Protection patterns in duck and chicken after homo- or hetero-subtypic reinfections with H5 and H7 low pathogenicity avian influenza viruses: a comparative study.

Avian influenza viruses are circulating continuously in ducks, inducing a mostly asymptomatic infection, while chickens are accidental hosts highly susceptible to respiratory disease. This discrepancy might be due to a different host response to the virus between these two bird species and in partic...

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Autores principales:	Coralie Chaise, Anne-Christine Lalmanach, Hélène Marty, Sébastien Mathieu Soubies, Guillaume Croville, Josyane Loupias, Daniel Marc, Pascale Quéré, Jean-Luc Guérin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1cf875e65efc49d6ac3068f6825f3164
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spelling	oai:doaj.org-article:1cf875e65efc49d6ac3068f6825f31642021-11-25T06:03:23ZProtection patterns in duck and chicken after homo- or hetero-subtypic reinfections with H5 and H7 low pathogenicity avian influenza viruses: a comparative study.1932-620310.1371/journal.pone.0105189https://doaj.org/article/1cf875e65efc49d6ac3068f6825f31642014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25153201/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Avian influenza viruses are circulating continuously in ducks, inducing a mostly asymptomatic infection, while chickens are accidental hosts highly susceptible to respiratory disease. This discrepancy might be due to a different host response to the virus between these two bird species and in particular to a different susceptibility to reinfection. In an attempt to address this question, we analyzed, in ducks and in chickens, the viral load in infected tissues and the humoral immune response after experimental primary and secondary challenge infections with either homologous or heterologous low pathogenicity avian influenza viruses (LPAIV). Following homologous reinfection, ducks were only partially protected against viral shedding in the lower intestine in conjunction with a moderate antibody response, whereas chickens were totally protected against viral shedding in the upper respiratory airways and developed a stronger antibody response. On the contrary, heterologous reinfection was not followed by a reduced viral excretion in the upper airways of chickens, while ducks were still partially protected from intestinal excretion of the virus, with no correlation to the antibody response. Our comparative study provides a comprehensive demonstration of the variation of viral tropism and control of the host humoral response to LPAIV between two different bird species with different degrees of susceptibility to avian influenza.Coralie ChaiseAnne-Christine LalmanachHélène MartySébastien Mathieu SoubiesGuillaume CrovilleJosyane LoupiasDaniel MarcPascale QuéréJean-Luc GuérinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e105189 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Coralie Chaise Anne-Christine Lalmanach Hélène Marty Sébastien Mathieu Soubies Guillaume Croville Josyane Loupias Daniel Marc Pascale Quéré Jean-Luc Guérin Protection patterns in duck and chicken after homo- or hetero-subtypic reinfections with H5 and H7 low pathogenicity avian influenza viruses: a comparative study.
description	Avian influenza viruses are circulating continuously in ducks, inducing a mostly asymptomatic infection, while chickens are accidental hosts highly susceptible to respiratory disease. This discrepancy might be due to a different host response to the virus between these two bird species and in particular to a different susceptibility to reinfection. In an attempt to address this question, we analyzed, in ducks and in chickens, the viral load in infected tissues and the humoral immune response after experimental primary and secondary challenge infections with either homologous or heterologous low pathogenicity avian influenza viruses (LPAIV). Following homologous reinfection, ducks were only partially protected against viral shedding in the lower intestine in conjunction with a moderate antibody response, whereas chickens were totally protected against viral shedding in the upper respiratory airways and developed a stronger antibody response. On the contrary, heterologous reinfection was not followed by a reduced viral excretion in the upper airways of chickens, while ducks were still partially protected from intestinal excretion of the virus, with no correlation to the antibody response. Our comparative study provides a comprehensive demonstration of the variation of viral tropism and control of the host humoral response to LPAIV between two different bird species with different degrees of susceptibility to avian influenza.
format	article
author	Coralie Chaise Anne-Christine Lalmanach Hélène Marty Sébastien Mathieu Soubies Guillaume Croville Josyane Loupias Daniel Marc Pascale Quéré Jean-Luc Guérin
author_facet	Coralie Chaise Anne-Christine Lalmanach Hélène Marty Sébastien Mathieu Soubies Guillaume Croville Josyane Loupias Daniel Marc Pascale Quéré Jean-Luc Guérin
author_sort	Coralie Chaise
title	Protection patterns in duck and chicken after homo- or hetero-subtypic reinfections with H5 and H7 low pathogenicity avian influenza viruses: a comparative study.
title_short	Protection patterns in duck and chicken after homo- or hetero-subtypic reinfections with H5 and H7 low pathogenicity avian influenza viruses: a comparative study.
title_full	Protection patterns in duck and chicken after homo- or hetero-subtypic reinfections with H5 and H7 low pathogenicity avian influenza viruses: a comparative study.
title_fullStr	Protection patterns in duck and chicken after homo- or hetero-subtypic reinfections with H5 and H7 low pathogenicity avian influenza viruses: a comparative study.
title_full_unstemmed	Protection patterns in duck and chicken after homo- or hetero-subtypic reinfections with H5 and H7 low pathogenicity avian influenza viruses: a comparative study.
title_sort	protection patterns in duck and chicken after homo- or hetero-subtypic reinfections with h5 and h7 low pathogenicity avian influenza viruses: a comparative study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/1cf875e65efc49d6ac3068f6825f3164
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Protection patterns in duck and chicken after homo- or hetero-subtypic reinfections with H5 and H7 low pathogenicity avian influenza viruses: a comparative study.

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