Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses

Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses

DNA barcoding is a promising technology for the simultaneous analysis of genetic and phenotypic heterogeneity. Here, the authors combine DNA barcoding and single-cell RNA-seq to study heterogeneity, progression and response to therapy in B-cell acute lymphoblastic leukaemia patient-derived xenograft...

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Auteurs principaux: Humberto Contreras-Trujillo, Jiya Eerdeng, Samir Akre, Du Jiang, Jorge Contreras, Basia Gala, Mary C. Vergel-Rodriguez, Yeachan Lee, Aparna Jorapur, Areen Andreasian, Lisa Harton, Charles S. Bramlett, Anna Nogalska, Gang Xiao, Jae-Woong Lee, Lai N. Chan, Markus Müschen, Akil A. Merchant, Rong Lu
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/1cf0a0d2c96e4d41be8c44bd2d61e2d2
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Résumé:DNA barcoding is a promising technology for the simultaneous analysis of genetic and phenotypic heterogeneity. Here, the authors combine DNA barcoding and single-cell RNA-seq to study heterogeneity, progression and response to therapy in B-cell acute lymphoblastic leukaemia patient-derived xenografts.

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