Manually scanned single fiber optical coherence tomography for skin cancer characterization

Abstract Optical coherence tomography (OCT) is a cross-sectional imaging modality based on low coherence light interferometry. Within dermatology, it has found applications for in vivo diagnostic imaging purposes, as well as to guide Mohs micrographic surgery (MMS), due to its ability to visualize s...

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Autores principales:	Nadiya Chuchvara, Babar Rao, Xuan Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1d0f210d8c144b01a428124b6b5fbf9b
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spelling	oai:doaj.org-article:1d0f210d8c144b01a428124b6b5fbf9b2021-12-02T16:06:43ZManually scanned single fiber optical coherence tomography for skin cancer characterization10.1038/s41598-021-95118-z2045-2322https://doaj.org/article/1d0f210d8c144b01a428124b6b5fbf9b2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95118-zhttps://doaj.org/toc/2045-2322Abstract Optical coherence tomography (OCT) is a cross-sectional imaging modality based on low coherence light interferometry. Within dermatology, it has found applications for in vivo diagnostic imaging purposes, as well as to guide Mohs micrographic surgery (MMS), due to its ability to visualize skin morphology up to several millimeters in depth. However, standard OCT probes have a large footprint and capture an extended area of the skin, making it difficult to precisely pinpoint clinically relevant location being imaged. Mohs surgeons stand to benefit from a handheld in vivo imaging device that can accurately trace surgical margins. In this study, we demonstrate the use of a single fiber OCT (sfOCT) instrument. Our imaging system features a miniature common path single fiber probe, and a novel speckle decorrelation technique that generates distortion free 2D images from manual scanning.By manually moving the single-fiber probe across the region of interest, the user can perform a lateral OCT scan while visualizing the location of the probe during data acquisition. Using the sfOCT, we have identified normal skin morphology, qualitatively correlated features of basal cell carcinoma and squamous cell carcinoma with histopathology, and quantified the disruption of the dermo-epidermal junction OCT pattern in skin tumors—each demonstrating the potential of utilizing sfOCT to differentiate tumor from normal skin. Using this imaging tool, a Mohs surgeon can enhance determination of surgical margins for the first stage of MMS, potentially decreasing the time and number of stages required for complete tumor removal.Nadiya ChuchvaraBabar RaoXuan LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nadiya Chuchvara Babar Rao Xuan Liu Manually scanned single fiber optical coherence tomography for skin cancer characterization
description	Abstract Optical coherence tomography (OCT) is a cross-sectional imaging modality based on low coherence light interferometry. Within dermatology, it has found applications for in vivo diagnostic imaging purposes, as well as to guide Mohs micrographic surgery (MMS), due to its ability to visualize skin morphology up to several millimeters in depth. However, standard OCT probes have a large footprint and capture an extended area of the skin, making it difficult to precisely pinpoint clinically relevant location being imaged. Mohs surgeons stand to benefit from a handheld in vivo imaging device that can accurately trace surgical margins. In this study, we demonstrate the use of a single fiber OCT (sfOCT) instrument. Our imaging system features a miniature common path single fiber probe, and a novel speckle decorrelation technique that generates distortion free 2D images from manual scanning.By manually moving the single-fiber probe across the region of interest, the user can perform a lateral OCT scan while visualizing the location of the probe during data acquisition. Using the sfOCT, we have identified normal skin morphology, qualitatively correlated features of basal cell carcinoma and squamous cell carcinoma with histopathology, and quantified the disruption of the dermo-epidermal junction OCT pattern in skin tumors—each demonstrating the potential of utilizing sfOCT to differentiate tumor from normal skin. Using this imaging tool, a Mohs surgeon can enhance determination of surgical margins for the first stage of MMS, potentially decreasing the time and number of stages required for complete tumor removal.
format	article
author	Nadiya Chuchvara Babar Rao Xuan Liu
author_facet	Nadiya Chuchvara Babar Rao Xuan Liu
author_sort	Nadiya Chuchvara
title	Manually scanned single fiber optical coherence tomography for skin cancer characterization
title_short	Manually scanned single fiber optical coherence tomography for skin cancer characterization
title_full	Manually scanned single fiber optical coherence tomography for skin cancer characterization
title_fullStr	Manually scanned single fiber optical coherence tomography for skin cancer characterization
title_full_unstemmed	Manually scanned single fiber optical coherence tomography for skin cancer characterization
title_sort	manually scanned single fiber optical coherence tomography for skin cancer characterization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1d0f210d8c144b01a428124b6b5fbf9b
work_keys_str_mv	AT nadiyachuchvara manuallyscannedsinglefiberopticalcoherencetomographyforskincancercharacterization AT babarrao manuallyscannedsinglefiberopticalcoherencetomographyforskincancercharacterization AT xuanliu manuallyscannedsinglefiberopticalcoherencetomographyforskincancercharacterization
_version_	1718384888750538752

Manually scanned single fiber optical coherence tomography for skin cancer characterization

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