Preference of Women for Gestational Diabetes Screening Method According to Tolerance of Tests and Population Characteristics

AimsTo determine the preferred method of screening for gestational diabetes mellitus (GDM).Methods1804 women from a prospective study (NCT02036619) received a glucose challenge test (GCT) and 75g oral glucose tolerance test (OGTT) between 24-28 weeks. Tolerance of screening tests and preference for...

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Autores principales:	Lore Raets, Marie Vandewinkel, Paul Van Crombrugge, Carolien Moyson, Johan Verhaeghe, Sofie Vandeginste, Hilde Verlaenen, Chris Vercammen, Toon Maes, Els Dufraimont, Nele Roggen, Christophe De Block, Yves Jacquemyn, Farah Mekahli, Katrien De Clippel, Annick Van Den Bruel, Anne Loccufier, Annouschka Laenen, Roland Devlieger, Chantal Mathieu, Katrien Benhalima
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	gestational diabetes mellitus preference for screening method tolerance glucose challenge test two-step screening one-step screening Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/1ced71f208234d709400affb42645f48
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spelling	oai:doaj.org-article:1ced71f208234d709400affb42645f482021-11-08T14:24:17ZPreference of Women for Gestational Diabetes Screening Method According to Tolerance of Tests and Population Characteristics1664-239210.3389/fendo.2021.781384https://doaj.org/article/1ced71f208234d709400affb42645f482021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.781384/fullhttps://doaj.org/toc/1664-2392AimsTo determine the preferred method of screening for gestational diabetes mellitus (GDM).Methods1804 women from a prospective study (NCT02036619) received a glucose challenge test (GCT) and 75g oral glucose tolerance test (OGTT) between 24-28 weeks. Tolerance of screening tests and preference for screening strategy (two-step screening strategy with GCT compared to one-step screening strategy with OGTT) were evaluated by a self-designed questionnaire at the time of the GCT and OGTT.ResultsCompared to women who preferred one-step screening [26.2% (472)], women who preferred two-step screening [46.3% (834)] were less often from a minor ethnic background [6.0% (50) vs. 10.7% (50), p=0.003], had less often a previous history of GDM [7.3% (29) vs. 13.8% (32), p=0.008], were less often overweight or obese [respectively 23.1% (50) vs. 24.8% (116), p<0.001 and 7.9% (66) vs. 18.2% (85), p<0.001], were less insulin resistant in early pregnancy (HOMA-IR 8.9 (6.4-12.3) vs. 9.9 (7.2-14.2), p<0.001], and pregnancy outcomes were similar except for fewer labor inductions and emergency cesarean sections [respectively 26.6% (198) vs. 32.5% (137), p=0.031 and 8.2% (68) vs. 13.0% (61), p=0.005]. Women who preferred two-step screening had more often complaints of the OGTT compared to women who preferred one-step screening [50.4% (420) vs. 40.3% (190), p<0.001].ConclusionsA two-step GDM screening involving a GCT and subsequent OGTT is the preferred GDM screening strategy. Women with a more adverse metabolic profile preferred one-step screening with OGTT while women preferring two-step screening had a better metabolic profile and more discomfort of the OGTT. The preference for the GDM screening method is in line with the recommended Flemish modified two-step screening method, in which women at higher risk for GDM are recommended a one-step screening strategy with an OGTT, while women without these risk factors, are offered a two-step screening strategy with GCT.Clinical Trial RegistrationNCT02036619 https://clinicaltrials.gov/ct2/show/NCT02036619Lore RaetsMarie VandewinkelPaul Van CrombruggeCarolien MoysonJohan VerhaegheSofie VandeginsteHilde VerlaenenChris VercammenToon MaesEls DufraimontNele RoggenChristophe De BlockYves JacquemynFarah MekahliKatrien De ClippelAnnick Van Den BruelAnne LoccufierAnnouschka LaenenRoland DevliegerChantal MathieuKatrien BenhalimaFrontiers Media S.A.articlegestational diabetes mellituspreference for screening methodtoleranceglucose challenge testtwo-step screeningone-step screeningDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gestational diabetes mellitus preference for screening method tolerance glucose challenge test two-step screening one-step screening Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	gestational diabetes mellitus preference for screening method tolerance glucose challenge test two-step screening one-step screening Diseases of the endocrine glands. Clinical endocrinology RC648-665 Lore Raets Marie Vandewinkel Paul Van Crombrugge Carolien Moyson Johan Verhaeghe Sofie Vandeginste Hilde Verlaenen Chris Vercammen Toon Maes Els Dufraimont Nele Roggen Christophe De Block Yves Jacquemyn Farah Mekahli Katrien De Clippel Annick Van Den Bruel Anne Loccufier Annouschka Laenen Roland Devlieger Chantal Mathieu Katrien Benhalima Preference of Women for Gestational Diabetes Screening Method According to Tolerance of Tests and Population Characteristics
description	AimsTo determine the preferred method of screening for gestational diabetes mellitus (GDM).Methods1804 women from a prospective study (NCT02036619) received a glucose challenge test (GCT) and 75g oral glucose tolerance test (OGTT) between 24-28 weeks. Tolerance of screening tests and preference for screening strategy (two-step screening strategy with GCT compared to one-step screening strategy with OGTT) were evaluated by a self-designed questionnaire at the time of the GCT and OGTT.ResultsCompared to women who preferred one-step screening [26.2% (472)], women who preferred two-step screening [46.3% (834)] were less often from a minor ethnic background [6.0% (50) vs. 10.7% (50), p=0.003], had less often a previous history of GDM [7.3% (29) vs. 13.8% (32), p=0.008], were less often overweight or obese [respectively 23.1% (50) vs. 24.8% (116), p<0.001 and 7.9% (66) vs. 18.2% (85), p<0.001], were less insulin resistant in early pregnancy (HOMA-IR 8.9 (6.4-12.3) vs. 9.9 (7.2-14.2), p<0.001], and pregnancy outcomes were similar except for fewer labor inductions and emergency cesarean sections [respectively 26.6% (198) vs. 32.5% (137), p=0.031 and 8.2% (68) vs. 13.0% (61), p=0.005]. Women who preferred two-step screening had more often complaints of the OGTT compared to women who preferred one-step screening [50.4% (420) vs. 40.3% (190), p<0.001].ConclusionsA two-step GDM screening involving a GCT and subsequent OGTT is the preferred GDM screening strategy. Women with a more adverse metabolic profile preferred one-step screening with OGTT while women preferring two-step screening had a better metabolic profile and more discomfort of the OGTT. The preference for the GDM screening method is in line with the recommended Flemish modified two-step screening method, in which women at higher risk for GDM are recommended a one-step screening strategy with an OGTT, while women without these risk factors, are offered a two-step screening strategy with GCT.Clinical Trial RegistrationNCT02036619 https://clinicaltrials.gov/ct2/show/NCT02036619
format	article
author	Lore Raets Marie Vandewinkel Paul Van Crombrugge Carolien Moyson Johan Verhaeghe Sofie Vandeginste Hilde Verlaenen Chris Vercammen Toon Maes Els Dufraimont Nele Roggen Christophe De Block Yves Jacquemyn Farah Mekahli Katrien De Clippel Annick Van Den Bruel Anne Loccufier Annouschka Laenen Roland Devlieger Chantal Mathieu Katrien Benhalima
author_facet	Lore Raets Marie Vandewinkel Paul Van Crombrugge Carolien Moyson Johan Verhaeghe Sofie Vandeginste Hilde Verlaenen Chris Vercammen Toon Maes Els Dufraimont Nele Roggen Christophe De Block Yves Jacquemyn Farah Mekahli Katrien De Clippel Annick Van Den Bruel Anne Loccufier Annouschka Laenen Roland Devlieger Chantal Mathieu Katrien Benhalima
author_sort	Lore Raets
title	Preference of Women for Gestational Diabetes Screening Method According to Tolerance of Tests and Population Characteristics
title_short	Preference of Women for Gestational Diabetes Screening Method According to Tolerance of Tests and Population Characteristics
title_full	Preference of Women for Gestational Diabetes Screening Method According to Tolerance of Tests and Population Characteristics
title_fullStr	Preference of Women for Gestational Diabetes Screening Method According to Tolerance of Tests and Population Characteristics
title_full_unstemmed	Preference of Women for Gestational Diabetes Screening Method According to Tolerance of Tests and Population Characteristics
title_sort	preference of women for gestational diabetes screening method according to tolerance of tests and population characteristics
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/1ced71f208234d709400affb42645f48
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Preference of Women for Gestational Diabetes Screening Method According to Tolerance of Tests and Population Characteristics

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