Visual outcomes of age-related macular degeneration patients undergoing intravitreal ranibizumab monotherapy in an urban population

Khadijah Basheer, Evelyn Mensah, Tina Khanam, Neda Minakaran Ophthalmology Department, Central Middlesex Hospital, London, UK Aim: To compare the visual outcomes of an urban population with age-related macular degeneration (AMD) undergoing ranibizumab monotherapy to the results from major clinical...

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Autores principales:	Basheer K, Mensah E, Khanam T, Minakaran N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/1d29dcaede704a64b05da8279d4ce59c
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spelling	oai:doaj.org-article:1d29dcaede704a64b05da8279d4ce59c2021-12-02T01:06:09ZVisual outcomes of age-related macular degeneration patients undergoing intravitreal ranibizumab monotherapy in an urban population1177-5483https://doaj.org/article/1d29dcaede704a64b05da8279d4ce59c2015-05-01T00:00:00Zhttp://www.dovepress.com/visual-outcomes-of-age-related-macular-degeneration-patients-undergoin-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Khadijah Basheer, Evelyn Mensah, Tina Khanam, Neda Minakaran Ophthalmology Department, Central Middlesex Hospital, London, UK Aim: To compare the visual outcomes of an urban population with age-related macular degeneration (AMD) undergoing ranibizumab monotherapy to the results from major clinical trials.Procedures: Prospective data was collected from 164 wet AMD patients receiving intravitreal ranibizumab. Visual acuities were obtained with the Early Treatment Diabetic Retinopathy Study chart. All patients underwent a loading phase of three monthly treatments of ranibizumab. Patients were monitored monthly using a retreatment criterion. Treatment was further individualized by sequentially lengthening follow-up intervals when stable.Results: At 12 and 24 months, respectively, the percentage of eyes that maintained vision was 91% and 88.6%. We found that 20.3% of eyes had improved vision at 12 months and 20% at 24 months. At 12 months, 8.3% of eyes’ vision worsened and 12% worsened at 24 months.Conclusion: Individualized ranibizumab monotherapy is effective in preserving vision in wet AMD and follows the same trends as the pivotal trials. Keywords: visual acuity, comparison of age-related macular degeneration treatment trials, choroidal neovascular membraneBasheer KMensah EKhanam TMinakaran NDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 959-965 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Basheer K Mensah E Khanam T Minakaran N Visual outcomes of age-related macular degeneration patients undergoing intravitreal ranibizumab monotherapy in an urban population
description	Khadijah Basheer, Evelyn Mensah, Tina Khanam, Neda Minakaran Ophthalmology Department, Central Middlesex Hospital, London, UK Aim: To compare the visual outcomes of an urban population with age-related macular degeneration (AMD) undergoing ranibizumab monotherapy to the results from major clinical trials.Procedures: Prospective data was collected from 164 wet AMD patients receiving intravitreal ranibizumab. Visual acuities were obtained with the Early Treatment Diabetic Retinopathy Study chart. All patients underwent a loading phase of three monthly treatments of ranibizumab. Patients were monitored monthly using a retreatment criterion. Treatment was further individualized by sequentially lengthening follow-up intervals when stable.Results: At 12 and 24 months, respectively, the percentage of eyes that maintained vision was 91% and 88.6%. We found that 20.3% of eyes had improved vision at 12 months and 20% at 24 months. At 12 months, 8.3% of eyes’ vision worsened and 12% worsened at 24 months.Conclusion: Individualized ranibizumab monotherapy is effective in preserving vision in wet AMD and follows the same trends as the pivotal trials. Keywords: visual acuity, comparison of age-related macular degeneration treatment trials, choroidal neovascular membrane
format	article
author	Basheer K Mensah E Khanam T Minakaran N
author_facet	Basheer K Mensah E Khanam T Minakaran N
author_sort	Basheer K
title	Visual outcomes of age-related macular degeneration patients undergoing intravitreal ranibizumab monotherapy in an urban population
title_short	Visual outcomes of age-related macular degeneration patients undergoing intravitreal ranibizumab monotherapy in an urban population
title_full	Visual outcomes of age-related macular degeneration patients undergoing intravitreal ranibizumab monotherapy in an urban population
title_fullStr	Visual outcomes of age-related macular degeneration patients undergoing intravitreal ranibizumab monotherapy in an urban population
title_full_unstemmed	Visual outcomes of age-related macular degeneration patients undergoing intravitreal ranibizumab monotherapy in an urban population
title_sort	visual outcomes of age-related macular degeneration patients undergoing intravitreal ranibizumab monotherapy in an urban population
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/1d29dcaede704a64b05da8279d4ce59c
work_keys_str_mv	AT basheerk visualoutcomesofagerelatedmaculardegenerationpatientsundergoingintravitrealranibizumabmonotherapyinanurbanpopulation AT mensahe visualoutcomesofagerelatedmaculardegenerationpatientsundergoingintravitrealranibizumabmonotherapyinanurbanpopulation AT khanamt visualoutcomesofagerelatedmaculardegenerationpatientsundergoingintravitrealranibizumabmonotherapyinanurbanpopulation AT minakarann visualoutcomesofagerelatedmaculardegenerationpatientsundergoingintravitrealranibizumabmonotherapyinanurbanpopulation
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Visual outcomes of age-related macular degeneration patients undergoing intravitreal ranibizumab monotherapy in an urban population

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