Allele variants of HLA II genes DRB1 and DQB1 regarding risk for type 1 diabetes mellitus in population of Bashkortostan

Aims. To estimate significance of HLA II DRB1 and DRB2 allele variants for development of type 1 diabetes mellitus (T1DM) in Bashkortostanpopulation (ethnical Russians, Tatar, Bashkir). Materials and methods. We analyzed DNA of 323 patients with T1DM and 683 healthy controls. DNA was derived from...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shamilevna Avzaletdinova, Tatiana Vyacheslavovna Morugova, Olga Evgen'evna Mustafina
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2012
Materias:	diabetes mellitus type 1 genetic predisposition hla Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/1cfca0c45ec446feb08d3a620c2af1c1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1cfca0c45ec446feb08d3a620c2af1c1
record_format	dspace
spelling	oai:doaj.org-article:1cfca0c45ec446feb08d3a620c2af1c12021-11-14T09:00:17ZAllele variants of HLA II genes DRB1 and DQB1 regarding risk for type 1 diabetes mellitus in population of Bashkortostan2072-03512072-037810.14341/2072-0351-6081https://doaj.org/article/1cfca0c45ec446feb08d3a620c2af1c12012-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6081https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aims. To estimate significance of HLA II DRB1 and DRB2 allele variants for development of type 1 diabetes mellitus (T1DM) in Bashkortostanpopulation (ethnical Russians, Tatar, Bashkir). Materials and methods. We analyzed DNA of 323 patients with T1DM and 683 healthy controls. DNA was derived from venous bloodsamples by phenol-chloroform extraction. DRB1 and DQB1 gene typing was performed by PCR method. Amplification products wereidentified with electrophoresis on a 1% agarose gel. Statistica for Windows v6.0 and MS Excel 98 software were applied for statisticalprocessing of acquired data. Results. Common markers of high risk for T1DM were found to be DRB104, DRB117, genotype DRB104/17. On the contrary,lower risk was associated with DRB115 allele. In ethnical Russians lower risk of T1DM is also determined by DRB111 allele andDRB101 in Tatars. Predisposition by DQB1-alleles in Russians and Bashkir realizes only within DRB104/17 genotype. However,in Tatar subpopulation DQB10302 is an independent risk marker of T1DM development. Conclusion. Common low risk markers for all three ethnic groups are DQB10301, DQB10602-08 alleles. Their presence negates riskof disease in all studied subpopulations even within DRB104/17-genotype.Shamilevna AvzaletdinovaTatiana Vyacheslavovna MorugovaOlga Evgen'evna MustafinaEndocrinology Research Centrearticlediabetes mellitus type 1genetic predispositionhlaNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 15, Iss 3, Pp 18-23 (2012)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus type 1 genetic predisposition hla Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus type 1 genetic predisposition hla Nutritional diseases. Deficiency diseases RC620-627 Shamilevna Avzaletdinova Tatiana Vyacheslavovna Morugova Olga Evgen'evna Mustafina Allele variants of HLA II genes DRB1 and DQB1 regarding risk for type 1 diabetes mellitus in population of Bashkortostan
description	Aims. To estimate significance of HLA II DRB1 and DRB2 allele variants for development of type 1 diabetes mellitus (T1DM) in Bashkortostanpopulation (ethnical Russians, Tatar, Bashkir). Materials and methods. We analyzed DNA of 323 patients with T1DM and 683 healthy controls. DNA was derived from venous bloodsamples by phenol-chloroform extraction. DRB1 and DQB1 gene typing was performed by PCR method. Amplification products wereidentified with electrophoresis on a 1% agarose gel. Statistica for Windows v6.0 and MS Excel 98 software were applied for statisticalprocessing of acquired data. Results. Common markers of high risk for T1DM were found to be DRB104, DRB117, genotype DRB104/17. On the contrary,lower risk was associated with DRB115 allele. In ethnical Russians lower risk of T1DM is also determined by DRB111 allele andDRB101 in Tatars. Predisposition by DQB1-alleles in Russians and Bashkir realizes only within DRB104/17 genotype. However,in Tatar subpopulation DQB10302 is an independent risk marker of T1DM development. Conclusion. Common low risk markers for all three ethnic groups are DQB10301, DQB10602-08 alleles. Their presence negates riskof disease in all studied subpopulations even within DRB104/17-genotype.
format	article
author	Shamilevna Avzaletdinova Tatiana Vyacheslavovna Morugova Olga Evgen'evna Mustafina
author_facet	Shamilevna Avzaletdinova Tatiana Vyacheslavovna Morugova Olga Evgen'evna Mustafina
author_sort	Shamilevna Avzaletdinova
title	Allele variants of HLA II genes DRB1 and DQB1 regarding risk for type 1 diabetes mellitus in population of Bashkortostan
title_short	Allele variants of HLA II genes DRB1 and DQB1 regarding risk for type 1 diabetes mellitus in population of Bashkortostan
title_full	Allele variants of HLA II genes DRB1 and DQB1 regarding risk for type 1 diabetes mellitus in population of Bashkortostan
title_fullStr	Allele variants of HLA II genes DRB1 and DQB1 regarding risk for type 1 diabetes mellitus in population of Bashkortostan
title_full_unstemmed	Allele variants of HLA II genes DRB1 and DQB1 regarding risk for type 1 diabetes mellitus in population of Bashkortostan
title_sort	allele variants of hla ii genes drb1 and dqb1 regarding risk for type 1 diabetes mellitus in population of bashkortostan
publisher	Endocrinology Research Centre
publishDate	2012
url	https://doaj.org/article/1cfca0c45ec446feb08d3a620c2af1c1
work_keys_str_mv	AT shamilevnaavzaletdinova allelevariantsofhlaiigenesdrb1anddqb1regardingriskfortype1diabetesmellitusinpopulationofbashkortostan AT tatianavyacheslavovnamorugova allelevariantsofhlaiigenesdrb1anddqb1regardingriskfortype1diabetesmellitusinpopulationofbashkortostan AT olgaevgenevnamustafina allelevariantsofhlaiigenesdrb1anddqb1regardingriskfortype1diabetesmellitusinpopulationofbashkortostan
_version_	1718429573532614656

Allele variants of HLA II genes DRB1 and DQB1 regarding risk for type 1 diabetes mellitus in population of Bashkortostan

Ejemplares similares