A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A

The Neisseria meningitidis serogroup A capsular polysaccharide (MenA CPS) is a component of commercial vaccines, but is unstable. Here, the authors generate glycomimetic oligomers that demonstrate higher stability than their natural counterparts and induce protective antibodies in mice.

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Autores principales:	Jacopo Enotarpi, Marta Tontini, Cristiana Balocchi, Daan van der Es, Ludovic Auberger, Evita Balducci, Filippo Carboni, Daniela Proietti, Daniele Casini, Dmitri V. Filippov, Hermen S. Overkleeft, Gijsbert A. van der Marel, Cinzia Colombo, Maria Rosaria Romano, Francesco Berti, Paolo Costantino, Jeroen D. C. Codeé, Luigi Lay, Roberto Adamo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d2c58955e994faaa3143dcfc9de2b58
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spelling	oai:doaj.org-article:1d2c58955e994faaa3143dcfc9de2b582021-12-02T17:42:11ZA stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A10.1038/s41467-020-18279-x2041-1723https://doaj.org/article/1d2c58955e994faaa3143dcfc9de2b582020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18279-xhttps://doaj.org/toc/2041-1723The Neisseria meningitidis serogroup A capsular polysaccharide (MenA CPS) is a component of commercial vaccines, but is unstable. Here, the authors generate glycomimetic oligomers that demonstrate higher stability than their natural counterparts and induce protective antibodies in mice.Jacopo EnotarpiMarta TontiniCristiana BalocchiDaan van der EsLudovic AubergerEvita BalducciFilippo CarboniDaniela ProiettiDaniele CasiniDmitri V. FilippovHermen S. OverkleeftGijsbert A. van der MarelCinzia ColomboMaria Rosaria RomanoFrancesco BertiPaolo CostantinoJeroen D. C. CodeéLuigi LayRoberto AdamoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jacopo Enotarpi Marta Tontini Cristiana Balocchi Daan van der Es Ludovic Auberger Evita Balducci Filippo Carboni Daniela Proietti Daniele Casini Dmitri V. Filippov Hermen S. Overkleeft Gijsbert A. van der Marel Cinzia Colombo Maria Rosaria Romano Francesco Berti Paolo Costantino Jeroen D. C. Codeé Luigi Lay Roberto Adamo A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A
description	The Neisseria meningitidis serogroup A capsular polysaccharide (MenA CPS) is a component of commercial vaccines, but is unstable. Here, the authors generate glycomimetic oligomers that demonstrate higher stability than their natural counterparts and induce protective antibodies in mice.
format	article
author	Jacopo Enotarpi Marta Tontini Cristiana Balocchi Daan van der Es Ludovic Auberger Evita Balducci Filippo Carboni Daniela Proietti Daniele Casini Dmitri V. Filippov Hermen S. Overkleeft Gijsbert A. van der Marel Cinzia Colombo Maria Rosaria Romano Francesco Berti Paolo Costantino Jeroen D. C. Codeé Luigi Lay Roberto Adamo
author_facet	Jacopo Enotarpi Marta Tontini Cristiana Balocchi Daan van der Es Ludovic Auberger Evita Balducci Filippo Carboni Daniela Proietti Daniele Casini Dmitri V. Filippov Hermen S. Overkleeft Gijsbert A. van der Marel Cinzia Colombo Maria Rosaria Romano Francesco Berti Paolo Costantino Jeroen D. C. Codeé Luigi Lay Roberto Adamo
author_sort	Jacopo Enotarpi
title	A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A
title_short	A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A
title_full	A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A
title_fullStr	A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A
title_full_unstemmed	A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A
title_sort	stabilized glycomimetic conjugate vaccine inducing protective antibodies against neisseria meningitidis serogroup a
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1d2c58955e994faaa3143dcfc9de2b58
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A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A

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