Using electrocochleography to detect sensory and neural damages in a gerbil model

Abstract Hearing is one of the five sensory organs that allows us to interact with society and our environment. However, one in eight Americans suffers from sensorineural hearing loss that is great enough to adversely impact their daily life. There is an urgent need to identify what part/degree of t...

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Autores principales:	Sebastiaan W. F. Meenderink, Xiaohui Lin, Wei Dong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1cf8ffc773da46e98db2f87df214c8ca
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spelling	oai:doaj.org-article:1cf8ffc773da46e98db2f87df214c8ca2021-12-02T17:37:12ZUsing electrocochleography to detect sensory and neural damages in a gerbil model10.1038/s41598-021-98658-62045-2322https://doaj.org/article/1cf8ffc773da46e98db2f87df214c8ca2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98658-6https://doaj.org/toc/2045-2322Abstract Hearing is one of the five sensory organs that allows us to interact with society and our environment. However, one in eight Americans suffers from sensorineural hearing loss that is great enough to adversely impact their daily life. There is an urgent need to identify what part/degree of the auditory pathway (sensory or neural) is compromised so that appropriate treatment/intervention can be implemented. Single- or two-tone evoked potentials, the electrocochleography (eCochG), were measured along the auditory pathway, i.e., at the round window and remotely at the vertex, with simultaneous recordings of ear canal distortion product otoacoustic emissions. Sensory (cochlear) and neural components in the (remote-) eCochG responses showed distinct level- and frequency-dependent features allowing to be differentiated from each other. Specifically, the distortion products in the (remote-)eCochGs can precisely localize the sensory damage showing that they are effective to determine the sensory or neural damage along the auditory pathway.Sebastiaan W. F. MeenderinkXiaohui LinWei DongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sebastiaan W. F. Meenderink Xiaohui Lin Wei Dong Using electrocochleography to detect sensory and neural damages in a gerbil model
description	Abstract Hearing is one of the five sensory organs that allows us to interact with society and our environment. However, one in eight Americans suffers from sensorineural hearing loss that is great enough to adversely impact their daily life. There is an urgent need to identify what part/degree of the auditory pathway (sensory or neural) is compromised so that appropriate treatment/intervention can be implemented. Single- or two-tone evoked potentials, the electrocochleography (eCochG), were measured along the auditory pathway, i.e., at the round window and remotely at the vertex, with simultaneous recordings of ear canal distortion product otoacoustic emissions. Sensory (cochlear) and neural components in the (remote-) eCochG responses showed distinct level- and frequency-dependent features allowing to be differentiated from each other. Specifically, the distortion products in the (remote-)eCochGs can precisely localize the sensory damage showing that they are effective to determine the sensory or neural damage along the auditory pathway.
format	article
author	Sebastiaan W. F. Meenderink Xiaohui Lin Wei Dong
author_facet	Sebastiaan W. F. Meenderink Xiaohui Lin Wei Dong
author_sort	Sebastiaan W. F. Meenderink
title	Using electrocochleography to detect sensory and neural damages in a gerbil model
title_short	Using electrocochleography to detect sensory and neural damages in a gerbil model
title_full	Using electrocochleography to detect sensory and neural damages in a gerbil model
title_fullStr	Using electrocochleography to detect sensory and neural damages in a gerbil model
title_full_unstemmed	Using electrocochleography to detect sensory and neural damages in a gerbil model
title_sort	using electrocochleography to detect sensory and neural damages in a gerbil model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1cf8ffc773da46e98db2f87df214c8ca
work_keys_str_mv	AT sebastiaanwfmeenderink usingelectrocochleographytodetectsensoryandneuraldamagesinagerbilmodel AT xiaohuilin usingelectrocochleographytodetectsensoryandneuraldamagesinagerbilmodel AT weidong usingelectrocochleographytodetectsensoryandneuraldamagesinagerbilmodel
_version_	1718379869913481216

Using electrocochleography to detect sensory and neural damages in a gerbil model

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