Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses

DNA barcoding is a promising technology for the simultaneous analysis of genetic and phenotypic heterogeneity. Here, the authors combine DNA barcoding and single-cell RNA-seq to study heterogeneity, progression and response to therapy in B-cell acute lymphoblastic leukaemia patient-derived xenograft...

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Autores principales:	Humberto Contreras-Trujillo, Jiya Eerdeng, Samir Akre, Du Jiang, Jorge Contreras, Basia Gala, Mary C. Vergel-Rodriguez, Yeachan Lee, Aparna Jorapur, Areen Andreasian, Lisa Harton, Charles S. Bramlett, Anna Nogalska, Gang Xiao, Jae-Woong Lee, Lai N. Chan, Markus Müschen, Akil A. Merchant, Rong Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1cf0a0d2c96e4d41be8c44bd2d61e2d2
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spelling	oai:doaj.org-article:1cf0a0d2c96e4d41be8c44bd2d61e2d22021-11-14T12:36:42ZDeciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses10.1038/s41467-021-26771-12041-1723https://doaj.org/article/1cf0a0d2c96e4d41be8c44bd2d61e2d22021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26771-1https://doaj.org/toc/2041-1723DNA barcoding is a promising technology for the simultaneous analysis of genetic and phenotypic heterogeneity. Here, the authors combine DNA barcoding and single-cell RNA-seq to study heterogeneity, progression and response to therapy in B-cell acute lymphoblastic leukaemia patient-derived xenografts.Humberto Contreras-TrujilloJiya EerdengSamir AkreDu JiangJorge ContrerasBasia GalaMary C. Vergel-RodriguezYeachan LeeAparna JorapurAreen AndreasianLisa HartonCharles S. BramlettAnna NogalskaGang XiaoJae-Woong LeeLai N. ChanMarkus MüschenAkil A. MerchantRong LuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Humberto Contreras-Trujillo Jiya Eerdeng Samir Akre Du Jiang Jorge Contreras Basia Gala Mary C. Vergel-Rodriguez Yeachan Lee Aparna Jorapur Areen Andreasian Lisa Harton Charles S. Bramlett Anna Nogalska Gang Xiao Jae-Woong Lee Lai N. Chan Markus Müschen Akil A. Merchant Rong Lu Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses
description	DNA barcoding is a promising technology for the simultaneous analysis of genetic and phenotypic heterogeneity. Here, the authors combine DNA barcoding and single-cell RNA-seq to study heterogeneity, progression and response to therapy in B-cell acute lymphoblastic leukaemia patient-derived xenografts.
format	article
author	Humberto Contreras-Trujillo Jiya Eerdeng Samir Akre Du Jiang Jorge Contreras Basia Gala Mary C. Vergel-Rodriguez Yeachan Lee Aparna Jorapur Areen Andreasian Lisa Harton Charles S. Bramlett Anna Nogalska Gang Xiao Jae-Woong Lee Lai N. Chan Markus Müschen Akil A. Merchant Rong Lu
author_facet	Humberto Contreras-Trujillo Jiya Eerdeng Samir Akre Du Jiang Jorge Contreras Basia Gala Mary C. Vergel-Rodriguez Yeachan Lee Aparna Jorapur Areen Andreasian Lisa Harton Charles S. Bramlett Anna Nogalska Gang Xiao Jae-Woong Lee Lai N. Chan Markus Müschen Akil A. Merchant Rong Lu
author_sort	Humberto Contreras-Trujillo
title	Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses
title_short	Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses
title_full	Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses
title_fullStr	Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses
title_full_unstemmed	Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses
title_sort	deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1cf0a0d2c96e4d41be8c44bd2d61e2d2
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Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses

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