Visible-light driven Photoelectrochemical Immunosensor Based on SnS2@mpg-C3N4 for Detection of Prostate Specific Antigen

Abstract Herein, a novel label-free photoelectrochemical (PEC) immunosensor based on SnS2@mpg-C3N4 nanocomposite is fabricated for the detection of prostate specific antigen (PSA) in human serum. Firstly, mesoporous graphite-like carbon nitride (mpg-C3N4) with carboxyl groups is synthesized successf...

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Autores principales:	Yifeng Zhang, Yixin Liu, Rongxia Li, Malik Saddam Khan, Picheng Gao, Yong Zhang, Qin Wei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1cf27f06ec424772b4624b4cc372a39d
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spelling	oai:doaj.org-article:1cf27f06ec424772b4624b4cc372a39d2021-12-02T16:08:24ZVisible-light driven Photoelectrochemical Immunosensor Based on SnS2@mpg-C3N4 for Detection of Prostate Specific Antigen10.1038/s41598-017-04924-x2045-2322https://doaj.org/article/1cf27f06ec424772b4624b4cc372a39d2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04924-xhttps://doaj.org/toc/2045-2322Abstract Herein, a novel label-free photoelectrochemical (PEC) immunosensor based on SnS2@mpg-C3N4 nanocomposite is fabricated for the detection of prostate specific antigen (PSA) in human serum. Firstly, mesoporous graphite-like carbon nitride (mpg-C3N4) with carboxyl groups is synthesized successfully which possesses high specific surface area and large pore volume. Then, SnS2 as a typical n-type semiconductor with weak photoelectric conversion capability is successfully loaded on carboxylated mpg-C3N4 to form a well-matched overlapping band-structure. The as-synthesized SnS2@mpg-C3N4 nanocomposite performs outstanding photocurrent response under visible-light irradiation due to low recombination rate of photoexcited electron-hole pairs, which is transcend than pure SnS2 or pure mpg-C3N4. It is worth noting that SnS2@mpg-C3N4 nanocomposite is firstly employed as the photoactive material in PEC immunosensor area. The concentration of PSA can be analyzed by the decrease in photocurrent resulted from increased steric hindrance of the immunocomplex. Under the optimal conditions, the developed PEC immunosensor displays a liner photocurrent response in the range of 50 fg·mL−1 ~ 10 ng·mL−1 with a low detection limit of 21 fg·mL−1. Furthermore, the fabricated immunosensor with satisfactory stability, reproducibility and selectivity provides a novel method for PSA determination in real sample analysis.Yifeng ZhangYixin LiuRongxia LiMalik Saddam KhanPicheng GaoYong ZhangQin WeiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yifeng Zhang Yixin Liu Rongxia Li Malik Saddam Khan Picheng Gao Yong Zhang Qin Wei Visible-light driven Photoelectrochemical Immunosensor Based on SnS2@mpg-C3N4 for Detection of Prostate Specific Antigen
description	Abstract Herein, a novel label-free photoelectrochemical (PEC) immunosensor based on SnS2@mpg-C3N4 nanocomposite is fabricated for the detection of prostate specific antigen (PSA) in human serum. Firstly, mesoporous graphite-like carbon nitride (mpg-C3N4) with carboxyl groups is synthesized successfully which possesses high specific surface area and large pore volume. Then, SnS2 as a typical n-type semiconductor with weak photoelectric conversion capability is successfully loaded on carboxylated mpg-C3N4 to form a well-matched overlapping band-structure. The as-synthesized SnS2@mpg-C3N4 nanocomposite performs outstanding photocurrent response under visible-light irradiation due to low recombination rate of photoexcited electron-hole pairs, which is transcend than pure SnS2 or pure mpg-C3N4. It is worth noting that SnS2@mpg-C3N4 nanocomposite is firstly employed as the photoactive material in PEC immunosensor area. The concentration of PSA can be analyzed by the decrease in photocurrent resulted from increased steric hindrance of the immunocomplex. Under the optimal conditions, the developed PEC immunosensor displays a liner photocurrent response in the range of 50 fg·mL−1 ~ 10 ng·mL−1 with a low detection limit of 21 fg·mL−1. Furthermore, the fabricated immunosensor with satisfactory stability, reproducibility and selectivity provides a novel method for PSA determination in real sample analysis.
format	article
author	Yifeng Zhang Yixin Liu Rongxia Li Malik Saddam Khan Picheng Gao Yong Zhang Qin Wei
author_facet	Yifeng Zhang Yixin Liu Rongxia Li Malik Saddam Khan Picheng Gao Yong Zhang Qin Wei
author_sort	Yifeng Zhang
title	Visible-light driven Photoelectrochemical Immunosensor Based on SnS2@mpg-C3N4 for Detection of Prostate Specific Antigen
title_short	Visible-light driven Photoelectrochemical Immunosensor Based on SnS2@mpg-C3N4 for Detection of Prostate Specific Antigen
title_full	Visible-light driven Photoelectrochemical Immunosensor Based on SnS2@mpg-C3N4 for Detection of Prostate Specific Antigen
title_fullStr	Visible-light driven Photoelectrochemical Immunosensor Based on SnS2@mpg-C3N4 for Detection of Prostate Specific Antigen
title_full_unstemmed	Visible-light driven Photoelectrochemical Immunosensor Based on SnS2@mpg-C3N4 for Detection of Prostate Specific Antigen
title_sort	visible-light driven photoelectrochemical immunosensor based on sns2@mpg-c3n4 for detection of prostate specific antigen
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1cf27f06ec424772b4624b4cc372a39d
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Visible-light driven Photoelectrochemical Immunosensor Based on SnS2@mpg-C3N4 for Detection of Prostate Specific Antigen

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