The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans

lncRNAs are transcriptional regulators, but little is known of them functioning as negative feedback regulators of inflammation in humans. Here, the authors show that the human lncRNA LUCAT1 sequesters STAT1 to limit JAK/STAT signaling and the inflammatory response to viral infection or TLR stimulat...

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Autores principales:	Shiuli Agarwal, Tim Vierbuchen, Sreya Ghosh, Jennie Chan, Zhaozhao Jiang, Richard K. Kandasamy, Emiliano Ricci, Katherine A. Fitzgerald
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d15ab27155343e5bc98b57512bbe82b
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spelling	oai:doaj.org-article:1d15ab27155343e5bc98b57512bbe82b2021-12-02T14:16:32ZThe long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans10.1038/s41467-020-20165-52041-1723https://doaj.org/article/1d15ab27155343e5bc98b57512bbe82b2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20165-5https://doaj.org/toc/2041-1723lncRNAs are transcriptional regulators, but little is known of them functioning as negative feedback regulators of inflammation in humans. Here, the authors show that the human lncRNA LUCAT1 sequesters STAT1 to limit JAK/STAT signaling and the inflammatory response to viral infection or TLR stimulation in myeloid cells.Shiuli AgarwalTim VierbuchenSreya GhoshJennie ChanZhaozhao JiangRichard K. KandasamyEmiliano RicciKatherine A. FitzgeraldNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shiuli Agarwal Tim Vierbuchen Sreya Ghosh Jennie Chan Zhaozhao Jiang Richard K. Kandasamy Emiliano Ricci Katherine A. Fitzgerald The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans
description	lncRNAs are transcriptional regulators, but little is known of them functioning as negative feedback regulators of inflammation in humans. Here, the authors show that the human lncRNA LUCAT1 sequesters STAT1 to limit JAK/STAT signaling and the inflammatory response to viral infection or TLR stimulation in myeloid cells.
format	article
author	Shiuli Agarwal Tim Vierbuchen Sreya Ghosh Jennie Chan Zhaozhao Jiang Richard K. Kandasamy Emiliano Ricci Katherine A. Fitzgerald
author_facet	Shiuli Agarwal Tim Vierbuchen Sreya Ghosh Jennie Chan Zhaozhao Jiang Richard K. Kandasamy Emiliano Ricci Katherine A. Fitzgerald
author_sort	Shiuli Agarwal
title	The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans
title_short	The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans
title_full	The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans
title_fullStr	The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans
title_full_unstemmed	The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans
title_sort	long non-coding rna lucat1 is a negative feedback regulator of interferon responses in humans
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1d15ab27155343e5bc98b57512bbe82b
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The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans

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