Role of Vaginal Fluid Aspartate Aminotransferase and Alanine Aminotransferase in the Diagnosis of Pre-Labor Rupture of Membranes

Background: Pre-labor rupture of membrane is a common obstetric complication. Rapid and good diagnosis is needed to prevent bad obstetric complication and unneeded hospitalization. Aim of work: The aim of this study was to evaluate the reliability of aspartate aminotransferase [AST] and alanine amin...

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Autores principales:	Aya Elnemr, Rashed Rashed, Alaa Alarshal
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	rupture of membranes alanine aspartate aminotransferase vaginal washing fluid amniotic fluid Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1d27791a2f5047c18da37b250f11c637
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spelling	oai:doaj.org-article:1d27791a2f5047c18da37b250f11c6372021-12-02T16:35:04ZRole of Vaginal Fluid Aspartate Aminotransferase and Alanine Aminotransferase in the Diagnosis of Pre-Labor Rupture of Membranes2636-41742682-378010.21608/ijma.2021.76404.1316https://doaj.org/article/1d27791a2f5047c18da37b250f11c6372021-07-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_178216_06ec4e105e175819b0290ea7185f59f7.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Pre-labor rupture of membrane is a common obstetric complication. Rapid and good diagnosis is needed to prevent bad obstetric complication and unneeded hospitalization. Aim of work: The aim of this study was to evaluate the reliability of aspartate aminotransferase [AST] and alanine aminotransferase [ALT] enzymes measurement in vaginal washing fluid for the diagnosis of pre-labour rupture of membranes. Patient and method: This case-control study was carried out in two departments of Obstetrics and Gynecology [Al-Azhar University Hospital, New Damietta and Senbellawein General Hospital], between March 2019 and December 2020. It included 90 pregnant women at gestational age 30-40 weeks. They were divided into two equal groups. Group І [case group, PROM group]: included women with diagnosis of rupture of membranes confirmed by visualization of amniotic fluid passing from the cervical canal, and Group ІІ [control group] included women without any complaint or complication. All were clinically evaluated and the vaginal fluid was aspirated for laboratory analysis. Results: Results revealed significant differences between the studied groups. The mean AST level in the PROM group was 18.84±5.74 and 3.33±1.29 in the control group [p <0.001]. The optimal cutoff concentration for AST levels in vaginal secretions is >8 IU/L. The mean ALT levels were 5.09±2.1 in the PROM and 1.13±0.94 in the control group, with significant difference between groups [p <0.001]. The cutoff value of >2.5 IU/L is optimal. Conclusion: Vaginal fluid Aspartate aminotransferase [AST] and Alanine aminotransferase [ALT] have high sensitivity and high negative predictive value. So, they are considered a good screening tests for detection of PROM. Also measuring vaginal fluid AST and ALT levels are cheaper, faster, available and reliable method for detection of pre-labor rupture of membranes.Aya ElnemrRashed RashedAlaa AlarshalAl-Azhar University, Faculty of Medicine (Damietta)articlerupture of membranesalanineaspartate aminotransferasevaginal washing fluidamniotic fluidMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 3, Pp 1636-1641 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	rupture of membranes alanine aspartate aminotransferase vaginal washing fluid amniotic fluid Medicine (General) R5-920
spellingShingle	rupture of membranes alanine aspartate aminotransferase vaginal washing fluid amniotic fluid Medicine (General) R5-920 Aya Elnemr Rashed Rashed Alaa Alarshal Role of Vaginal Fluid Aspartate Aminotransferase and Alanine Aminotransferase in the Diagnosis of Pre-Labor Rupture of Membranes
description	Background: Pre-labor rupture of membrane is a common obstetric complication. Rapid and good diagnosis is needed to prevent bad obstetric complication and unneeded hospitalization. Aim of work: The aim of this study was to evaluate the reliability of aspartate aminotransferase [AST] and alanine aminotransferase [ALT] enzymes measurement in vaginal washing fluid for the diagnosis of pre-labour rupture of membranes. Patient and method: This case-control study was carried out in two departments of Obstetrics and Gynecology [Al-Azhar University Hospital, New Damietta and Senbellawein General Hospital], between March 2019 and December 2020. It included 90 pregnant women at gestational age 30-40 weeks. They were divided into two equal groups. Group І [case group, PROM group]: included women with diagnosis of rupture of membranes confirmed by visualization of amniotic fluid passing from the cervical canal, and Group ІІ [control group] included women without any complaint or complication. All were clinically evaluated and the vaginal fluid was aspirated for laboratory analysis. Results: Results revealed significant differences between the studied groups. The mean AST level in the PROM group was 18.84±5.74 and 3.33±1.29 in the control group [p <0.001]. The optimal cutoff concentration for AST levels in vaginal secretions is >8 IU/L. The mean ALT levels were 5.09±2.1 in the PROM and 1.13±0.94 in the control group, with significant difference between groups [p <0.001]. The cutoff value of >2.5 IU/L is optimal. Conclusion: Vaginal fluid Aspartate aminotransferase [AST] and Alanine aminotransferase [ALT] have high sensitivity and high negative predictive value. So, they are considered a good screening tests for detection of PROM. Also measuring vaginal fluid AST and ALT levels are cheaper, faster, available and reliable method for detection of pre-labor rupture of membranes.
format	article
author	Aya Elnemr Rashed Rashed Alaa Alarshal
author_facet	Aya Elnemr Rashed Rashed Alaa Alarshal
author_sort	Aya Elnemr
title	Role of Vaginal Fluid Aspartate Aminotransferase and Alanine Aminotransferase in the Diagnosis of Pre-Labor Rupture of Membranes
title_short	Role of Vaginal Fluid Aspartate Aminotransferase and Alanine Aminotransferase in the Diagnosis of Pre-Labor Rupture of Membranes
title_full	Role of Vaginal Fluid Aspartate Aminotransferase and Alanine Aminotransferase in the Diagnosis of Pre-Labor Rupture of Membranes
title_fullStr	Role of Vaginal Fluid Aspartate Aminotransferase and Alanine Aminotransferase in the Diagnosis of Pre-Labor Rupture of Membranes
title_full_unstemmed	Role of Vaginal Fluid Aspartate Aminotransferase and Alanine Aminotransferase in the Diagnosis of Pre-Labor Rupture of Membranes
title_sort	role of vaginal fluid aspartate aminotransferase and alanine aminotransferase in the diagnosis of pre-labor rupture of membranes
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/1d27791a2f5047c18da37b250f11c637
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Role of Vaginal Fluid Aspartate Aminotransferase and Alanine Aminotransferase in the Diagnosis of Pre-Labor Rupture of Membranes

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