A tRNA half modulates translation as stress response in Trypanosoma brucei

Trypanosoma brucei mainly relies on translational regulation to adjust gene expression, but details are unclear. Here the authors show that, under stress conditions, tRNAThr half level increases, associates with ribosomes and polysomes, and stimulates protein synthesis by facilitating mRNA loading.

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Autores principales:	Roger Fricker, Rebecca Brogli, Hannes Luidalepp, Leander Wyss, Michel Fasnacht, Oliver Joss, Marek Zywicki, Mark Helm, André Schneider, Marina Cristodero, Norbert Polacek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d23c87897e1460f9d583fc47617f772
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spelling	oai:doaj.org-article:1d23c87897e1460f9d583fc47617f7722021-12-02T16:58:24ZA tRNA half modulates translation as stress response in Trypanosoma brucei10.1038/s41467-018-07949-62041-1723https://doaj.org/article/1d23c87897e1460f9d583fc47617f7722019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07949-6https://doaj.org/toc/2041-1723Trypanosoma brucei mainly relies on translational regulation to adjust gene expression, but details are unclear. Here the authors show that, under stress conditions, tRNAThr half level increases, associates with ribosomes and polysomes, and stimulates protein synthesis by facilitating mRNA loading.Roger FrickerRebecca BrogliHannes LuidaleppLeander WyssMichel FasnachtOliver JossMarek ZywickiMark HelmAndré SchneiderMarina CristoderoNorbert PolacekNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Roger Fricker Rebecca Brogli Hannes Luidalepp Leander Wyss Michel Fasnacht Oliver Joss Marek Zywicki Mark Helm André Schneider Marina Cristodero Norbert Polacek A tRNA half modulates translation as stress response in Trypanosoma brucei
description	Trypanosoma brucei mainly relies on translational regulation to adjust gene expression, but details are unclear. Here the authors show that, under stress conditions, tRNAThr half level increases, associates with ribosomes and polysomes, and stimulates protein synthesis by facilitating mRNA loading.
format	article
author	Roger Fricker Rebecca Brogli Hannes Luidalepp Leander Wyss Michel Fasnacht Oliver Joss Marek Zywicki Mark Helm André Schneider Marina Cristodero Norbert Polacek
author_facet	Roger Fricker Rebecca Brogli Hannes Luidalepp Leander Wyss Michel Fasnacht Oliver Joss Marek Zywicki Mark Helm André Schneider Marina Cristodero Norbert Polacek
author_sort	Roger Fricker
title	A tRNA half modulates translation as stress response in Trypanosoma brucei
title_short	A tRNA half modulates translation as stress response in Trypanosoma brucei
title_full	A tRNA half modulates translation as stress response in Trypanosoma brucei
title_fullStr	A tRNA half modulates translation as stress response in Trypanosoma brucei
title_full_unstemmed	A tRNA half modulates translation as stress response in Trypanosoma brucei
title_sort	trna half modulates translation as stress response in trypanosoma brucei
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1d23c87897e1460f9d583fc47617f772
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A tRNA half modulates translation as stress response in Trypanosoma brucei

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