Serum lipid profile among sporadic and familial forms of Parkinson’s disease

Abstract Brain cholesterol metabolism has been described as altered in Parkinson’s disease (PD) patients. Serum lipid levels have been widely studied in PD with controversial results among different populations and age groups. The present study is aimed at determining if the serum lipid profile coul...

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Autores principales:	Daniel Macías-García, María Teresa Periñán, Laura Muñoz-Delgado, María Valle Jimenez-Jaraba, Miguel Ángel Labrador-Espinosa, Silvia Jesús, Dolores Buiza-Rueda, Carlota Méndez-Del Barrio, Astrid Adarmes-Gómez, Pilar Gómez-Garre, Pablo Mir
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/1d1b643cb501482fbc05791f44875282
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spelling	oai:doaj.org-article:1d1b643cb501482fbc05791f448752822021-12-02T16:08:09ZSerum lipid profile among sporadic and familial forms of Parkinson’s disease10.1038/s41531-021-00206-62373-8057https://doaj.org/article/1d1b643cb501482fbc05791f448752822021-07-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00206-6https://doaj.org/toc/2373-8057Abstract Brain cholesterol metabolism has been described as altered in Parkinson’s disease (PD) patients. Serum lipid levels have been widely studied in PD with controversial results among different populations and age groups. The present study is aimed at determining if the serum lipid profile could be influenced by the genetic background of PD patients. We included 403 PD patients (342 sporadic PD patients, 30 GBA-associated PD patients, and 31 LRRK2-associated PD patients) and 654 healthy controls (HCs). Total cholesterol, HDL, LDL, and triglycerides were measured in peripheral blood. Analysis of covariance adjusting for sex and age (ANCOVA) and post hoc tests were applied to determine the differences within lipid profiles among the groups. Multivariate ANCOVA revealed significant differences among the groups within cholesterol and LDL levels. GBA-associated PD patients had significantly lower levels of total cholesterol and LDL compared to LRRK2-associated PD patients and HCs. The different serum cholesterol levels in GBA -associated PD might be related to diverse pathogenic mechanisms. Our results support the hypothesis of lipid metabolism disruption as one of the main PD pathogenic mechanisms in patients with GBA-associated PD. Further studies would be necessary to explore their clinical implications.Daniel Macías-GarcíaMaría Teresa PeriñánLaura Muñoz-DelgadoMaría Valle Jimenez-JarabaMiguel Ángel Labrador-EspinosaSilvia JesúsDolores Buiza-RuedaCarlota Méndez-Del BarrioAstrid Adarmes-GómezPilar Gómez-GarrePablo MirNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Daniel Macías-García María Teresa Periñán Laura Muñoz-Delgado María Valle Jimenez-Jaraba Miguel Ángel Labrador-Espinosa Silvia Jesús Dolores Buiza-Rueda Carlota Méndez-Del Barrio Astrid Adarmes-Gómez Pilar Gómez-Garre Pablo Mir Serum lipid profile among sporadic and familial forms of Parkinson’s disease
description	Abstract Brain cholesterol metabolism has been described as altered in Parkinson’s disease (PD) patients. Serum lipid levels have been widely studied in PD with controversial results among different populations and age groups. The present study is aimed at determining if the serum lipid profile could be influenced by the genetic background of PD patients. We included 403 PD patients (342 sporadic PD patients, 30 GBA-associated PD patients, and 31 LRRK2-associated PD patients) and 654 healthy controls (HCs). Total cholesterol, HDL, LDL, and triglycerides were measured in peripheral blood. Analysis of covariance adjusting for sex and age (ANCOVA) and post hoc tests were applied to determine the differences within lipid profiles among the groups. Multivariate ANCOVA revealed significant differences among the groups within cholesterol and LDL levels. GBA-associated PD patients had significantly lower levels of total cholesterol and LDL compared to LRRK2-associated PD patients and HCs. The different serum cholesterol levels in GBA -associated PD might be related to diverse pathogenic mechanisms. Our results support the hypothesis of lipid metabolism disruption as one of the main PD pathogenic mechanisms in patients with GBA-associated PD. Further studies would be necessary to explore their clinical implications.
format	article
author	Daniel Macías-García María Teresa Periñán Laura Muñoz-Delgado María Valle Jimenez-Jaraba Miguel Ángel Labrador-Espinosa Silvia Jesús Dolores Buiza-Rueda Carlota Méndez-Del Barrio Astrid Adarmes-Gómez Pilar Gómez-Garre Pablo Mir
author_facet	Daniel Macías-García María Teresa Periñán Laura Muñoz-Delgado María Valle Jimenez-Jaraba Miguel Ángel Labrador-Espinosa Silvia Jesús Dolores Buiza-Rueda Carlota Méndez-Del Barrio Astrid Adarmes-Gómez Pilar Gómez-Garre Pablo Mir
author_sort	Daniel Macías-García
title	Serum lipid profile among sporadic and familial forms of Parkinson’s disease
title_short	Serum lipid profile among sporadic and familial forms of Parkinson’s disease
title_full	Serum lipid profile among sporadic and familial forms of Parkinson’s disease
title_fullStr	Serum lipid profile among sporadic and familial forms of Parkinson’s disease
title_full_unstemmed	Serum lipid profile among sporadic and familial forms of Parkinson’s disease
title_sort	serum lipid profile among sporadic and familial forms of parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1d1b643cb501482fbc05791f44875282
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Serum lipid profile among sporadic and familial forms of Parkinson’s disease

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