Leveraging the Cell Ontology to classify unseen cell types

Classifying cells into unseen cell types remains challenging in scRNA-seq analysis. Here we show that Cell Ontology enables an accurate classification of unseen cell types through considering the cell type relationships in the Cell Ontology graph.

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Autores principales:	Sheng Wang, Angela Oliveira Pisco, Aaron McGeever, Maria Brbic, Marinka Zitnik, Spyros Darmanis, Jure Leskovec, Jim Karkanias, Russ B. Altman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d09fe5933a6428fb050655243e85aa0
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spelling	oai:doaj.org-article:1d09fe5933a6428fb050655243e85aa02021-12-02T17:27:12ZLeveraging the Cell Ontology to classify unseen cell types10.1038/s41467-021-25725-x2041-1723https://doaj.org/article/1d09fe5933a6428fb050655243e85aa02021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25725-xhttps://doaj.org/toc/2041-1723Classifying cells into unseen cell types remains challenging in scRNA-seq analysis. Here we show that Cell Ontology enables an accurate classification of unseen cell types through considering the cell type relationships in the Cell Ontology graph.Sheng WangAngela Oliveira PiscoAaron McGeeverMaria BrbicMarinka ZitnikSpyros DarmanisJure LeskovecJim KarkaniasRuss B. AltmanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sheng Wang Angela Oliveira Pisco Aaron McGeever Maria Brbic Marinka Zitnik Spyros Darmanis Jure Leskovec Jim Karkanias Russ B. Altman Leveraging the Cell Ontology to classify unseen cell types
description	Classifying cells into unseen cell types remains challenging in scRNA-seq analysis. Here we show that Cell Ontology enables an accurate classification of unseen cell types through considering the cell type relationships in the Cell Ontology graph.
format	article
author	Sheng Wang Angela Oliveira Pisco Aaron McGeever Maria Brbic Marinka Zitnik Spyros Darmanis Jure Leskovec Jim Karkanias Russ B. Altman
author_facet	Sheng Wang Angela Oliveira Pisco Aaron McGeever Maria Brbic Marinka Zitnik Spyros Darmanis Jure Leskovec Jim Karkanias Russ B. Altman
author_sort	Sheng Wang
title	Leveraging the Cell Ontology to classify unseen cell types
title_short	Leveraging the Cell Ontology to classify unseen cell types
title_full	Leveraging the Cell Ontology to classify unseen cell types
title_fullStr	Leveraging the Cell Ontology to classify unseen cell types
title_full_unstemmed	Leveraging the Cell Ontology to classify unseen cell types
title_sort	leveraging the cell ontology to classify unseen cell types
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1d09fe5933a6428fb050655243e85aa0
work_keys_str_mv	AT shengwang leveragingthecellontologytoclassifyunseencelltypes AT angelaoliveirapisco leveragingthecellontologytoclassifyunseencelltypes AT aaronmcgeever leveragingthecellontologytoclassifyunseencelltypes AT mariabrbic leveragingthecellontologytoclassifyunseencelltypes AT marinkazitnik leveragingthecellontologytoclassifyunseencelltypes AT spyrosdarmanis leveragingthecellontologytoclassifyunseencelltypes AT jureleskovec leveragingthecellontologytoclassifyunseencelltypes AT jimkarkanias leveragingthecellontologytoclassifyunseencelltypes AT russbaltman leveragingthecellontologytoclassifyunseencelltypes
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Leveraging the Cell Ontology to classify unseen cell types

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