Peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study

Abstract Brain activity associated with pain perception has been revealed by numerous PET and fMRI studies over the past few decades. These findings helped to establish the concept of the pain matrix, which is the distributed brain networks that demonstrate pain-specific cortical activities. We prev...

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Autores principales:	Toshio Tsuji, Fumiya Arikuni, Takafumi Sasaoka, Shin Suyama, Takashi Akiyoshi, Zu Soh, Harutoyo Hirano, Ryuji Nakamura, Noboru Saeki, Masashi Kawamoto, Masao Yoshizumi, Atsuo Yoshino, Shigeto Yamawaki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1d29bfd16ac94b3cb7bd6a34e85511c6
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spelling	oai:doaj.org-article:1d29bfd16ac94b3cb7bd6a34e85511c62021-12-02T15:53:59ZPeripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study10.1038/s41598-021-83833-62045-2322https://doaj.org/article/1d29bfd16ac94b3cb7bd6a34e85511c62021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83833-6https://doaj.org/toc/2045-2322Abstract Brain activity associated with pain perception has been revealed by numerous PET and fMRI studies over the past few decades. These findings helped to establish the concept of the pain matrix, which is the distributed brain networks that demonstrate pain-specific cortical activities. We previously found that peripheral arterial stiffness $${\beta }_{\text{art}}$$ β art responds to pain intensity, which is estimated from electrocardiography, continuous sphygmomanometer, and photo-plethysmography. However, it remains unclear whether and to what extent $${\beta }_{\text{art}}$$ β art aligns with pain matrix brain activity. In this fMRI study, 22 participants received different intensities of pain stimuli. We identified brain regions in which the blood oxygen level-dependent signal covaried with $${\beta }_{\text{art}}$$ β art using parametric modulation analysis. Among the identified brain regions, the lateral and medial prefrontal cortex and ventral and dorsal anterior cingulate cortex were consistent with the pain matrix. We found moderate correlations between the average activities in these regions and $${\beta }_{\text{art}}$$ β art (r = 0.47, p < 0.001). $${\beta }_{\text{art}}$$ β art was also significantly correlated with self-reported pain intensity (r = 0.44, p < 0.001) and applied pain intensity (r = 0.43, p < 0.001). Our results indicate that $${\beta }_{\text{art}}$$ β art is positively correlated with pain-related brain activity and subjective pain intensity. This study may thus represent a basis for adopting peripheral arterial stiffness as an objective pain evaluation metric.Toshio TsujiFumiya ArikuniTakafumi SasaokaShin SuyamaTakashi AkiyoshiZu SohHarutoyo HiranoRyuji NakamuraNoboru SaekiMasashi KawamotoMasao YoshizumiAtsuo YoshinoShigeto YamawakiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Toshio Tsuji Fumiya Arikuni Takafumi Sasaoka Shin Suyama Takashi Akiyoshi Zu Soh Harutoyo Hirano Ryuji Nakamura Noboru Saeki Masashi Kawamoto Masao Yoshizumi Atsuo Yoshino Shigeto Yamawaki Peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study
description	Abstract Brain activity associated with pain perception has been revealed by numerous PET and fMRI studies over the past few decades. These findings helped to establish the concept of the pain matrix, which is the distributed brain networks that demonstrate pain-specific cortical activities. We previously found that peripheral arterial stiffness $${\beta }_{\text{art}}$$ β art responds to pain intensity, which is estimated from electrocardiography, continuous sphygmomanometer, and photo-plethysmography. However, it remains unclear whether and to what extent $${\beta }_{\text{art}}$$ β art aligns with pain matrix brain activity. In this fMRI study, 22 participants received different intensities of pain stimuli. We identified brain regions in which the blood oxygen level-dependent signal covaried with $${\beta }_{\text{art}}$$ β art using parametric modulation analysis. Among the identified brain regions, the lateral and medial prefrontal cortex and ventral and dorsal anterior cingulate cortex were consistent with the pain matrix. We found moderate correlations between the average activities in these regions and $${\beta }_{\text{art}}$$ β art (r = 0.47, p < 0.001). $${\beta }_{\text{art}}$$ β art was also significantly correlated with self-reported pain intensity (r = 0.44, p < 0.001) and applied pain intensity (r = 0.43, p < 0.001). Our results indicate that $${\beta }_{\text{art}}$$ β art is positively correlated with pain-related brain activity and subjective pain intensity. This study may thus represent a basis for adopting peripheral arterial stiffness as an objective pain evaluation metric.
format	article
author	Toshio Tsuji Fumiya Arikuni Takafumi Sasaoka Shin Suyama Takashi Akiyoshi Zu Soh Harutoyo Hirano Ryuji Nakamura Noboru Saeki Masashi Kawamoto Masao Yoshizumi Atsuo Yoshino Shigeto Yamawaki
author_facet	Toshio Tsuji Fumiya Arikuni Takafumi Sasaoka Shin Suyama Takashi Akiyoshi Zu Soh Harutoyo Hirano Ryuji Nakamura Noboru Saeki Masashi Kawamoto Masao Yoshizumi Atsuo Yoshino Shigeto Yamawaki
author_sort	Toshio Tsuji
title	Peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study
title_short	Peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study
title_full	Peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study
title_fullStr	Peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study
title_full_unstemmed	Peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study
title_sort	peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fmri study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1d29bfd16ac94b3cb7bd6a34e85511c6
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Peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study

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