Nanostructured lipid carriers based suppository for enhanced rectal absorption of ondansetron: In vitro and in vivo evaluations

The current research aimed to fabricate ondansetron nanostructured lipid carriers (OND-NLCs) and incorporate them into a suppository base to manage chemotherapy-induced vomiting and nausea, which offer the advantage of both rapid onset and prolonged release. NLCs were fabricated by adopting the solv...

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Autores principales:	Badriyah Shadid Alotaibi, Fahad Pervaiz, Manal Buabeid, Akram Ashames, Khairi Mustafa Fahelelbom, Sana Siddique, Hina Shoukat, Sadia Rehman, Sobia Noreen, Ghulam Murtaza
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Nanostructured lipid carriers Ondansetron Oleic acid Lauric acid Rectal suppository Emesis Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/1d024d51499f44f0bf048d547d8a7846
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spelling	oai:doaj.org-article:1d024d51499f44f0bf048d547d8a78462021-11-20T04:57:49ZNanostructured lipid carriers based suppository for enhanced rectal absorption of ondansetron: In vitro and in vivo evaluations1878-535210.1016/j.arabjc.2021.103426https://doaj.org/article/1d024d51499f44f0bf048d547d8a78462021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S187853522100441Xhttps://doaj.org/toc/1878-5352The current research aimed to fabricate ondansetron nanostructured lipid carriers (OND-NLCs) and incorporate them into a suppository base to manage chemotherapy-induced vomiting and nausea, which offer the advantage of both rapid onset and prolonged release. NLCs were fabricated by adopting the solvent diffusion method. The binary lipid mixture of oleic acid (liquid lipid) and lauric acid (solid lipid) were prepared in distinct ratios. The NLCs were characterized concerning the surface charge, size, drug encapsulation efficiency, and surface morphology. In addition, the influence of surfactant, co-surfactant, and lipid on entrapment efficiency and particle size was investigated. Phosphate buffer having pH 7.4 is used for evaluating in vitro drug release by utilizing a dialysis membrane. Various kinetics models were used to estimate the drug release kinetics of fabricated nanostructured lipid carriers. The particle size of the NLCs was calculated between 101 and 378 nm with negative zeta potential on the NLC’s surface. The entrapment efficiency was found between 68 and 87%. Scanning Electron Microscopic analysis showed the spherical shape of nanostructured lipid carriers. The dissolution profile of the ondansetron-loaded NLC suppository depicts biphasic behavior of firstly burst release then slow release was observed. The diffusion controlled release was evident from kinetic modeling. The succeeding step comprehended the fabrication and characterization of NLC-based suppositories utilizing NLC formulations that demonstrated the combined advantage of rapid onset, prolonged release, and better in vivo bioavailability as compared to control suppository.Badriyah Shadid AlotaibiFahad PervaizManal BuabeidAkram AshamesKhairi Mustafa FahelelbomSana SiddiqueHina ShoukatSadia RehmanSobia NoreenGhulam MurtazaElsevierarticleNanostructured lipid carriersOndansetronOleic acidLauric acidRectal suppositoryEmesisChemistryQD1-999ENArabian Journal of Chemistry, Vol 14, Iss 12, Pp 103426- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nanostructured lipid carriers Ondansetron Oleic acid Lauric acid Rectal suppository Emesis Chemistry QD1-999
spellingShingle	Nanostructured lipid carriers Ondansetron Oleic acid Lauric acid Rectal suppository Emesis Chemistry QD1-999 Badriyah Shadid Alotaibi Fahad Pervaiz Manal Buabeid Akram Ashames Khairi Mustafa Fahelelbom Sana Siddique Hina Shoukat Sadia Rehman Sobia Noreen Ghulam Murtaza Nanostructured lipid carriers based suppository for enhanced rectal absorption of ondansetron: In vitro and in vivo evaluations
description	The current research aimed to fabricate ondansetron nanostructured lipid carriers (OND-NLCs) and incorporate them into a suppository base to manage chemotherapy-induced vomiting and nausea, which offer the advantage of both rapid onset and prolonged release. NLCs were fabricated by adopting the solvent diffusion method. The binary lipid mixture of oleic acid (liquid lipid) and lauric acid (solid lipid) were prepared in distinct ratios. The NLCs were characterized concerning the surface charge, size, drug encapsulation efficiency, and surface morphology. In addition, the influence of surfactant, co-surfactant, and lipid on entrapment efficiency and particle size was investigated. Phosphate buffer having pH 7.4 is used for evaluating in vitro drug release by utilizing a dialysis membrane. Various kinetics models were used to estimate the drug release kinetics of fabricated nanostructured lipid carriers. The particle size of the NLCs was calculated between 101 and 378 nm with negative zeta potential on the NLC’s surface. The entrapment efficiency was found between 68 and 87%. Scanning Electron Microscopic analysis showed the spherical shape of nanostructured lipid carriers. The dissolution profile of the ondansetron-loaded NLC suppository depicts biphasic behavior of firstly burst release then slow release was observed. The diffusion controlled release was evident from kinetic modeling. The succeeding step comprehended the fabrication and characterization of NLC-based suppositories utilizing NLC formulations that demonstrated the combined advantage of rapid onset, prolonged release, and better in vivo bioavailability as compared to control suppository.
format	article
author	Badriyah Shadid Alotaibi Fahad Pervaiz Manal Buabeid Akram Ashames Khairi Mustafa Fahelelbom Sana Siddique Hina Shoukat Sadia Rehman Sobia Noreen Ghulam Murtaza
author_facet	Badriyah Shadid Alotaibi Fahad Pervaiz Manal Buabeid Akram Ashames Khairi Mustafa Fahelelbom Sana Siddique Hina Shoukat Sadia Rehman Sobia Noreen Ghulam Murtaza
author_sort	Badriyah Shadid Alotaibi
title	Nanostructured lipid carriers based suppository for enhanced rectal absorption of ondansetron: In vitro and in vivo evaluations
title_short	Nanostructured lipid carriers based suppository for enhanced rectal absorption of ondansetron: In vitro and in vivo evaluations
title_full	Nanostructured lipid carriers based suppository for enhanced rectal absorption of ondansetron: In vitro and in vivo evaluations
title_fullStr	Nanostructured lipid carriers based suppository for enhanced rectal absorption of ondansetron: In vitro and in vivo evaluations
title_full_unstemmed	Nanostructured lipid carriers based suppository for enhanced rectal absorption of ondansetron: In vitro and in vivo evaluations
title_sort	nanostructured lipid carriers based suppository for enhanced rectal absorption of ondansetron: in vitro and in vivo evaluations
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/1d024d51499f44f0bf048d547d8a7846
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Nanostructured lipid carriers based suppository for enhanced rectal absorption of ondansetron: In vitro and in vivo evaluations

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