Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation

Yuki Omori,1 Takashi Kanbayashi,1,2 Yohei Sagawa,1 Aya Imanishi,1 Ko Tsutsui,1 Yuya Takahashi,1 Masahiro Takeshima,1 Manabu Takaki,3 Seiji Nishino,4 Tetsuo Shimizu1,2 1Department of Neuropsychiatry, Akita University Graduate School of Medicine, Akita, Japan; 2International Institute for Integrative...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Omori Y, Kanbayashi T, Sagawa Y, Imanishi A, Tsutsui K, Takahashi Y, Takeshima M, Takaki M, Nishino S, Shimizu T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	delayed sleep phase syndrome aripiprazole total sleep time Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/1cfb2ffd8db947c4a1438a8d3d903fe6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1cfb2ffd8db947c4a1438a8d3d903fe6
record_format	dspace
spelling	oai:doaj.org-article:1cfb2ffd8db947c4a1438a8d3d903fe62021-12-02T00:23:12ZLow dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation1178-2021https://doaj.org/article/1cfb2ffd8db947c4a1438a8d3d903fe62018-05-01T00:00:00Zhttps://www.dovepress.com/low-dose-of-aripiprazole-advanced-sleep-rhythm-and-reduced-nocturnal-s-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yuki Omori,1 Takashi Kanbayashi,1,2 Yohei Sagawa,1 Aya Imanishi,1 Ko Tsutsui,1 Yuya Takahashi,1 Masahiro Takeshima,1 Manabu Takaki,3 Seiji Nishino,4 Tetsuo Shimizu1,2 1Department of Neuropsychiatry, Akita University Graduate School of Medicine, Akita, Japan; 2International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan; 3Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Okayama, Japan; 4Department of Psychiatry and Behavioral Sciences, Sleep and Circadian Neurobiology Laboratory & Center for Narcolepsy, Stanford University School of Medicine, Stanford, CA, USA Objectives: Delayed sleep phase syndrome (DSPS) is a chronic dysfunction of circadian rhythm of the subject that impairs functioning in social, occupational, or other spheres. High rate of depression is found among DSPS patients. Aripiprazole (APZ), a second-generation antipsychotic, is effective in treatment of depression as well as schizophrenia. Recently, few case reports show the effectiveness of APZ in treating DSPS and non-24-hour sleep–wake rhythm disorder. Therefore, we tried to treat DSPS with depression using APZ.Methods: Twelve subjects (including four women) aged 19–64 years were included. The subjects were prescribed initially 0.5–3 mg of APZ once a day with subsequent dose adjustments.Results: Sleep onset, midpoint of sleep, and sleep offset were significantly advanced by 1.1, 1.8, and 2.5 hours, respectively. Unexpectedly, sleep duration became significantly shorter by 1.3 hours after treatment. Their depressive moods showed an unremarkable change.Conclusion: Low dose of APZ advanced the sleep rhythm and reduced nocturnal sleep time in the subjects with DSPS. Since it is not easy for physicians to treat prolonged sleep duration often associated with DSPS, this medication would become a new therapeutic option for these patients. Keywords: delayed sleep phase syndrome, aripiprazole, total sleep timeOmori YKanbayashi TSagawa YImanishi ATsutsui KTakahashi YTakeshima MTakaki MNishino SShimizu TDove Medical Pressarticledelayed sleep phase syndromearipiprazoletotal sleep timeNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 1281-1286 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	delayed sleep phase syndrome aripiprazole total sleep time Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	delayed sleep phase syndrome aripiprazole total sleep time Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Omori Y Kanbayashi T Sagawa Y Imanishi A Tsutsui K Takahashi Y Takeshima M Takaki M Nishino S Shimizu T Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation
description	Yuki Omori,1 Takashi Kanbayashi,1,2 Yohei Sagawa,1 Aya Imanishi,1 Ko Tsutsui,1 Yuya Takahashi,1 Masahiro Takeshima,1 Manabu Takaki,3 Seiji Nishino,4 Tetsuo Shimizu1,2 1Department of Neuropsychiatry, Akita University Graduate School of Medicine, Akita, Japan; 2International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan; 3Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Okayama, Japan; 4Department of Psychiatry and Behavioral Sciences, Sleep and Circadian Neurobiology Laboratory & Center for Narcolepsy, Stanford University School of Medicine, Stanford, CA, USA Objectives: Delayed sleep phase syndrome (DSPS) is a chronic dysfunction of circadian rhythm of the subject that impairs functioning in social, occupational, or other spheres. High rate of depression is found among DSPS patients. Aripiprazole (APZ), a second-generation antipsychotic, is effective in treatment of depression as well as schizophrenia. Recently, few case reports show the effectiveness of APZ in treating DSPS and non-24-hour sleep–wake rhythm disorder. Therefore, we tried to treat DSPS with depression using APZ.Methods: Twelve subjects (including four women) aged 19–64 years were included. The subjects were prescribed initially 0.5–3 mg of APZ once a day with subsequent dose adjustments.Results: Sleep onset, midpoint of sleep, and sleep offset were significantly advanced by 1.1, 1.8, and 2.5 hours, respectively. Unexpectedly, sleep duration became significantly shorter by 1.3 hours after treatment. Their depressive moods showed an unremarkable change.Conclusion: Low dose of APZ advanced the sleep rhythm and reduced nocturnal sleep time in the subjects with DSPS. Since it is not easy for physicians to treat prolonged sleep duration often associated with DSPS, this medication would become a new therapeutic option for these patients. Keywords: delayed sleep phase syndrome, aripiprazole, total sleep time
format	article
author	Omori Y Kanbayashi T Sagawa Y Imanishi A Tsutsui K Takahashi Y Takeshima M Takaki M Nishino S Shimizu T
author_facet	Omori Y Kanbayashi T Sagawa Y Imanishi A Tsutsui K Takahashi Y Takeshima M Takaki M Nishino S Shimizu T
author_sort	Omori Y
title	Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation
title_short	Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation
title_full	Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation
title_fullStr	Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation
title_full_unstemmed	Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation
title_sort	low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/1cfb2ffd8db947c4a1438a8d3d903fe6
work_keys_str_mv	AT omoriy lowdoseofaripiprazoleadvancedsleeprhythmandreducednocturnalsleeptimeinthepatientswithdelayedsleepphasesyndromeanopenlabeledclinicalobservation AT kanbayashit lowdoseofaripiprazoleadvancedsleeprhythmandreducednocturnalsleeptimeinthepatientswithdelayedsleepphasesyndromeanopenlabeledclinicalobservation AT sagaway lowdoseofaripiprazoleadvancedsleeprhythmandreducednocturnalsleeptimeinthepatientswithdelayedsleepphasesyndromeanopenlabeledclinicalobservation AT imanishia lowdoseofaripiprazoleadvancedsleeprhythmandreducednocturnalsleeptimeinthepatientswithdelayedsleepphasesyndromeanopenlabeledclinicalobservation AT tsutsuik lowdoseofaripiprazoleadvancedsleeprhythmandreducednocturnalsleeptimeinthepatientswithdelayedsleepphasesyndromeanopenlabeledclinicalobservation AT takahashiy lowdoseofaripiprazoleadvancedsleeprhythmandreducednocturnalsleeptimeinthepatientswithdelayedsleepphasesyndromeanopenlabeledclinicalobservation AT takeshimam lowdoseofaripiprazoleadvancedsleeprhythmandreducednocturnalsleeptimeinthepatientswithdelayedsleepphasesyndromeanopenlabeledclinicalobservation AT takakim lowdoseofaripiprazoleadvancedsleeprhythmandreducednocturnalsleeptimeinthepatientswithdelayedsleepphasesyndromeanopenlabeledclinicalobservation AT nishinos lowdoseofaripiprazoleadvancedsleeprhythmandreducednocturnalsleeptimeinthepatientswithdelayedsleepphasesyndromeanopenlabeledclinicalobservation AT shimizut lowdoseofaripiprazoleadvancedsleeprhythmandreducednocturnalsleeptimeinthepatientswithdelayedsleepphasesyndromeanopenlabeledclinicalobservation
_version_	1718403726842003456

Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation

Ejemplares similares