Chemotherapy with cisplatin: insights into intracellular pH and metabolic landscape of cancer cells in vitro and in vivo

Abstract Although cisplatin plays a central role in cancer chemotherapy, the mechanisms of cell response to this drug have been unexplored. The present study demonstrates the relationships between the intracellular pH (pHi), cell bioenergetics and the response of cervical cancer to cisplatin. pHi wa...

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Autores principales: Marina V. Shirmanova, Irina N. Druzhkova, Maria M. Lukina, Varvara V. Dudenkova, Nadezhda I. Ignatova, Ludmila B. Snopova, Vladislav I. Shcheslavskiy, Vsevolod V. Belousov, Elena V. Zagaynova
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/1d01ca27978b4309907f9f361f19b0c0
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