antiepileptogenic effect of neuronal Cx36 gap junction channel blockage

Epilepsy is one of the most prevalent neurological disorders and can result in neuronal injury and degeneration. Consequently, research into new antiepileptic drugs capable of providing protection against neuronal injury and degeneration is extremely important. Neuronal Cx36 gap junction channels ha...

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Autores principales:	Wang Guangliang, Wu Xuemei
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	neuroprotection cx36 channel blocker epilepsy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/1cec98e0dc604b1e9cd463c1145c1ef8
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spelling	oai:doaj.org-article:1cec98e0dc604b1e9cd463c1145c1ef82021-12-05T14:11:05ZThe potential antiepileptogenic effect of neuronal Cx36 gap junction channel blockage2081-693610.1515/tnsci-2021-0008https://doaj.org/article/1cec98e0dc604b1e9cd463c1145c1ef82021-01-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2021-0008https://doaj.org/toc/2081-6936Epilepsy is one of the most prevalent neurological disorders and can result in neuronal injury and degeneration. Consequently, research into new antiepileptic drugs capable of providing protection against neuronal injury and degeneration is extremely important. Neuronal Cx36 gap junction channels have been found to play an important role in epilepsy; thus, pharmacological interference using Cx36 gap junction channel blockers may be a promising strategy for disrupting the synchronization of neurons during seizure activity and protecting neurons. Based on these promising findings, several in vivo and in vitro studies are ongoing and the first encouraging results have been published. The results bring hope that neurons can be protected from injury and degeneration in patients with epilepsy, which is currently impossible.Wang GuangliangWu XuemeiDe Gruyterarticleneuroprotectioncx36 channel blockerepilepsyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 12, Iss 1, Pp 46-51 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuroprotection cx36 channel blocker epilepsy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	neuroprotection cx36 channel blocker epilepsy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Wang Guangliang Wu Xuemei The potential antiepileptogenic effect of neuronal Cx36 gap junction channel blockage
description	Epilepsy is one of the most prevalent neurological disorders and can result in neuronal injury and degeneration. Consequently, research into new antiepileptic drugs capable of providing protection against neuronal injury and degeneration is extremely important. Neuronal Cx36 gap junction channels have been found to play an important role in epilepsy; thus, pharmacological interference using Cx36 gap junction channel blockers may be a promising strategy for disrupting the synchronization of neurons during seizure activity and protecting neurons. Based on these promising findings, several in vivo and in vitro studies are ongoing and the first encouraging results have been published. The results bring hope that neurons can be protected from injury and degeneration in patients with epilepsy, which is currently impossible.
format	article
author	Wang Guangliang Wu Xuemei
author_facet	Wang Guangliang Wu Xuemei
author_sort	Wang Guangliang
title	The potential antiepileptogenic effect of neuronal Cx36 gap junction channel blockage
title_short	The potential antiepileptogenic effect of neuronal Cx36 gap junction channel blockage
title_full	The potential antiepileptogenic effect of neuronal Cx36 gap junction channel blockage
title_fullStr	The potential antiepileptogenic effect of neuronal Cx36 gap junction channel blockage
title_full_unstemmed	The potential antiepileptogenic effect of neuronal Cx36 gap junction channel blockage
title_sort	potential antiepileptogenic effect of neuronal cx36 gap junction channel blockage
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/1cec98e0dc604b1e9cd463c1145c1ef8
work_keys_str_mv	AT wangguangliang thepotentialantiepileptogeniceffectofneuronalcx36gapjunctionchannelblockage AT wuxuemei thepotentialantiepileptogeniceffectofneuronalcx36gapjunctionchannelblockage AT wangguangliang potentialantiepileptogeniceffectofneuronalcx36gapjunctionchannelblockage AT wuxuemei potentialantiepileptogeniceffectofneuronalcx36gapjunctionchannelblockage
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The potential antiepileptogenic effect of neuronal Cx36 gap junction channel blockage

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