GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans

Dysfunction of the trabecular meshwork (TM) is the chief cause of elevated intraocular pressure, the major risk factor of glaucoma. Here, the authors identify the transcription factor, GLIS1, as a critical regulator of TM maintenance and intraocular pressure, and as a glaucoma risk gene.

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Autores principales:	K. Saidas Nair, Chitrangda Srivastava, Robert V. Brown, Swanand Koli, Hélène Choquet, Hong Soon Kang, Yien-Ming Kuo, Sara A. Grimm, Caleb Sutherland, Alexandra Badea, G. Allan Johnson, Yin Zhao, Jie Yin, Kyoko Okamoto, Graham Clark, Terete Borrás, Gulab Zode, Krishnakumar Kizhatil, Subhabrata Chakrabarti, Simon W. M. John, Eric Jorgenson, Anton M. Jetten
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d13ccf102314720a834e165f6b1a62d
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spelling	oai:doaj.org-article:1d13ccf102314720a834e165f6b1a62d2021-12-02T18:50:56ZGLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans10.1038/s41467-021-25181-72041-1723https://doaj.org/article/1d13ccf102314720a834e165f6b1a62d2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25181-7https://doaj.org/toc/2041-1723Dysfunction of the trabecular meshwork (TM) is the chief cause of elevated intraocular pressure, the major risk factor of glaucoma. Here, the authors identify the transcription factor, GLIS1, as a critical regulator of TM maintenance and intraocular pressure, and as a glaucoma risk gene.K. Saidas NairChitrangda SrivastavaRobert V. BrownSwanand KoliHélène ChoquetHong Soon KangYien-Ming KuoSara A. GrimmCaleb SutherlandAlexandra BadeaG. Allan JohnsonYin ZhaoJie YinKyoko OkamotoGraham ClarkTerete BorrásGulab ZodeKrishnakumar KizhatilSubhabrata ChakrabartiSimon W. M. JohnEric JorgensonAnton M. JettenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q K. Saidas Nair Chitrangda Srivastava Robert V. Brown Swanand Koli Hélène Choquet Hong Soon Kang Yien-Ming Kuo Sara A. Grimm Caleb Sutherland Alexandra Badea G. Allan Johnson Yin Zhao Jie Yin Kyoko Okamoto Graham Clark Terete Borrás Gulab Zode Krishnakumar Kizhatil Subhabrata Chakrabarti Simon W. M. John Eric Jorgenson Anton M. Jetten GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans
description	Dysfunction of the trabecular meshwork (TM) is the chief cause of elevated intraocular pressure, the major risk factor of glaucoma. Here, the authors identify the transcription factor, GLIS1, as a critical regulator of TM maintenance and intraocular pressure, and as a glaucoma risk gene.
format	article
author	K. Saidas Nair Chitrangda Srivastava Robert V. Brown Swanand Koli Hélène Choquet Hong Soon Kang Yien-Ming Kuo Sara A. Grimm Caleb Sutherland Alexandra Badea G. Allan Johnson Yin Zhao Jie Yin Kyoko Okamoto Graham Clark Terete Borrás Gulab Zode Krishnakumar Kizhatil Subhabrata Chakrabarti Simon W. M. John Eric Jorgenson Anton M. Jetten
author_facet	K. Saidas Nair Chitrangda Srivastava Robert V. Brown Swanand Koli Hélène Choquet Hong Soon Kang Yien-Ming Kuo Sara A. Grimm Caleb Sutherland Alexandra Badea G. Allan Johnson Yin Zhao Jie Yin Kyoko Okamoto Graham Clark Terete Borrás Gulab Zode Krishnakumar Kizhatil Subhabrata Chakrabarti Simon W. M. John Eric Jorgenson Anton M. Jetten
author_sort	K. Saidas Nair
title	GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans
title_short	GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans
title_full	GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans
title_fullStr	GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans
title_full_unstemmed	GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans
title_sort	glis1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1d13ccf102314720a834e165f6b1a62d
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GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans

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