Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9

DNA degradation products are frequently found in the endosome, but how they regulate the activation of Toll-like receptors is not known. Here the authors show that single-stranded DNA as short as two nucleotides can enhance the ability of longer DNA oligonucleotides to activate Toll-like receptors.

Guardado en:

Detalles Bibliográficos
Autores principales:	Jelka Pohar, Duško Lainšček, Karolina Ivičak-Kocjan, Miša-Mojca Cajnko, Roman Jerala, Mojca Benčina
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d1c1bb6f0ba4562a591522915e4394a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1d1c1bb6f0ba4562a591522915e4394a
record_format	dspace
spelling	oai:doaj.org-article:1d1c1bb6f0ba4562a591522915e4394a2021-12-02T17:06:05ZShort single-stranded DNA degradation products augment the activation of Toll-like receptor 910.1038/ncomms153632041-1723https://doaj.org/article/1d1c1bb6f0ba4562a591522915e4394a2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15363https://doaj.org/toc/2041-1723DNA degradation products are frequently found in the endosome, but how they regulate the activation of Toll-like receptors is not known. Here the authors show that single-stranded DNA as short as two nucleotides can enhance the ability of longer DNA oligonucleotides to activate Toll-like receptors.Jelka PoharDuško LainščekKarolina Ivičak-KocjanMiša-Mojca CajnkoRoman JeralaMojca BenčinaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jelka Pohar Duško Lainšček Karolina Ivičak-Kocjan Miša-Mojca Cajnko Roman Jerala Mojca Benčina Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9
description	DNA degradation products are frequently found in the endosome, but how they regulate the activation of Toll-like receptors is not known. Here the authors show that single-stranded DNA as short as two nucleotides can enhance the ability of longer DNA oligonucleotides to activate Toll-like receptors.
format	article
author	Jelka Pohar Duško Lainšček Karolina Ivičak-Kocjan Miša-Mojca Cajnko Roman Jerala Mojca Benčina
author_facet	Jelka Pohar Duško Lainšček Karolina Ivičak-Kocjan Miša-Mojca Cajnko Roman Jerala Mojca Benčina
author_sort	Jelka Pohar
title	Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9
title_short	Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9
title_full	Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9
title_fullStr	Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9
title_full_unstemmed	Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9
title_sort	short single-stranded dna degradation products augment the activation of toll-like receptor 9
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1d1c1bb6f0ba4562a591522915e4394a
work_keys_str_mv	AT jelkapohar shortsinglestrandeddnadegradationproductsaugmenttheactivationoftolllikereceptor9 AT duskolainscek shortsinglestrandeddnadegradationproductsaugmenttheactivationoftolllikereceptor9 AT karolinaivicakkocjan shortsinglestrandeddnadegradationproductsaugmenttheactivationoftolllikereceptor9 AT misamojcacajnko shortsinglestrandeddnadegradationproductsaugmenttheactivationoftolllikereceptor9 AT romanjerala shortsinglestrandeddnadegradationproductsaugmenttheactivationoftolllikereceptor9 AT mojcabencina shortsinglestrandeddnadegradationproductsaugmenttheactivationoftolllikereceptor9
_version_	1718381718494248960

Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9

Ejemplares similares