Clay Minerals as Bioink Ingredients for 3D Printing and 3D Bioprinting: Application in Tissue Engineering and Regenerative Medicine

The adaptation and progress of 3D printing technology toward 3D bioprinting (specifically adapted to biomedical purposes) has opened the door to a world of new opportunities and possibilities in tissue engineering and regenerative medicine. In this regard, 3D bioprinting allows for the production of...

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Autores principales:	Fátima García-Villén, Sandra Ruiz-Alonso, Markel Lafuente-Merchan, Idoia Gallego, Myriam Sainz-Ramos, Laura Saenz-del-Burgo, Jose Luis Pedraz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	clay nanosilicate phyllosilicate tissue engineering regenerative medicine 3D printing Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/1d087c630b6848429aac97064b8fe586
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spelling	oai:doaj.org-article:1d087c630b6848429aac97064b8fe5862021-11-25T18:40:49ZClay Minerals as Bioink Ingredients for 3D Printing and 3D Bioprinting: Application in Tissue Engineering and Regenerative Medicine10.3390/pharmaceutics131118061999-4923https://doaj.org/article/1d087c630b6848429aac97064b8fe5862021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1806https://doaj.org/toc/1999-4923The adaptation and progress of 3D printing technology toward 3D bioprinting (specifically adapted to biomedical purposes) has opened the door to a world of new opportunities and possibilities in tissue engineering and regenerative medicine. In this regard, 3D bioprinting allows for the production of tailor-made constructs and organs as well as the production of custom implants and medical devices. As it is a growing field of study, currently, the attention is heeded on the optimization and improvement of the mechanical and biological properties of the so-called bioinks/biomaterial inks. One of the strategies proposed is the use of inorganic ingredients (clays, hydroxyapatite, graphene, carbon nanotubes and other silicate nanoparticles). Clays have proven to be useful as rheological and mechanical reinforcement in a wide range of fields, from the building industry to pharmacy. Moreover, they are naturally occurring materials with recognized biocompatibility and bioactivity, revealing them as optimal candidates for this cutting-edge technology. This review deals with the use of clays (both natural and synthetic) for tissue engineering and regenerative medicine through 3D printing and bioprinting. Despite the limited number of studies, it is possible to conclude that clays play a fundamental role in the formulation and optimization of bioinks and biomaterial inks since they are able to improve their rheology and mechanical properties, thus improving printability and construct resistance. Additionally, they have also proven to be exceptionally functional ingredients (enhancing cellular proliferation, adhesion, differentiation and alignment), controlling biodegradation and carrying/releasing actives with tissue regeneration therapeutic activities.Fátima García-VillénSandra Ruiz-AlonsoMarkel Lafuente-MerchanIdoia GallegoMyriam Sainz-RamosLaura Saenz-del-BurgoJose Luis PedrazMDPI AGarticleclaynanosilicatephyllosilicatetissue engineeringregenerative medicine3D printingPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1806, p 1806 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	clay nanosilicate phyllosilicate tissue engineering regenerative medicine 3D printing Pharmacy and materia medica RS1-441
spellingShingle	clay nanosilicate phyllosilicate tissue engineering regenerative medicine 3D printing Pharmacy and materia medica RS1-441 Fátima García-Villén Sandra Ruiz-Alonso Markel Lafuente-Merchan Idoia Gallego Myriam Sainz-Ramos Laura Saenz-del-Burgo Jose Luis Pedraz Clay Minerals as Bioink Ingredients for 3D Printing and 3D Bioprinting: Application in Tissue Engineering and Regenerative Medicine
description	The adaptation and progress of 3D printing technology toward 3D bioprinting (specifically adapted to biomedical purposes) has opened the door to a world of new opportunities and possibilities in tissue engineering and regenerative medicine. In this regard, 3D bioprinting allows for the production of tailor-made constructs and organs as well as the production of custom implants and medical devices. As it is a growing field of study, currently, the attention is heeded on the optimization and improvement of the mechanical and biological properties of the so-called bioinks/biomaterial inks. One of the strategies proposed is the use of inorganic ingredients (clays, hydroxyapatite, graphene, carbon nanotubes and other silicate nanoparticles). Clays have proven to be useful as rheological and mechanical reinforcement in a wide range of fields, from the building industry to pharmacy. Moreover, they are naturally occurring materials with recognized biocompatibility and bioactivity, revealing them as optimal candidates for this cutting-edge technology. This review deals with the use of clays (both natural and synthetic) for tissue engineering and regenerative medicine through 3D printing and bioprinting. Despite the limited number of studies, it is possible to conclude that clays play a fundamental role in the formulation and optimization of bioinks and biomaterial inks since they are able to improve their rheology and mechanical properties, thus improving printability and construct resistance. Additionally, they have also proven to be exceptionally functional ingredients (enhancing cellular proliferation, adhesion, differentiation and alignment), controlling biodegradation and carrying/releasing actives with tissue regeneration therapeutic activities.
format	article
author	Fátima García-Villén Sandra Ruiz-Alonso Markel Lafuente-Merchan Idoia Gallego Myriam Sainz-Ramos Laura Saenz-del-Burgo Jose Luis Pedraz
author_facet	Fátima García-Villén Sandra Ruiz-Alonso Markel Lafuente-Merchan Idoia Gallego Myriam Sainz-Ramos Laura Saenz-del-Burgo Jose Luis Pedraz
author_sort	Fátima García-Villén
title	Clay Minerals as Bioink Ingredients for 3D Printing and 3D Bioprinting: Application in Tissue Engineering and Regenerative Medicine
title_short	Clay Minerals as Bioink Ingredients for 3D Printing and 3D Bioprinting: Application in Tissue Engineering and Regenerative Medicine
title_full	Clay Minerals as Bioink Ingredients for 3D Printing and 3D Bioprinting: Application in Tissue Engineering and Regenerative Medicine
title_fullStr	Clay Minerals as Bioink Ingredients for 3D Printing and 3D Bioprinting: Application in Tissue Engineering and Regenerative Medicine
title_full_unstemmed	Clay Minerals as Bioink Ingredients for 3D Printing and 3D Bioprinting: Application in Tissue Engineering and Regenerative Medicine
title_sort	clay minerals as bioink ingredients for 3d printing and 3d bioprinting: application in tissue engineering and regenerative medicine
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1d087c630b6848429aac97064b8fe586
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Clay Minerals as Bioink Ingredients for 3D Printing and 3D Bioprinting: Application in Tissue Engineering and Regenerative Medicine

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