Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma

Allergic asthma symptoms may be controlled, but currently no effective therapy exist to address the underlying pathology. Here the authors show, using mouse model of adoptive cell transfer, that CD4-CD8- T cells can suppress the function of dendritic cells and T follicular helper cells via Lag3 to p...

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Autores principales:	Dan Tian, Lu Yang, Song Wang, Yanbing Zhu, Wen Shi, Chunpan Zhang, Hua Jin, Yue Tian, Hufeng Xu, Guangyong Sun, Kai Liu, Zhongtao Zhang, Dong Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d233400ebcc4f46a2ab48029ccc97f9
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spelling	oai:doaj.org-article:1d233400ebcc4f46a2ab48029ccc97f92021-12-02T16:57:12ZDouble negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma10.1038/s41467-019-12243-02041-1723https://doaj.org/article/1d233400ebcc4f46a2ab48029ccc97f92019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12243-0https://doaj.org/toc/2041-1723Allergic asthma symptoms may be controlled, but currently no effective therapy exist to address the underlying pathology. Here the authors show, using mouse model of adoptive cell transfer, that CD4-CD8- T cells can suppress the function of dendritic cells and T follicular helper cells via Lag3 to provide allergen-specific protection from asthma.Dan TianLu YangSong WangYanbing ZhuWen ShiChunpan ZhangHua JinYue TianHufeng XuGuangyong SunKai LiuZhongtao ZhangDong ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dan Tian Lu Yang Song Wang Yanbing Zhu Wen Shi Chunpan Zhang Hua Jin Yue Tian Hufeng Xu Guangyong Sun Kai Liu Zhongtao Zhang Dong Zhang Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma
description	Allergic asthma symptoms may be controlled, but currently no effective therapy exist to address the underlying pathology. Here the authors show, using mouse model of adoptive cell transfer, that CD4-CD8- T cells can suppress the function of dendritic cells and T follicular helper cells via Lag3 to provide allergen-specific protection from asthma.
format	article
author	Dan Tian Lu Yang Song Wang Yanbing Zhu Wen Shi Chunpan Zhang Hua Jin Yue Tian Hufeng Xu Guangyong Sun Kai Liu Zhongtao Zhang Dong Zhang
author_facet	Dan Tian Lu Yang Song Wang Yanbing Zhu Wen Shi Chunpan Zhang Hua Jin Yue Tian Hufeng Xu Guangyong Sun Kai Liu Zhongtao Zhang Dong Zhang
author_sort	Dan Tian
title	Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma
title_short	Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma
title_full	Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma
title_fullStr	Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma
title_full_unstemmed	Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma
title_sort	double negative t cells mediate lag3-dependent antigen-specific protection in allergic asthma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1d233400ebcc4f46a2ab48029ccc97f9
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Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma

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