HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130

Checkpoint kinases control cell cycle progression via the regulation of many key regulators. Here the authors demonstrate how HDAC1 and HDAC2 modulate checkpoint kinase signalling via the suppression of PR130, a regulatory subunit of the trimeric serine/threonine phosphatase 2.

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Autores principales:	Anja Göder, Claudia Emmerich, Teodora Nikolova, Nicole Kiweler, Maria Schreiber, Toni Kühl, Diana Imhof, Markus Christmann, Thorsten Heinzel, Günter Schneider, Oliver H. Krämer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1ced4836ae484e558c659722b88a91e8
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spelling	oai:doaj.org-article:1ced4836ae484e558c659722b88a91e82021-12-02T16:49:33ZHDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR13010.1038/s41467-018-03096-02041-1723https://doaj.org/article/1ced4836ae484e558c659722b88a91e82018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03096-0https://doaj.org/toc/2041-1723Checkpoint kinases control cell cycle progression via the regulation of many key regulators. Here the authors demonstrate how HDAC1 and HDAC2 modulate checkpoint kinase signalling via the suppression of PR130, a regulatory subunit of the trimeric serine/threonine phosphatase 2.Anja GöderClaudia EmmerichTeodora NikolovaNicole KiwelerMaria SchreiberToni KühlDiana ImhofMarkus ChristmannThorsten HeinzelGünter SchneiderOliver H. KrämerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anja Göder Claudia Emmerich Teodora Nikolova Nicole Kiweler Maria Schreiber Toni Kühl Diana Imhof Markus Christmann Thorsten Heinzel Günter Schneider Oliver H. Krämer HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130
description	Checkpoint kinases control cell cycle progression via the regulation of many key regulators. Here the authors demonstrate how HDAC1 and HDAC2 modulate checkpoint kinase signalling via the suppression of PR130, a regulatory subunit of the trimeric serine/threonine phosphatase 2.
format	article
author	Anja Göder Claudia Emmerich Teodora Nikolova Nicole Kiweler Maria Schreiber Toni Kühl Diana Imhof Markus Christmann Thorsten Heinzel Günter Schneider Oliver H. Krämer
author_facet	Anja Göder Claudia Emmerich Teodora Nikolova Nicole Kiweler Maria Schreiber Toni Kühl Diana Imhof Markus Christmann Thorsten Heinzel Günter Schneider Oliver H. Krämer
author_sort	Anja Göder
title	HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130
title_short	HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130
title_full	HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130
title_fullStr	HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130
title_full_unstemmed	HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130
title_sort	hdac1 and hdac2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2a subunit pr130
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1ced4836ae484e558c659722b88a91e8
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HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130

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