Anti-inflammatory activity of a natural herbal-marine drug (MS14 - SANT and SUSP) compared to sodium salicylate or methylprednisolone in a rat model for multiple sclerosis

A natural compound of marine herbal origin has been used in Persian Traditional Medicine to relieve some symptoms of multiple sclerosis. The present study investigated the anti-inflammatory effects of a patented extracts of the traditional receipt (MS14). In this preliminary experiment, we used sev...

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Autores principales:	Mohsen Naseri, Hossein Rezaeizadeh, Mahdi Mirghazanfari, Taiebeh Taheripanah, Zahra Bararpoor, Neda Ashayeri, Majid Asghari, Abbas Talebi Mazrae Shahi, Fatemeh Emadi, Parvaneh Mohseni Moghaddam, Abbas Hashemi Nejad, Farzaneh Ghaffari
Formato:	article
Lenguaje:	EN
Publicado:	PAGEPress Publications 2021
Materias:	Traditional Persian Medicine Penaeus latisculatus Apium graveolens Hypericum perforatum MS14 anti-inflammatory action Medicine R Human anatomy QM1-695
Acceso en línea:	https://doaj.org/article/1d14d961cf1c4f6b8e0151e219301589
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spelling	oai:doaj.org-article:1d14d961cf1c4f6b8e0151e2193015892021-11-24T21:40:18ZAnti-inflammatory activity of a natural herbal-marine drug (MS14 - SANT and SUSP) compared to sodium salicylate or methylprednisolone in a rat model for multiple sclerosis10.4081/ejtm.2022.101692037-74522037-7460https://doaj.org/article/1d14d961cf1c4f6b8e0151e2193015892021-11-01T00:00:00Zhttps://www.pagepressjournals.org/index.php/bam/article/view/10169https://doaj.org/toc/2037-7452https://doaj.org/toc/2037-7460 A natural compound of marine herbal origin has been used in Persian Traditional Medicine to relieve some symptoms of multiple sclerosis. The present study investigated the anti-inflammatory effects of a patented extracts of the traditional receipt (MS14). In this preliminary experiment, we used seven groups of six rats: the control group received vehicle, the two positive control groups were treated with either sodium salicylate (300 mg/kg) intraperitoneal (i.p.) or methyl prednisolon (MPN 10 mg/kg) i.p., while the test groups were treated with a solution centrifuged MS14 (SANT 100 mg/kg) and suspension of MS14 (SUSP 100, 150, 300 mg/kg) i.p. After thirty minutes, paw volume was measured by plethysmometer and immediately formalin solution was injected subcutaneously into the hind paw and after an hour, inflamed paw volume was measured. In days 2-8, the inflamed paw volume was measured and immediately drugs were injected i.p. The anti-inflammatory effect of MPN was significant only on days 5 and 6. The anti-inflammatory effect of SS was significant only on the 6th day, while the anti-inflammatory effect of SANT MS14 (100 mg/kg) was also significant only on the 6th day. SUSP MS14 (150 mg/kg) significantly reduced edema from second to 6th day. Intra-peritoneal injection of SUSP MS14 with 300 mg/kg was toxic, so excluded from the study. This research indicates that the MS14 possesses an anti-inflammatory effect after intra-peritoneal administration. Comparative anti-inflammatory effects of MS14 with Glucocorticoids in this study, may justify a possible mechanism for its action in multiple sclerosis, if further studies will provid strong statistically confirmatory effects in animals and safety human trials. Mohsen NaseriHossein RezaeizadehMahdi MirghazanfariTaiebeh TaheripanahZahra BararpoorNeda AshayeriMajid AsghariAbbas Talebi Mazrae ShahiFatemeh EmadiParvaneh Mohseni MoghaddamAbbas Hashemi NejadFarzaneh GhaffariPAGEPress PublicationsarticleTraditional Persian MedicinePenaeus latisculatusApium graveolensHypericum perforatumMS14anti-inflammatory actionMedicineRHuman anatomyQM1-695ENEuropean Journal of Translational Myology (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Traditional Persian Medicine Penaeus latisculatus Apium graveolens Hypericum perforatum MS14 anti-inflammatory action Medicine R Human anatomy QM1-695
spellingShingle	Traditional Persian Medicine Penaeus latisculatus Apium graveolens Hypericum perforatum MS14 anti-inflammatory action Medicine R Human anatomy QM1-695 Mohsen Naseri Hossein Rezaeizadeh Mahdi Mirghazanfari Taiebeh Taheripanah Zahra Bararpoor Neda Ashayeri Majid Asghari Abbas Talebi Mazrae Shahi Fatemeh Emadi Parvaneh Mohseni Moghaddam Abbas Hashemi Nejad Farzaneh Ghaffari Anti-inflammatory activity of a natural herbal-marine drug (MS14 - SANT and SUSP) compared to sodium salicylate or methylprednisolone in a rat model for multiple sclerosis
description	A natural compound of marine herbal origin has been used in Persian Traditional Medicine to relieve some symptoms of multiple sclerosis. The present study investigated the anti-inflammatory effects of a patented extracts of the traditional receipt (MS14). In this preliminary experiment, we used seven groups of six rats: the control group received vehicle, the two positive control groups were treated with either sodium salicylate (300 mg/kg) intraperitoneal (i.p.) or methyl prednisolon (MPN 10 mg/kg) i.p., while the test groups were treated with a solution centrifuged MS14 (SANT 100 mg/kg) and suspension of MS14 (SUSP 100, 150, 300 mg/kg) i.p. After thirty minutes, paw volume was measured by plethysmometer and immediately formalin solution was injected subcutaneously into the hind paw and after an hour, inflamed paw volume was measured. In days 2-8, the inflamed paw volume was measured and immediately drugs were injected i.p. The anti-inflammatory effect of MPN was significant only on days 5 and 6. The anti-inflammatory effect of SS was significant only on the 6th day, while the anti-inflammatory effect of SANT MS14 (100 mg/kg) was also significant only on the 6th day. SUSP MS14 (150 mg/kg) significantly reduced edema from second to 6th day. Intra-peritoneal injection of SUSP MS14 with 300 mg/kg was toxic, so excluded from the study. This research indicates that the MS14 possesses an anti-inflammatory effect after intra-peritoneal administration. Comparative anti-inflammatory effects of MS14 with Glucocorticoids in this study, may justify a possible mechanism for its action in multiple sclerosis, if further studies will provid strong statistically confirmatory effects in animals and safety human trials.
format	article
author	Mohsen Naseri Hossein Rezaeizadeh Mahdi Mirghazanfari Taiebeh Taheripanah Zahra Bararpoor Neda Ashayeri Majid Asghari Abbas Talebi Mazrae Shahi Fatemeh Emadi Parvaneh Mohseni Moghaddam Abbas Hashemi Nejad Farzaneh Ghaffari
author_facet	Mohsen Naseri Hossein Rezaeizadeh Mahdi Mirghazanfari Taiebeh Taheripanah Zahra Bararpoor Neda Ashayeri Majid Asghari Abbas Talebi Mazrae Shahi Fatemeh Emadi Parvaneh Mohseni Moghaddam Abbas Hashemi Nejad Farzaneh Ghaffari
author_sort	Mohsen Naseri
title	Anti-inflammatory activity of a natural herbal-marine drug (MS14 - SANT and SUSP) compared to sodium salicylate or methylprednisolone in a rat model for multiple sclerosis
title_short	Anti-inflammatory activity of a natural herbal-marine drug (MS14 - SANT and SUSP) compared to sodium salicylate or methylprednisolone in a rat model for multiple sclerosis
title_full	Anti-inflammatory activity of a natural herbal-marine drug (MS14 - SANT and SUSP) compared to sodium salicylate or methylprednisolone in a rat model for multiple sclerosis
title_fullStr	Anti-inflammatory activity of a natural herbal-marine drug (MS14 - SANT and SUSP) compared to sodium salicylate or methylprednisolone in a rat model for multiple sclerosis
title_full_unstemmed	Anti-inflammatory activity of a natural herbal-marine drug (MS14 - SANT and SUSP) compared to sodium salicylate or methylprednisolone in a rat model for multiple sclerosis
title_sort	anti-inflammatory activity of a natural herbal-marine drug (ms14 - sant and susp) compared to sodium salicylate or methylprednisolone in a rat model for multiple sclerosis
publisher	PAGEPress Publications
publishDate	2021
url	https://doaj.org/article/1d14d961cf1c4f6b8e0151e219301589
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Anti-inflammatory activity of a natural herbal-marine drug (MS14 - SANT and SUSP) compared to sodium salicylate or methylprednisolone in a rat model for multiple sclerosis

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